DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR3 and Tehao

DIOPT Version :9

Sequence 1:NP_003256.1 Gene:TLR3 / 7098 HGNCID:11849 Length:904 Species:Homo sapiens
Sequence 2:NP_001285901.1 Gene:Tehao / 34761 FlyBaseID:FBgn0026760 Length:795 Species:Drosophila melanogaster


Alignment Length:986 Identity:198/986 - (20%)
Similarity:339/986 - (34%) Gaps:292/986 - (29%)


- Green bases have known domain annotations that are detailed below.


Human     5 LPCIYFW----------GGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLT 59
            ||.::.:          |.::|....|...:.:||.:.|    .::.....||:....:.|..  
  Fly     5 LPVVWLFFALLVLRSATGQIIPLPTFCLGLSPQCTCAAE----GNVVRFHCPDEYAMLLEVSE-- 63

Human    60 HNQLRRLPAAN-FTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCT 123
                   |.|: :..|...|.|               |.||...:.:|...|..........|.:
  Fly    64 -------PGASLYMSYYASTEL---------------QWLPRFNISSLVKIEFDAYIFWPEKFLS 106

Human   124 NLTELHLMSNSIQKIKNNPFVKQ--KNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQAL 186
            :|    |.:..:|.:|...|..:  :.::|.|:.::|                     |..::..
  Fly   107 DL----LKTLGVQTVKTIIFRDRTLETVVTRDVLNSG---------------------NGYMETS 146

Human   187 KSEELDIFANSS---LKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANT 248
            :.|.:..:...|   |||.:..|: :.|.....||....|..|.|                    
  Fly   147 QPENITTWHFGSVPGLKKFKFFSH-VPELQESIFHGFDTLRDLHL-------------------- 190

Human   249 SIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHL 313
            |:...:|..:.|||.:.|         |..|.:....:...||.....|.||       .|:...
  Fly   191 SVNVTTLPGNMLSTVNGT---------LKTLTIESPGIVSFGNPLLRELQQL-------RNLSLA 239

Human   314 FSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGL 378
            ..|..|          :|....|.....|:..:::....            :....:..:||.|.
  Fly   240 LIHPFH----------ERDKQLQPHFFGSMTNLEEVRLA------------SATSSVNRSMFKGT 282

Human   379 INLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEI 443
            ..|:.:.: |....|..|..|.|:...:  |..|:|:.|.|..:..|.|..||:|.:||      
  Fly   283 NKLQLIKM-NGNDDLMELPGEIFLDQVN--LKTLDLSCNAIVTLHEDVFKGLGNLTLLD------ 338

Human   444 GQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNL 508
                               ||.|:...|:...||.:.||..|.|.:.:|..:  |||.||.:.:|
  Fly   339 -------------------LSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAM--SPSVFQDVVSL 382

Human   509 TILDLSNNN------------IANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGL 561
            ..:::.|..            :...||:..:    .:..:.|.:.....|...:.|..|...:|.
  Fly   383 NYIEMVNTQFYGATLLMNYEAVVCTNDEACQ----YKSAEWQCDPRCICWVQRSVGSLIVDCRGT 443

Human   562 SHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLP-ASVFNNQVSLKSLNLQKNLITSV 625
            |           .:|:| ::.:......::.:|.|:|.:|| .|..:...::..|.|..|.:||:
  Fly   444 S-----------LEELP-DLPRTTLLSTVLKVGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSL 496

Human   626 EKKVFGPAFRNLTELDMR---------------------------FNPFDCTCESIA--WFVNWI 661
            ......|  .|||.||:|                           .||..|.|||::  :||   
  Fly   497 GSGDQLP--DNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLLFFV--- 556

Human   662 NETHTNIPELSSHYLCNTPPHYHGFPVRLFD------TSSCKDSAPFELFFMINTSILLI----- 715
               .||                   |.|:.|      |...|.....|.|.:..:.:|||     
  Fly   557 ---RTN-------------------PQRVRDIADIVCTKQKKSFQQMEAFELCPSYVLLISCVVG 599

Human   716 --FIFIVLLIHF-----EGWRISFY------WNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDK 767
              .|.|.||..|     :..:|..|      |.||.      :|:|:..   .|.|:|.:::||:
  Fly   600 GLVIVICLLTVFYLMFQQELKIWLYNNNLCLWWVSE------EELDKDK---TYDAFISYSHKDE 655

Human   768 DWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKV 832
            :.:.:....:|......:.||.:||:..|....|.||.::..|:::|.|::.|.: |.:..|.:.
  Fly   656 ELISKLLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFI-DSVWARMEF 719

