DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR3 and 18w

DIOPT Version :9

Sequence 1:NP_003256.1 Gene:TLR3 / 7098 HGNCID:11849 Length:904 Species:Homo sapiens
Sequence 2:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster


Alignment Length:1007 Identity:220/1007 - (21%)
Similarity:378/1007 - (37%) Gaps:248/1007 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    51 TNITVLNLTHNQLRRLPAA-NFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQL 114
            :.:..|:::.|:||.||.| ..:|..:|.:|.:..|.||.|.|.....|..|:|||:.:|.|..|
  Fly   210 SELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSL 274

Human   115 SDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKL--GTQVQLENLQELL 177
            ..:.||....|.||||..|.:.::......:.:.|:.||||.|.|:|..:  .|...|..|..|.
  Fly   275 PSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLN 339

Human   178 LSNNKIQALKSEE---------LDIFANS-------------SLKKLELSSNQIKEFSPGCFHAI 220
            ||||.:..:.|:.         ||:..||             :|..|.|:.|::.......|:.:
  Fly   340 LSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGL 404

Human   221 GRLFGLFLNN--VQLGPSLTEKLCLELAN------------------TSIRNLSLSNSQLSTTSN 265
            ..|..|.|||  |.:..|...:.|.:|..                  :.::.|.|..:|:|...|
  Fly   405 YVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKN 469

Human   266 TTFLGL-KWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNL 329
            .||..| :.|.|.::|....|:.|   ..|..||:|....|..|.||.:...:......:..:.|
  Fly   470 NTFRNLNQLTGLRLIDNRIGNITV---GMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRL 531

Human   330 KRSFTKQSISLASLPKIDDFS--FQWLKCLEHLNMEDN-----DIPGIKSNMFTGLINLKYLSLS 387
            .::|            :.|.:  |..|..|..||:.:|     |...|.||:....|:..|:...
  Fly   532 DKNF------------LTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEAL 584

Human   388 NSFTSLRTLTNETFVSLAH------------SPLHILNLTKNKISKIESDAFSWLGHLEVLDL-- 438
            .::..|:.....|.:..:|            :.:.:|.:..|.|.:|:::.|.....|..:||  
  Fly   585 GNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYA 649

Human   439 ------GLNEIGQELTGQEWRGLENIFEIYLSYN--------KYLQLTRNSFALVPSLQRLMLRR 489
                  .||.:.......|    :.:.|.||..|        ::||...|          |..|:
  Fly   650 NVLSKISLNALRVAPVSAE----KPVPEFYLGGNPFECDCSMEWLQRINN----------LTTRQ 700

Human   490 ----VALKNVD-----SSPSPFQPLRNLTILD--------------------------------- 512
                |.|.|::     |..:|.:||.:|:..|                                 
  Fly   701 HPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSC 765

Human   513 ---------------------------------LSNNNIANINDDMLEGLEKLEILDLQHNNLAR 544
                                             |..||:..:....|.|...|..|.|..:||..
  Fly   766 FHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMT 830

Human   545 LWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQ 609
            |...:        |..|.:|.:|:||:|....:....|:.|..|:.:.|..|.|..:..:.|...
  Fly   831 LQNGS--------LAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPL 887

Human   610 VSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSH 674
            |||:.|.|..|.::|:....:..:.:.||   :..|.:.|.|:.:.....::::....:.:....
  Fly   888 VSLEVLRLDNNRLSSLPHLQYRHSLQGLT---LGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDI 949

Human   675 Y---------------LCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIH 724
            |               |.|.|...........:.||.:|.|......::...::|||:.:||:|.
  Fly   950 YCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIV 1014

Human   725 F---EGWRISFYWNVSVHRVLGFKEIDRQTEQFE-----YAAYIIHAYKDKDWVWEHFSS-MEKE 780
            |   |..|:..:.:..| ||.        ..:||     |.|.|:|:.||.::|..:.:: :|..
  Fly  1015 FVFRESVRMWLFAHYGV-RVC--------EPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHG 1070

Human   781 DQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLD 845
            ....:.|:::||.......|: :|...:.|||||.|:|.:||... ..|.:..:|..:::.....
  Fly  1071 RPPFRLCIQQRDLPPQASHLQ-LVEGARASRKIILVLTRNLLATE-WNRIEFRNAFHESLRGLAQ 1133

Human   846 SIILV-----------------FLEEIPDYKL 860
            .::::                 :|:.:|..:|
  Fly  1134 KLVIIEETSVSAEAEDVAELSPYLKSVPSNRL 1165

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
TLR3NP_003256.1 LRRNT 28..50 CDD:396168