DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR3 and Tehao

DIOPT Version :10

Sequence 1:NP_003256.1 Gene:TLR3 / 7098 HGNCID:11849 Length:904 Species:Homo sapiens
Sequence 2:NP_477438.1 Gene:Tehao / 34761 FlyBaseID:FBgn0026760 Length:795 Species:Drosophila melanogaster


Alignment Length:986 Identity:198/986 - (20%)
Similarity:339/986 - (34%) Gaps:292/986 - (29%)


- Green bases have known domain annotations that are detailed below.


Human     5 LPCIYFW----------GGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLT 59
            ||.::.:          |.::|....|...:.:||.:.|    .::.....||:....:.|..  
  Fly     5 LPVVWLFFALLVLRSATGQIIPLPTFCLGLSPQCTCAAE----GNVVRFHCPDEYAMLLEVSE-- 63

Human    60 HNQLRRLPAAN-FTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCT 123
                   |.|: :..|...|.|               |.||...:.:|...|..........|.:
  Fly    64 -------PGASLYMSYYASTEL---------------QWLPRFNISSLVKIEFDAYIFWPEKFLS 106

Human   124 NLTELHLMSNSIQKIKNNPFVKQ--KNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQAL 186
            :|    |.:..:|.:|...|..:  :.::|.|:.::|                     |..::..
  Fly   107 DL----LKTLGVQTVKTIIFRDRTLETVVTRDVLNSG---------------------NGYMETS 146

Human   187 KSEELDIFANSS---LKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANT 248
            :.|.:..:...|   |||.:..|: :.|.....||....|..|.|                    
  Fly   147 QPENITTWHFGSVPGLKKFKFFSH-VPELQESIFHGFDTLRDLHL-------------------- 190

Human   249 SIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHL 313
            |:...:|..:.|||.:.|         |..|.:....:...||.....|.||       .|:...
  Fly   191 SVNVTTLPGNMLSTVNGT---------LKTLTIESPGIVSFGNPLLRELQQL-------RNLSLA 239

Human   314 FSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGL 378
            ..|..|          :|....|.....|:..:::....            :....:..:||.|.
  Fly   240 LIHPFH----------ERDKQLQPHFFGSMTNLEEVRLA------------SATSSVNRSMFKGT 282

Human   379 INLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEI 443
            ..|:.:.: |....|..|..|.|:...:  |..|:|:.|.|..:..|.|..||:|.:||      
  Fly   283 NKLQLIKM-NGNDDLMELPGEIFLDQVN--LKTLDLSCNAIVTLHEDVFKGLGNLTLLD------ 338

Human   444 GQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNL 508
                               ||.|:...|:...||.:.||..|.|.:.:|..:  |||.||.:.:|
  Fly   339 -------------------LSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAM--SPSVFQDVVSL 382

Human   509 TILDLSNNN------------IANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGL 561
            ..:::.|..            :...||:..:    .:..:.|.:.....|...:.|..|...:|.
  Fly   383 NYIEMVNTQFYGATLLMNYEAVVCTNDEACQ----YKSAEWQCDPRCICWVQRSVGSLIVDCRGT 443

Human   562 SHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLP-ASVFNNQVSLKSLNLQKNLITSV 625
            |           .:|:| ::.:......::.:|.|:|.:|| .|..:...::..|.|..|.:||:
  Fly   444 S-----------LEELP-DLPRTTLLSTVLKVGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSL 496

Human   626 EKKVFGPAFRNLTELDMR---------------------------FNPFDCTCESIA--WFVNWI 661
            ......|  .|||.||:|                           .||..|.|||::  :||   
  Fly   497 GSGDQLP--DNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLLFFV--- 556

Human   662 NETHTNIPELSSHYLCNTPPHYHGFPVRLFD------TSSCKDSAPFELFFMINTSILLI----- 715
               .||                   |.|:.|      |...|.....|.|.:..:.:|||     
  Fly   557 ---RTN-------------------PQRVRDIADIVCTKQKKSFQQMEAFELCPSYVLLISCVVG 599

Human   716 --FIFIVLLIHF-----EGWRISFY------WNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDK 767
              .|.|.||..|     :..:|..|      |.||.      :|:|:..   .|.|:|.:::||:
  Fly   600 GLVIVICLLTVFYLMFQQELKIWLYNNNLCLWWVSE------EELDKDK---TYDAFISYSHKDE 655

Human   768 DWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKV 832
            :.:.:....:|......:.||.:||:..|....|.||.::..|:::|.|::.|.: |.:..|.:.
  Fly   656 ELISKLLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFI-DSVWARMEF 719