Human   833 HHAVQQAIEQNLDSIILVFLEEIP-----DYKLNHALCLRRGMFKSHCILNW--PVQKERI-GAF 889
            ..|.|..::.....||::...|:.     |.:|       |...|.:..|.|  |:...:: .|.
  Fly   720 RIAYQATLQDKRKRIIIILYRELEHMNGIDSEL-------RAYLKLNTYLKWGDPLFWSKLYYAM 777

Human   890 RHKLQVALGSK 900
            .|..:|..|.|
  Fly   778 PHNRRVLKGQK 788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR3NP_003256.1 LRRNT 28..50 CDD:396168 5/21 (24%)
leucine-rich repeat 33..52 CDD:275380 3/18 (17%)
LRR 1 52..73 3/21 (14%)
leucine-rich repeat 53..76 CDD:275380 4/23 (17%)
PLN00113 72..>542 CDD:215061 91/486 (19%)
LRR 2 76..97 2/20 (10%)
leucine-rich repeat 77..100 CDD:275380 4/22 (18%)
LRR 3 100..121 2/20 (10%)
leucine-rich repeat 101..124 CDD:275380 3/22 (14%)
LRR 4 124..145 5/20 (25%)
leucine-rich repeat 125..148 CDD:275380 5/24 (21%)
LRR 5 148..168 3/19 (16%)
leucine-rich repeat 149..198 CDD:275380 5/48 (10%)
LRR 6 172..193 2/20 (10%)
LRR 7 198..219 7/23 (30%)
leucine-rich repeat 199..249 CDD:275380 10/49 (20%)
LRR 8 222..244 3/21 (14%)
LRR 9 249..270 6/20 (30%)
leucine-rich repeat 250..275 CDD:275380 5/24 (21%)
LRR 10 275..296 4/20 (20%)
leucine-rich repeat 276..299 CDD:275380 5/22 (23%)
LRR 11 299..320 4/20 (20%)
leucine-rich repeat 300..321 CDD:275380 4/20 (20%)
LRR 12 323..344 3/20 (15%)
LRR 13 356..377 2/20 (10%)
leucine-rich repeat 357..380 CDD:275380 3/22 (14%)
LRR 14 380..400 4/19 (21%)
leucine-rich repeat 381..406 CDD:275380 6/24 (25%)
LRR 15 408..429 7/20 (35%)
leucine-rich repeat 409..432 CDD:275380 8/22 (36%)
LRR 16 432..454 3/21 (14%)
leucine-rich repeat 433..457 CDD:275380 3/23 (13%)
leucine-rich repeat 458..481 CDD:275380 6/22 (27%)
LRR 17 465..486 6/20 (30%)
leucine-rich repeat 482..507 CDD:275380 9/24 (38%)
LRR 18 507..528 4/32 (13%)
leucine-rich repeat 508..531 CDD:275380 4/34 (12%)
LRR 19 531..552 2/20 (10%)
leucine-rich repeat 532..563 CDD:275380 5/30 (17%)
LRR_8 562..622 CDD:404697 12/60 (20%)
LRR 20 563..584 2/20 (10%)
leucine-rich repeat 564..585 CDD:275380 2/20 (10%)
LRR 21 587..608 6/21 (29%)
leucine-rich repeat 588..611 CDD:275380 6/23 (26%)
LRR 22 611..632 5/20 (25%)
leucine-rich repeat 612..630 CDD:275380 5/17 (29%)
leucine-rich repeat 637..659 CDD:275380 12/50 (24%)
LRRCT 645..697 CDD:214507 14/59 (24%)
Tlr3_TMD 698..730 CDD:407816 10/43 (23%)
TIR 755..900 CDD:214587 36/152 (24%)
TehaoNP_001285901.1 leucine-rich repeat 185..207 CDD:275380 8/41 (20%)
leucine-rich repeat 209..232 CDD:275380 5/22 (23%)
leucine-rich repeat 233..261 CDD:275380 7/44 (16%)
LRR_RI <261..370 CDD:238064 32/148 (22%)
leucine-rich repeat 262..284 CDD:275380 3/33 (9%)
leucine-rich repeat 285..309 CDD:275380 6/24 (25%)
LRR_8 309..368 CDD:290566 22/85 (26%)
leucine-rich repeat 310..333 CDD:275380 8/22 (36%)
leucine-rich repeat 334..357 CDD:275380 9/47 (19%)
leucine-rich repeat 358..381 CDD:275380 9/24 (38%)
leucine-rich repeat 445..482 CDD:275380 8/37 (22%)
LRR_8 459..516 CDD:290566 18/58 (31%)
leucine-rich repeat 483..505 CDD:275380 6/23 (26%)
LRR_4 486..521 CDD:289563 12/36 (33%)
TIR 643..779 CDD:214587 33/143 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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