DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR3 and CG42346

DIOPT Version :10

Sequence 1:NP_003256.1 Gene:TLR3 / 7098 HGNCID:11849 Length:904 Species:Homo sapiens
Sequence 2:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster


Alignment Length:939 Identity:227/939 - (24%)
Similarity:393/939 - (41%) Gaps:172/939 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    39 HLKLTQVPDD-LPTNITVLNL-THNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPML 101
            ||::.::.:: :||....:.| |:|......|....:...|..||:..|..:::.|:..:..|.|
  Fly   422 HLRILRLSNNRIPTFYGDIQLATNNASAAAAAVGAFQLPSLIFLDLSSNQFAEIGPDCFRAFPQL 486

Human   102 KVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGT 166
            |.|:...|::..:..:.|.....|..|.:..|.|..:....|.|.|.|.|:|||||.: .|..|.
  Fly   487 KTLSFYANQIELVQPEAFKSLRELMSLDMSHNRIIGLDPKVFEKNKRLQTVDLSHNHI-HTIGGV 550

Human   167 QVQLENLQELLLSNNKIQALKSEELDIFANS-SLKKLELSSNQIKEFSPGCFHAIGRLFGLFL-- 228
            ...|..|:|:.||.|.|..|.:   |.|.|| ::..:.|.||.|....|..|..:..|..|:|  
  Fly   551 FSNLPQLREVFLSENNILELPA---DAFTNSTNVDVIYLESNAIAHIDPNVFSTLVNLDHLYLRS 612

Human   229 NNVQLGP-SLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGND 292
            |.:.|.| :|.:|      :|.:.:|||.|:::.......|..|:  :|..:.|..|.:..|...
  Fly   613 NFIPLLPVTLFDK------STKLTSLSLDNNEIQDLEIGMFRKLE--HLREVRLHNNRIRRVRRG 669

Human   293 SFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRS--------FTKQSISLAS------- 342
            .|..||.|:...::.|:|:.:...:.|.|.|::::||:.:        |..::.||.|       
  Fly   670 VFEPLPSLQELHIQKNSIEDIEPQAFHTLENMQHINLQDNQLTVLEDIFPDENSSLLSVQLEANY 734

Human   343 LPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHS 407
            |.|:...:|...:.::.:.::||.:..::.:.|.....|..|.||::  .:|.:..:|||:|.  
  Fly   735 LHKVHPRTFSRQQKVQIMWLKDNQLTRVERSFFADTPQLGRLYLSDN--KIRDIEKDTFVNLL-- 795

Human   408 PLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLT 472
            .|..|:|:.|::.::..|.|:.|..||.|.|..|.| :.:.|..:..|:|:..:.||:|..:|||
  Fly   796 LLQFLDLSGNQLRQLRRDYFAPLQDLEELSLARNHI-EAIEGYAFAKLKNLKSLDLSHNPLVQLT 859

Human   473 RNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDL 537
            |:.|:....|..|.|...:|:.::.  ..|:.|.||..|:|..|.: |..|.....:..|..|.|
  Fly   860 RDIFSNEFPLNSLNLGNCSLRKLEQ--HAFKSLTNLNELNLERNQL-NPADIQTLDIPNLRRLLL 921

Human   538 QHNNLARLWKHANPGGPIYFLKGLSHLHI---------------------LNLESNGFDEIPVEV 581
            .|||.:.........|.:..|:.|..|.:                     |:|..|...:|...:
  Fly   922 SHNNFSYAGSVGIMAGMLDRLRSLQQLSMSNCSLGQIPDLLFAKNTNLVRLDLCDNRLTQINRNI 986

Human   582 FKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVE-KKVFGPAFRNLTELDMRFN 645
            |..|...|.:.|..|.|:..|.....|..:|:||:|.:|.:.|:: .|:.|..  ||.:|.:|.|
  Fly   987 FSGLNVFKELRLCRNELSDFPHIALYNLSTLESLDLARNQLASIDFFKLSGTL--NLRQLILRDN 1049