Human   833 HHAVQQAIEQNLDSIILVFLEEIP-----DYKLNHALCLRRGMFKSHCILNW--PVQKERI-GAF 889
            ..|.|..::.....||::...|:.     |.:|       |...|.:..|.|  |:...:: .|.
  Fly   720 RIAYQATLQDKRKRIIIILYRELEHMNGIDSEL-------RAYLKLNTYLKWGDPLFWSKLYYAM 777

Human   890 RHKLQVALGSK 900
            .|..:|..|.|
  Fly   778 PHNRRVLKGQK 788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR3NP_003256.1 leucine-rich repeat 33..52 CDD:275380 3/18 (17%)
LRR <36..309 CDD:443914 48/278 (17%)
LRR 1 52..73 3/21 (14%)
leucine-rich repeat 53..76 CDD:275380 4/23 (17%)
LRR 2 76..97 2/20 (10%)
leucine-rich repeat 77..100 CDD:275380 4/22 (18%)
LRR 3 100..121 2/20 (10%)
leucine-rich repeat 101..124 CDD:275380 3/22 (14%)
LRR 4 124..145 5/20 (25%)
leucine-rich repeat 125..148 CDD:275380 5/24 (21%)
LRR 5 148..168 3/19 (16%)
leucine-rich repeat 149..198 CDD:275380 5/48 (10%)
LRR 6 172..193 2/20 (10%)
LRR 7 198..219 7/23 (30%)
leucine-rich repeat 199..249 CDD:275380 10/49 (20%)
LRR 8 222..244 3/21 (14%)
LRR 9 249..270 6/20 (30%)
leucine-rich repeat 250..275 CDD:275380 5/24 (21%)
LRR 10 275..296 4/20 (20%)
leucine-rich repeat 276..299 CDD:275380 5/22 (23%)
LRR 284..>630 CDD:443914 71/358 (20%)
LRR 11 299..320 4/20 (20%)
leucine-rich repeat 300..321 CDD:275380 4/20 (20%)
LRR 12 323..344 3/20 (15%)
LRR 13 356..377 2/20 (10%)
leucine-rich repeat 357..380 CDD:275380 3/22 (14%)
LRR 14 380..400 4/19 (21%)
leucine-rich repeat 381..406 CDD:275380 6/24 (25%)
LRR 15 408..429 7/20 (35%)
leucine-rich repeat 409..432 CDD:275380 8/22 (36%)
LRR 16 432..454 3/21 (14%)
leucine-rich repeat 433..457 CDD:275380 3/23 (13%)
leucine-rich repeat 458..481 CDD:275380 6/22 (27%)
LRR 17 465..486 6/20 (30%)
leucine-rich repeat 482..507 CDD:275380 9/24 (38%)
LRR 18 507..528 4/32 (13%)
leucine-rich repeat 508..531 CDD:275380 4/34 (12%)
LRR 19 531..552 2/20 (10%)
leucine-rich repeat 532..563 CDD:275380 5/30 (17%)
LRR 20 563..584 2/20 (10%)
leucine-rich repeat 564..585 CDD:275380 2/20 (10%)
LRR 21 587..608 6/21 (29%)
leucine-rich repeat 588..611 CDD:275380 6/23 (26%)
LRR 22 611..632 5/20 (25%)
leucine-rich repeat 612..630 CDD:275380 5/17 (29%)
leucine-rich repeat 637..659 CDD:275380 12/50 (24%)
LRRCT 645..697 CDD:214507 14/59 (24%)
Tlr3_TMD 698..730 CDD:465595 10/43 (23%)
TIR 755..900 CDD:214587 36/152 (24%)
TehaoNP_477438.1 LRR 184..>541 CDD:443914 89/462 (19%)
leucine-rich repeat 185..207 CDD:275380 8/41 (20%)
leucine-rich repeat 209..232 CDD:275380 5/22 (23%)
leucine-rich repeat 233..261 CDD:275380 7/44 (16%)
leucine-rich repeat 262..284 CDD:275380 3/33 (9%)
leucine-rich repeat 285..309 CDD:275380 6/24 (25%)
leucine-rich repeat 310..333 CDD:275380 8/22 (36%)
leucine-rich repeat 334..357 CDD:275380 9/47 (19%)
leucine-rich repeat 358..381 CDD:275380 9/24 (38%)
leucine-rich repeat 445..482 CDD:275380 8/37 (22%)
leucine-rich repeat 483..505 CDD:275380 6/23 (26%)
TIR 643..779 CDD:214587 33/143 (23%)

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