DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR3 and Toll-4

DIOPT Version :10

Sequence 1:NP_003256.1 Gene:TLR3 / 7098 HGNCID:11849 Length:904 Species:Homo sapiens
Sequence 2:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster


Alignment Length:955 Identity:211/955 - (22%)
Similarity:344/955 - (36%) Gaps:326/955 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    27 KCTVSH-------EVADCSHLKLTQVPDDLPT---NITVLNLTHNQLRRLPAANFTRYSQLTSLD 81
            ||..|:       |: ||....||.:| .||.   ..:.|....|.|..||..:...|..|.|||
  Fly   375 KCNCSYNRDKSQLEI-DCWQKNLTTIP-SLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLD 437

Human    82 VGFNTISKLEPELCQKLP-MLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVK 145
            |.:|.::.|.   ..:|| .|..|:::||:::.||.:...:..::...:...|            
  Fly   438 VSYNQLTSLS---VSQLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGN------------ 487

Human   146 QKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIK 210
             |..|..|..|                |||......|:..:|:.:.    .:.::.:||||.   
  Fly   488 -KWSIYCDEYH----------------LQEFFWYKAKLLRIKTSKF----QTIMEYIELSSK--- 528

Human   211 EFSPGCFHAIGRLFGLFLNN--VQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKW 273
                          |.|:.|  ||                                         
  Fly   529 --------------GSFVENFFVQ----------------------------------------- 538

Human   274 TNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLE----YNNIQHLFSHSLHGLFN---VRYLNLKR 331
             |:..|.|..|...::  |:|.  |..:||.|:    .|:...|||    |.|:   :.:||   
  Fly   539 -NIDQLYLEANEDEII--DAFG--PSDKYFNLKLMEALNHAIWLFS----GEFDEIILHHLN--- 591

Human   332 SFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTG--LINLKYLSLS------N 388
                     :..|......|:|                     .||  |||.:.|||.      |
  Fly   592 ---------SPCPYRCSCCFEW---------------------HTGEFLINCRNLSLDIYPRLPN 626

Human   389 SF----------TSLRTLTN-ETFVSLAHSPLHILNLTKNKISKIE----SDAFSWL----GHLE 434
            |.          ..:|.||| |:.|...|:.:|.|::::|.:.::.    .:..::|    ..|:
  Fly   627 SIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLK 691

Human   435 VLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQR-------LMLRRVAL 492
            .||.|:      :...|:|  |||.:|.||.|.: :....:.|.:..|:|       .:||||.:
  Fly   692 YLDDGV------IAFLEYR--ENITKIELSGNPW-ECNCKAKAFLSFLRRHEPMEYETVLRRVEI 747

Human   493 KNVDSSPSPFQPLRNLTILDLSN-NNIANINDDMLEGLEKLEI------------LDLQHNNLAR 544
            .: |..|...     :..:|.|| :::|.:.|  ..|.|..||            |..:.|:|.:
  Fly   748 TD-DKCPEDC-----ICCVDTSNSDSLAYVVD--CSGKELSEIPQLPTPTYGQTTLVFERNSLKK 804

Human   545 LWKHANPGGPIYFLKGLSHLHILNLESN---GFDEIPVEVFKDLFELKIIDLGLNNLNTLPASV- 605
             |       |...|.|.|.:....|..|   ..|::|       .:|:.:|:..||.:.|...| 
  Fly   805 -W-------PSSLLPGYSSVTRFYLAHNRLSDIDQLP-------DKLEYLDISNNNFSALDDRVR 854

Human   606 -FNNQVSLKSLNLQKNLITS-VEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNI 668
             |          |||.:.:| ::..:||             ||:.|.||...:.| ::.|...||
  Fly   855 GF----------LQKRMNSSQLQLSLFG-------------NPWTCRCEDKDFLV-FVKEQAKNI 895

Human   669 PELSSHYLCNTPPHYHGFPVRLFDTSSC------KDSAPFELFF--MINTSILLIFIFIVLLIHF 725
            ...|:              ::..||...      .|..|..|.:  .:..|:|:|.:.|.:.|.|
  Fly   896 ANASA--------------IQCIDTGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVFICF 946

Human   726 -EGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLE 789
             :...|.||.:.....:...:|:|   |..:|.|::...:||:|.:.|....:|......:.|..
  Fly   947 RQPIMIWFYEHEICLSLAARRELD---EDKKYDAFLSFTHKDEDLIEEFVDRLENGRHKFRLCFY 1008

Human   790 ERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKD----------------PLCKRFKVHHAVQQ 838
            .||:..|....:.|..|:|.||:||.::|.:.||.                ..|||..|  .:..
  Fly  1009 LRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIV--VLYP 1071

