DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR3 and Toll-7

DIOPT Version :9

Sequence 1:NP_003256.1 Gene:TLR3 / 7098 HGNCID:11849 Length:904 Species:Homo sapiens
Sequence 2:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster


Alignment Length:1153 Identity:235/1153 - (20%)
Similarity:399/1153 - (34%) Gaps:373/1153 - (32%)


- Green bases have known domain annotations that are detailed below.


Human     4 TLPC--IYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLN----LTHNQ 62
            |:.|  :|.:...||..:.....|.      |.......||.|:|::....:..|.    .|||.
  Fly   112 TIQCSELYLFESTLPVAVFARLQTL------EALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNS 170

Human    63 -------LRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFA 120
                   |...| .:.....|||.||:|.|.:.:|.......:..|:||||..|.:.......||
  Fly   171 EWGPTRTLELFP-DSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFA 234

Human   121 --FC--------TNLTELHLMSNSIQKIKNNPFVKQ-KNLITLDLSHNGLSSTKLGTQVQLENLQ 174
              .|        :.|..|....|.::.|..:..:.: :.|..|:|::|.||.........|.:|:
  Fly   235 DMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLR 299

Human   175 ELLLSNNKIQALKSEELDIFANS-SLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLT 238
            .:.||||.::.|..   .:||.| .|:::.|..|::.|...|.||.:                  
  Fly   300 IVNLSNNHLETLPE---GLFAGSKELREIHLQQNELYELPKGLFHRL------------------ 343

Human   239 EKLCLELANTSIRNLSLSNSQLST--TSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLE 301
            |:|.:         :.||.:||::  ..||||.||  ..|.:|:|::|.|..:...:|..|..|:
  Fly   344 EQLLV---------VDLSGNQLTSNHVDNTTFAGL--IRLIVLNLAHNALTRIDYRTFKELYFLQ 397

Human   302 YFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDND 366
            ...|..|:|.|:..::...|:|:..|||..:         .|..:||..|..|..|..|.:.:|.
  Fly   398 ILNLRNNSIGHIEDNAFLPLYNLHTLNLAEN---------RLHTLDDKLFNGLYVLSKLTLNNNL 453

Human   367 IPGIKSNMFTGLINLKYLSLSNS---------------------FTSLRTLTNETFVSLAHS--- 407
            |..::..:|....:||.|.||::                     ...:||..|::|.:| |.   
  Fly   454 ISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNL-HQLTG 517

Human   408 --------------------PLHILNLTKNKISKIESDAFSWLGHLEVLDL------GLNEIGQE 446
                                .|.:|||.||:|..||..:|.....||.:.|      .:|.:...
  Fly   518 LRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFAT 582

Human   447 LTGQEWRGLENIFEIYLSYN------KYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPS----- 500
            |....|..|.....::..|.      |:|.:..|....:.:..:|. ..:.:|.:|:|.:     
  Fly   583 LVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQ-EEIRVKTLDASHNRITEI 646

Human   501 -PFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARL------------------- 545
             |......:.:|.::||.|.|:..:.......|..:||..|.|::|                   
  Fly   647 GPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEF 711

Human   546 --------------W-------------------------KHANPGGPIYFLKGL---------- 561
                          |                         .||. |..:..|.||          
  Fly   712 YLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHAR-GAAVRPLSGLRPQDFLCRYE 775

Human   562 SHL-----------------------------------------------------HILNLESNG 573
            ||.                                                     .::.|:.|.
  Fly   776 SHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNN 840

Human   574 FDEIPV---------------------------EVFKDLFELKIIDLGLNNLNTLPASVFNNQVS 611
            |   ||                           ..|..|..|:::.|..|.|.||....|....:
  Fly   841 F---PVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSA 902

Human   612 LKSLNLQKNLITSVEKKVFGP-AFRNLTELD-------------------------MRFNPFDCT 650
            |:.|.||.|.:|::|.....| |...|..:|                         :..|.:.|.
  Fly   903 LRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCR 967

Human   651 CESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSS------------------CK 697
            |:.:....:::.:....:.:....| |.......| ...|.|:||                  |.
  Fly   968 CQFLQALTSYVADNALIVQDAQDIY-CMAASSGTG-SAALEDSSSNSGSLEKRELDFNATGAACT 1030

Human   698 D----------SAPFELFFMINTSILLIFIFIVLLIHF---EGWRISFYWNVSVHRVLGFKEIDR 749
            |          ..|.....::..::.|:|:.:|:.:.|   |..||..:.:..| ||.|     .
  Fly  1031 DYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHYGV-RVFG-----P 1089

Human   750 QTEQFE--YAAYIIHAYKDKDWVWEHFSS-MEKEDQSLKFCLEERDF--EAGVFELEAIVNSIKR 809
            :.|:.|  |.|.::|:.||.::|.:|.:: :|.....|:.||:.||.  :|..::|   :.:.:.
  Fly  1090 RCEESEKLYDAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHRDLAHDATHYQL---LEATRV 1151

Human   810 SRKIIFVITHHLLKDPLCK---RFKVHHAVQQAIEQNLDSIILVFLEE 854
            ||:::.::|.:.|:....:   |..||.|::...::      ||.:||
  Fly  1152 SRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQK------LVIIEE 1193