Human   646 PFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHY--HGFPVRLFDTSSCKDSAPFELFFMI 708
            ..    .:::.| |.:|.|..:..:||.:.|.:.|.::  |...::....|:.:       |..|
  Fly  1050 KI----TALSGF-NAVNLTQLDSVDLSGNLLLSLPANFLRHSINLQKVHLSNNR-------FLQI 1102

Human   709 NTSILL-IFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWE 772
            .:|.|. :.|..:..::..|..|:..:.|...|....||:           ||.           
  Fly  1103 PSSALSDVSIPRLSWLNLTGNPINRIYTVKEERYPYLKEL-----------YIC----------- 1145

Human   773 HFSSMEKEDQSLKFCLEERDFEA-------------------GVFE-------LEAIVNSIKR-- 809
                     |:....|..:||||                   |.|:       |:..||.::.  
  Fly  1146 ---------QTNLSILTSKDFEAFQALQHLHLVNNRITRISPGAFKSLTNLLTLDLSVNELEMLP 1201

Human   810 ------SRKIIFV-ITHHLLKDPLCKRFKVHHAVQQAIE--------------QNLDSIILVFL- 852
                  .|.:.|: |:|:.|||  .:.|.|.....|.::              :||..::.:|| 
  Fly  1202 KERLQGLRLLRFLNISHNTLKD--LEEFSVDLLEMQTLDLSFNQLDRISKKTFRNLHGLLELFLM 1264

Human   853 ---------EEIPDYKLNHALCLRRGMFK 872
                     :.....:..|.|.||:..|:
  Fly  1265 GNRMTVLSNDAFRFLRKLHVLDLRKNYFE 1293