Human   839 AIE--QNLDSIILVFL-------EEIPD------YKLNHALCLRR 868
            .:|  .:|||.:..::       ...|:      |.:.||..|:|
  Fly  1072 DVEHFDDLDSELRAYMVLNTYLDRNNPNFWNKLMYSMPHASHLKR 1116

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR3NP_003256.1 leucine-rich repeat 33..52 CDD:275380 8/21 (38%)
LRR <36..309 CDD:443914 57/282 (20%)
LRR 1 52..73 5/20 (25%)
leucine-rich repeat 53..76 CDD:275380 6/22 (27%)
LRR 2 76..97 7/20 (35%)
leucine-rich repeat 77..100 CDD:275380 9/23 (39%)
LRR 3 100..121 6/20 (30%)
leucine-rich repeat 101..124 CDD:275380 6/22 (27%)
LRR 4 124..145 1/20 (5%)
leucine-rich repeat 125..148 CDD:275380 1/22 (5%)
LRR 5 148..168 3/19 (16%)
leucine-rich repeat 149..198 CDD:275380 8/48 (17%)
LRR 6 172..193 5/20 (25%)
LRR 7 198..219 4/20 (20%)
leucine-rich repeat 199..249 CDD:275380 9/51 (18%)
LRR 8 222..244 5/23 (22%)
LRR 9 249..270 0/20 (0%)
leucine-rich repeat 250..275 CDD:275380 0/24 (0%)
LRR 10 275..296 6/20 (30%)
leucine-rich repeat 276..299 CDD:275380 5/22 (23%)
LRR 284..>630 CDD:443914 93/405 (23%)
LRR 11 299..320 7/24 (29%)
leucine-rich repeat 300..321 CDD:275380 7/24 (29%)
LRR 12 323..344 2/23 (9%)
LRR 13 356..377 0/20 (0%)
leucine-rich repeat 357..380 CDD:275380 3/24 (13%)
LRR 14 380..400 10/36 (28%)
leucine-rich repeat 381..406 CDD:275380 11/41 (27%)
LRR 15 408..429 3/24 (13%)
leucine-rich repeat 409..432 CDD:275380 4/30 (13%)
LRR 16 432..454 5/21 (24%)
leucine-rich repeat 433..457 CDD:275380 6/23 (26%)
leucine-rich repeat 458..481 CDD:275380 6/22 (27%)
LRR 17 465..486 4/27 (15%)
leucine-rich repeat 482..507 CDD:275380 8/31 (26%)
LRR 18 507..528 5/21 (24%)
leucine-rich repeat 508..531 CDD:275380 6/23 (26%)
LRR 19 531..552 6/32 (19%)
leucine-rich repeat 532..563 CDD:275380 9/42 (21%)
LRR 20 563..584 4/23 (17%)
leucine-rich repeat 564..585 CDD:275380 4/23 (17%)
LRR 21 587..608 7/22 (32%)
leucine-rich repeat 588..611 CDD:275380 7/24 (29%)
LRR 22 611..632 5/21 (24%)
leucine-rich repeat 612..630 CDD:275380 4/18 (22%)
leucine-rich repeat 637..659 CDD:275380 5/21 (24%)
LRRCT 645..697 CDD:214507 12/57 (21%)
Tlr3_TMD 698..730 CDD:465595 9/34 (26%)
TIR 755..900 CDD:214587 35/145 (24%)
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 31/99 (31%)
leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..386 CDD:275380 3/10 (30%)
PRK15370 <381..>482 CDD:185268 29/105 (28%)
leucine-rich repeat 388..408 CDD:275380 8/21 (38%)
leucine-rich repeat 412..432 CDD:275378 6/19 (32%)
LRR <416..591 CDD:443914 55/277 (20%)
leucine-rich repeat 433..454 CDD:275378 9/23 (39%)
leucine-rich repeat 455..478 CDD:275378 6/22 (27%)
leucine-rich repeat 479..490 CDD:275378 2/23 (9%)
leucine-rich repeat 632..657 CDD:275378 7/24 (29%)
leucine-rich repeat 658..679 CDD:275378 3/20 (15%)
leucine-rich repeat 680..706 CDD:275378 7/33 (21%)
PCC 684..>771 CDD:188093 26/101 (26%)
leucine-rich repeat 707..719 CDD:275378 5/12 (42%)
leucine-rich repeat 771..791 CDD:275380 5/21 (24%)
PRK15370 <793..>877 CDD:185268 27/121 (22%)
leucine-rich repeat 793..815 CDD:275378 7/29 (24%)
leucine-rich repeat 816..835 CDD:275378 4/25 (16%)
leucine-rich repeat 836..859 CDD:275378 8/32 (25%)
TIR 974..1110 CDD:214587 31/137 (23%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.