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR3NP_003256.1 LRRNT 28..50 CDD:396168 5/21 (24%)
leucine-rich repeat 33..52 CDD:275380 5/18 (28%)
LRR 1 52..73 6/31 (19%)
leucine-rich repeat 53..76 CDD:275380 6/33 (18%)
PLN00113 72..>542 CDD:215061 129/545 (24%)
LRR 2 76..97 8/20 (40%)
leucine-rich repeat 77..100 CDD:275380 7/22 (32%)
LRR 3 100..121 8/22 (36%)
leucine-rich repeat 101..124 CDD:275380 9/32 (28%)
LRR 4 124..145 4/20 (20%)
leucine-rich repeat 125..148 CDD:275380 4/23 (17%)
LRR 5 148..168 6/19 (32%)
leucine-rich repeat 149..198 CDD:275380 16/49 (33%)
LRR 6 172..193 6/20 (30%)
LRR 7 198..219 6/20 (30%)
leucine-rich repeat 199..249 CDD:275380 9/49 (18%)
LRR 8 222..244 2/21 (10%)
LRR 9 249..270 8/22 (36%)
leucine-rich repeat 250..275 CDD:275380 10/26 (38%)
LRR 10 275..296 6/20 (30%)
leucine-rich repeat 276..299 CDD:275380 7/22 (32%)
LRR 11 299..320 5/20 (25%)
leucine-rich repeat 300..321 CDD:275380 5/20 (25%)
LRR 12 323..344 4/20 (20%)
LRR 13 356..377 5/20 (25%)
leucine-rich repeat 357..380 CDD:275380 5/22 (23%)
LRR 14 380..400 8/40 (20%)
leucine-rich repeat 381..406 CDD:275380 10/45 (22%)
LRR 15 408..429 10/20 (50%)
leucine-rich repeat 409..432 CDD:275380 10/22 (45%)
LRR 16 432..454 6/27 (22%)
leucine-rich repeat 433..457 CDD:275380 7/29 (24%)
leucine-rich repeat 458..481 CDD:275380 4/28 (14%)
LRR 17 465..486 4/26 (15%)
leucine-rich repeat 482..507 CDD:275380 5/30 (17%)
LRR 18 507..528 5/20 (25%)
leucine-rich repeat 508..531 CDD:275380 5/22 (23%)
LRR 19 531..552 9/78 (12%)
leucine-rich repeat 532..563 CDD:275380 13/98 (13%)
LRR_8 562..622 CDD:404697 21/139 (15%)
LRR 20 563..584 7/100 (7%)
leucine-rich repeat 564..585 CDD:275380 6/100 (6%)
LRR 21 587..608 7/20 (35%)
leucine-rich repeat 588..611 CDD:275380 7/22 (32%)
LRR 22 611..632 7/20 (35%)
leucine-rich repeat 612..630 CDD:275380 7/17 (41%)
leucine-rich repeat 637..659 CDD:275380 5/46 (11%)
LRRCT 645..697 CDD:214507 10/69 (14%)
Tlr3_TMD 698..730 CDD:407816 7/44 (16%)
TIR 755..900 CDD:214587 28/108 (26%)
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 19/72 (26%)
leucine-rich repeat 136..159 CDD:275380 5/28 (18%)
leucine-rich repeat 160..190 CDD:275380 6/30 (20%)
LRR_8 189..259 CDD:290566 20/69 (29%)
leucine-rich repeat 191..214 CDD:275380 7/22 (32%)
leucine-rich repeat 215..248 CDD:275380 9/32 (28%)
LRR_RI 247..501 CDD:238064 71/294 (24%)
LRR_8 247..308 CDD:290566 16/60 (27%)
leucine-rich repeat 249..273 CDD:275380 4/23 (17%)
leucine-rich repeat 274..297 CDD:275380 7/22 (32%)
LRR_8 297..356 CDD:290566 20/88 (23%)
leucine-rich repeat 298..321 CDD:275380 9/25 (36%)
leucine-rich repeat 322..345 CDD:275380 7/40 (18%)
LRR_8 345..406 CDD:290566 21/71 (30%)
leucine-rich repeat 346..371 CDD:275380 11/35 (31%)
leucine-rich repeat 372..395 CDD:275380 7/22 (32%)
leucine-rich repeat 396..419 CDD:275380 6/22 (27%)
LRR_8 419..478 CDD:290566 19/67 (28%)
leucine-rich repeat 420..443 CDD:275380 8/31 (26%)
leucine-rich repeat 444..467 CDD:275380 5/22 (23%)
LRR_RI 466..622 CDD:238064 32/156 (21%)
leucine-rich repeat 468..488 CDD:275380 5/19 (26%)
LRR_8 491..549 CDD:290566 12/58 (21%)
leucine-rich repeat 491..514 CDD:275380 5/23 (22%)
leucine-rich repeat 515..536 CDD:275380 0/20 (0%)
leucine-rich repeat 539..562 CDD:275380 10/22 (45%)
leucine-rich repeat 563..585 CDD:275380 5/21 (24%)
leucine-rich repeat 586..626 CDD:275380 6/39 (15%)
leucine-rich repeat 627..653 CDD:275380 5/26 (19%)
LRRCT 716..772 CDD:214507 7/56 (13%)
LRRNT 796..830 CDD:214470 0/33 (0%)
leucine-rich repeat 812..829 CDD:275380 0/16 (0%)
leucine-rich repeat 833..854 CDD:275380 5/23 (22%)
LRR_8 853..913 CDD:290566 14/59 (24%)
leucine-rich repeat 855..878 CDD:275380 2/22 (9%)
LRR_4 878..918 CDD:289563 13/39 (33%)
leucine-rich repeat 879..902 CDD:275380 7/22 (32%)
leucine-rich repeat 903..926 CDD:275380 8/22 (36%)
leucine-rich repeat 927..953 CDD:275380 2/25 (8%)
TIR 1098..1235 CDD:214587 27/105 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.880

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