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR3NP_003256.1 leucine-rich repeat 33..52 CDD:275380 3/13 (23%)
LRR <36..309 CDD:443914 76/275 (28%)
LRR 1 52..73 4/21 (19%)
leucine-rich repeat 53..76 CDD:275380 4/23 (17%)
LRR 2 76..97 5/20 (25%)
leucine-rich repeat 77..100 CDD:275380 5/22 (23%)
LRR 3 100..121 5/20 (25%)
leucine-rich repeat 101..124 CDD:275380 5/22 (23%)
LRR 4 124..145 5/20 (25%)
leucine-rich repeat 125..148 CDD:275380 6/22 (27%)
LRR 5 148..168 9/19 (47%)
leucine-rich repeat 149..198 CDD:275380 21/49 (43%)
LRR 6 172..193 7/20 (35%)
LRR 7 198..219 6/20 (30%)
leucine-rich repeat 199..249 CDD:275380 14/52 (27%)
LRR 8 222..244 8/24 (33%)
LRR 9 249..270 5/20 (25%)
leucine-rich repeat 250..275 CDD:275380 6/24 (25%)
LRR 10 275..296 5/20 (25%)
leucine-rich repeat 276..299 CDD:275380 6/22 (27%)
LRR 284..>630 CDD:443914 98/382 (26%)
LRR 11 299..320 3/20 (15%)
leucine-rich repeat 300..321 CDD:275380 4/20 (20%)
LRR 12 323..344 7/35 (20%)
LRR 13 356..377 3/20 (15%)
leucine-rich repeat 357..380 CDD:275380 3/22 (14%)
LRR 14 380..400 5/19 (26%)
leucine-rich repeat 381..406 CDD:275380 9/24 (38%)
LRR 15 408..429 6/20 (30%)
leucine-rich repeat 409..432 CDD:275380 7/22 (32%)
LRR 16 432..454 7/21 (33%)
leucine-rich repeat 433..457 CDD:275380 8/23 (35%)
leucine-rich repeat 458..481 CDD:275380 8/22 (36%)
LRR 17 465..486 7/20 (35%)
leucine-rich repeat 482..507 CDD:275380 6/24 (25%)
LRR 18 507..528 7/20 (35%)
leucine-rich repeat 508..531 CDD:275380 6/22 (27%)
LRR 19 531..552 6/20 (30%)
leucine-rich repeat 532..563 CDD:275380 9/30 (30%)
LRR 20 563..584 6/41 (15%)
leucine-rich repeat 564..585 CDD:275380 6/41 (15%)
LRR 21 587..608 5/20 (25%)
leucine-rich repeat 588..611 CDD:275380 6/22 (27%)
LRR 22 611..632 7/21 (33%)
leucine-rich repeat 612..630 CDD:275380 7/18 (39%)
leucine-rich repeat 637..659 CDD:275380 5/21 (24%)
LRRCT 645..697 CDD:214507 11/53 (21%)
Tlr3_TMD 698..730 CDD:465595 6/32 (19%)
TIR 755..900 CDD:214587 32/177 (18%)
CG42346NP_001036303.2 LRR <301..606 CDD:443914 53/187 (28%)
leucine-rich repeat 303..325 CDD:275380
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 351..461 CDD:275380 8/38 (21%)
leucine-rich repeat 399..422 CDD:275380 227/939 (24%)
leucine-rich repeat 462..485 CDD:275380 5/22 (23%)
LRR 486..>736 CDD:443914 73/261 (28%)
leucine-rich repeat 486..509 CDD:275380 5/22 (23%)
leucine-rich repeat 510..533 CDD:275380 6/22 (27%)
leucine-rich repeat 534..556 CDD:275380 10/22 (45%)
leucine-rich repeat 557..580 CDD:275380 11/25 (44%)
leucine-rich repeat 581..604 CDD:275380 6/22 (27%)
leucine-rich repeat 605..628 CDD:275380 8/28 (29%)
PPP1R42 627..860 CDD:455733 62/239 (26%)
leucine-rich repeat 629..652 CDD:275380 6/24 (25%)
leucine-rich repeat 653..676 CDD:275380 6/22 (27%)
leucine-rich repeat 677..700 CDD:275380 5/22 (23%)
leucine-rich repeat 701..748 CDD:275380 9/46 (20%)
leucine-rich repeat 725..736 CDD:275378 2/10 (20%)
leucine-rich repeat 749..772 CDD:275380 3/22 (14%)
leucine-rich repeat 773..793 CDD:275380 7/21 (33%)
leucine-rich repeat 821..844 CDD:275380 8/23 (35%)
leucine-rich repeat 845..868 CDD:275380 8/22 (36%)
LRR 869..1226 CDD:443914 89/406 (22%)
leucine-rich repeat 869..892 CDD:275380 6/24 (25%)
leucine-rich repeat 893..915 CDD:275380 6/22 (27%)
leucine-rich repeat 916..944 CDD:275380 8/27 (30%)
leucine-rich repeat 945..968 CDD:275380 2/22 (9%)
leucine-rich repeat 969..992 CDD:275380 6/22 (27%)
leucine-rich repeat 993..1014 CDD:275380 5/20 (25%)
leucine-rich repeat 1017..1040 CDD:275380 8/24 (33%)
leucine-rich repeat 1041..1064 CDD:275380 7/27 (26%)
leucine-rich repeat 1089..1114 CDD:275380 6/31 (19%)
leucine-rich repeat 1115..1162 CDD:275380 14/77 (18%)
PPP1R42 1155..1317 CDD:455733 28/141 (20%)
leucine-rich repeat 1163..1186 CDD:275380 2/22 (9%)
leucine-rich repeat 1187..1210 CDD:275380 3/22 (14%)
leucine-rich repeat 1211..1233 CDD:275380 8/23 (35%)
leucine-rich repeat 1234..1257 CDD:275380 3/22 (14%)
leucine-rich repeat 1258..1279 CDD:275380 2/20 (10%)
leucine-rich repeat 1282..1306 CDD:275380 5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.