Protein Alignment TLR3 and lbk

DIOPT Version :10

• Sequence 1: NP_003256.1
• Gene: TLR3 / 7098
• HGNCID: 11849
• Length: 904
• Species: Homo sapiens
• Sequence 2: NP_611091.2
• Gene: lbk / 36788
• FlyBaseID: FBgn0034083
• Length: 1252
• Species: Drosophila melanogaster
• Alignment Length: 681
• Identity: 161/681 - (23%)
• Similarity: 237/681 - (34%)
• Gaps: 243/681 - (35%)

Human    28 CTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEP 92
            |...:.:.||..|.|.:|| .||:.:..|:|.:|:|.............||.:.:..|.:
  Fly   269 CKCLNVLFDCDKLHLERVP-VLPSYVQTLHLANNKLNDTTVLEIRNLLNLTKVSLKRNLL----- 327

Human    93 ELCQK---LPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDL 154
            |:..|   |..||.|.|.:|.::.:|.::.|....|..|.|..|.:..|:.|.|.|..||:.|.|
  Fly   328 EVIPKFIGLSGLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVHLIL 392

Human   155 SHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFAN-SSLKKLELSSNQIKEFSPGCFH 218
            |.|.:::....:...|.||.:|.||||::..|   .:.:|.| :.||||.|:.||::
  Fly   393 SFNEITNVNEHSFATLNNLTDLELSNNRLSTL---PIRVFKNLNQLKKLALNFNQLE-------- 446

Human   219 AIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSY 283
                                       .|.|                 ||.||:  ::..|.|..
  Fly   447 ---------------------------INWS-----------------TFRGLE--SMKNLQLKS 465

Human   284 NNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDD 348
            |.:..:.:..|..:.::|...|..|.|..|   |..||||:         ||
  Fly   466 NKIRALQDGVFYVMHKIETIDLAMNQISSL---SRQGLFNL---------TK------------- 505

Human   349 FSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILN 413
                    |.|||:                          ||
  Fly   506 --------LRHLNL--------------------------SF----------------------- 513

Human   414 LTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFAL 478
               |.||:||.|.:.:...||||||..|.| .|...|....|..:..:.|::|:...|..|:|..
  Fly   514 ---NAISRIEVDTWEFTQSLEVLDLSNNAI-NEFKPQHLDCLHRLKTLNLAHNRLQYLQENTFDC 574

Human   479 VPSLQRLMLRRVALKNV---DSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHN 540
            |.:|:.|.|||..|..:   .|:.:||:.||.|..|||..||:..|:...:.||..||
  Fly   575 VKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLE------- 632

Human   541 NLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASV 605
                                     ||||.||....|.|..|:.:..|
  Fly   633 -------------------------ILNLGSNALASIQVNAFEHMLRL----------------- 655

Human   606 FNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPE 670
              |::..||||                              |.|.|: :.||..|:.   ...|:
  Fly   656 --NKLVFKSLN------------------------------FICDCD-LVWFQQWLK---NRFPQ 684

Human   671 LSSHYLCNTPPHYHGFPVRLFDTSS--CKDS 699
            .:.|.:|..|.|.....::...:|.  |.||
  Fly   685 QAEHAVCGYPEHLLDRHLKSLSSSELVCVDS 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TLR3	NP_003256.1	leucine-rich repeat	33..52	CDD:275380	8/18 (44%)
		LRR	<36..309	CDD:443914	69/276 (25%)
		LRR 1	52..73		4/20 (20%)
		leucine-rich repeat	53..76	CDD:275380	4/22 (18%)
		LRR 2	76..97		4/20 (20%)
		leucine-rich repeat	77..100	CDD:275380	6/25 (24%)
		LRR 3	100..121		6/20 (30%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		LRR 4	124..145		7/20 (35%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		LRR 5	148..168		6/19 (32%)
		leucine-rich repeat	149..198	CDD:275380	16/49 (33%)
		LRR 6	172..193		8/20 (40%)
		LRR 7	198..219		7/20 (35%)
		leucine-rich repeat	199..249	CDD:275380	8/49 (16%)
		LRR 8	222..244		0/21 (0%)
		LRR 9	249..270		3/20 (15%)
		leucine-rich repeat	250..275	CDD:275380	4/24 (17%)
		LRR 10	275..296		4/20 (20%)
		leucine-rich repeat	276..299	CDD:275380	4/22 (18%)
		LRR	284..>630	CDD:443914	80/348 (23%)
		LRR 11	299..320		6/20 (30%)
		leucine-rich repeat	300..321	CDD:275380	6/20 (30%)
		LRR 12	323..344		3/20 (15%)
		LRR 13	356..377		4/20 (20%)
		leucine-rich repeat	357..380	CDD:275380	4/22 (18%)
		LRR 14	380..400		2/19 (11%)
		leucine-rich repeat	381..406	CDD:275380	2/24 (8%)
		LRR 15	408..429		6/20 (30%)
		leucine-rich repeat	409..432	CDD:275380	6/22 (27%)
		LRR 16	432..454		10/21 (48%)
		leucine-rich repeat	433..457	CDD:275380	11/23 (48%)
		leucine-rich repeat	458..481	CDD:275380	6/22 (27%)
		LRR 17	465..486		6/20 (30%)
		leucine-rich repeat	482..507	CDD:275380	10/27 (37%)
		LRR 18	507..528		7/20 (35%)
		leucine-rich repeat	508..531	CDD:275380	9/22 (41%)
		LRR 19	531..552		2/20 (10%)
		leucine-rich repeat	532..563	CDD:275380	2/30 (7%)
		LRR 20	563..584		9/20 (45%)
		leucine-rich repeat	564..585	CDD:275380	9/20 (45%)
		LRR 21	587..608		1/20 (5%)
		leucine-rich repeat	588..611	CDD:275380	2/22 (9%)
		LRR 22	611..632		4/20 (20%)
		leucine-rich repeat	612..630	CDD:275380	4/17 (24%)
		leucine-rich repeat	637..659	CDD:275380	5/21 (24%)
		LRRCT	645..697	CDD:214507	12/53 (23%)
		Tlr3_TMD	698..730	CDD:465595	2/2 (100%)
		TIR	755..900	CDD:214587
lbk	NP_611091.2	LRR	<293..642	CDD:443914	128/528 (24%)
		leucine-rich repeat	293..316	CDD:275380	4/22 (18%)
		leucine-rich repeat	317..338	CDD:275380	6/25 (24%)
		leucine-rich repeat	339..362	CDD:275380	7/22 (32%)
		leucine-rich repeat	363..386	CDD:275380	8/22 (36%)
		leucine-rich repeat	387..410	CDD:275380	6/22 (27%)
		leucine-rich repeat	411..434	CDD:275380	9/25 (36%)
		leucine-rich repeat	435..457	CDD:275380	13/75 (17%)
		leucine-rich repeat	458..481	CDD:275380	4/22 (18%)
		leucine-rich repeat	482..505	CDD:275380	10/34 (29%)
		leucine-rich repeat	506..529	CDD:275380	12/74 (16%)
		leucine-rich repeat	530..553	CDD:275380	11/23 (48%)
		leucine-rich repeat	554..577	CDD:275380	6/22 (27%)
		leucine-rich repeat	578..604	CDD:275380	9/25 (36%)
		leucine-rich repeat	607..630	CDD:275380	9/22 (41%)
		leucine-rich repeat	631..652	CDD:275380	11/52 (21%)
		LRRCT	665..712	CDD:214507	12/50 (24%)
		Ig_3	717..816	CDD:464046
		Ig	835..924	CDD:472250
		Ig strand B	851..855	CDD:409353
		Ig strand C	864..868	CDD:409353
		Ig strand E	890..894	CDD:409353
		Ig strand F	904..909	CDD:409353
		Ig strand G	917..920	CDD:409353
		Ig_3	927..1013	CDD:464046