DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR2 and Tl

DIOPT Version :9

Sequence 1:NP_001305716.1 Gene:TLR2 / 7097 HGNCID:11848 Length:784 Species:Homo sapiens
Sequence 2:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster


Alignment Length:879 Identity:201/879 - (22%)
Similarity:354/879 - (40%) Gaps:227/879 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    40 SGSLNSIPSGL---TEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 101
            |..|..:|.|:   ...:|.|:|.:|::..::..|.:...::..:.:..|||..:..|.|:.|.:
  Fly   206 SNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTN 270

Human   102 LEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGN--PYKTLGETSLFSHLTKLQILRVGNMDTFTK 164
            :..::||.|...:|....|.....|..:.|:.|  |..|| .:.||::..:|||||:       :
  Fly   271 VTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATL-PSRLFANQPELQILRL-------R 327

Human   165 IQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVD-VTSSVECLE 228
            .:.:...|..|....:|....|.....|:|.:      .:|..:.::|.|::..: :|...:.|.
  Fly   328 AELQSLPGDLFEHSTQITNISLGDNLLKTLPA------TLLEHQVNLLSLDLSNNRLTHLPDSLF 386

Human   229 LRDTDLDTFHFSE-LSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGV 292
            ...|:|......: |.||.:..:     |.|:    .:|..::...|::..:....|  .:.||:
  Fly   387 AHTTNLTDLRLEDNLLTGISGDI-----FSNL----GNLVTLVMSRNRLRTIDSRAF--VSTNGL 440

Human   293 GNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQ 357
            .:.....||..:....::.:...:::.|..|: :.|.||          .:.|:.:..|......
  Fly   441 RHLHLDHNDIDLQQPLLDIMLQTQINSPFGYM-HGLLTL----------NLRNNSIIFVYNDWKN 494

Human   358 HLKSLEYLDLSENLMVEEYLKNSACED-AWPSLQTLILRQNH-----LASLEKT--GETLLTLKN 414
            .:..|..||||.|     .:.:...|| |:.|...|.:...|     :|..|..  ||..  ..|
  Fly   495 TMLQLRELDLSYN-----NISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGY--NNN 552

Human   415 LTNIDISKNSFHSMPETCQ----W----------PEKMKYLNLSSTRI----------HSVTGCI 455
            |.::|::.|     |..|.    |          |:..:...|.:.|:          ..|....
  Fly   553 LVHVDLNDN-----PLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIE 612

Human   456 PKTLEI-LDVSNNN---------------------LNLFSLNLP------------QLKELYISR 486
            |:||.. ||.|::.                     :|..|.||.            ||.||::..
  Fly   613 PQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLEN 677

Human   487 NKLMTLPDASL--LPMLLVLKISRNAITTFSKEQLD--------SFHTLKTLEA----------- 530
            |.|:.||.|:.  ...:..|.::.|.:|:...:||.        |::.|:.|.|           
  Fly   678 NTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMK 742

Human   531 ------GGNNFICSC---EFLSFTQEQQALAKVLIDWPANY---------LC---DSPSHVRGQQ 574
                  .||.::|.|   ..|.|||:             |:         :|   :.|:.:    
  Fly   743 WRSVKLSGNPWMCDCTAKPLLLFTQD-------------NFERIGDRNEMMCVNAEMPTRM---- 790

Human   575 VQDVRLSVSE-CHRTALVSGMCCALFLLILLTGVLCHRFHGLWY-----MKMMWAWLQAKR---- 629
               |.||.:: |   ....|:..||.::|.|||:|......|:|     :|:   ||.|..    
  Fly   791 ---VELSTNDIC---PAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKI---WLYAHNLLLW 846

Human   630 --------KPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWII 686
                    |.:|       :|||:|||.:|..::|:.:|.:||:....|:||:|:||::.|..|.
  Fly   847 FVTEEDLDKDKK-------FDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIP 904

Human   687 DNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPI-EKKAIPQRFC 750
            :||:.|:..|.:|:.|||:||:||||.:.|...:|....:|.....|:|:...| :.:.:.:   
  Fly   905 ENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDE--- 966

Human   751 KLRKIMNTKTYLEW--PMDEAQREGFWVNLRAAI 782
            :|:..:...|||:|  |.       ||..||.|:
  Fly   967 ELKAYLKMNTYLKWGDPW-------FWDKLRFAL 993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR2NP_001305716.1 PLN00113 <40..>206 CDD:331614 39/170 (23%)
leucine-rich repeat 54..77 CDD:275380 5/22 (23%)
LRR 1 54..77 5/22 (23%)
LRR_8 77..135 CDD:316378 14/59 (24%)
leucine-rich repeat 78..101 CDD:275380 6/22 (27%)
LRR 2 78..101 6/22 (27%)
leucine-rich repeat 102..125 CDD:275380 5/22 (23%)
LRR 3 102..125 5/22 (23%)
leucine-rich repeat 126..150 CDD:275380 8/25 (32%)
LRR 4 126..150 8/25 (32%)
leucine-rich repeat 151..175 CDD:275380 6/23 (26%)
LRR 5 151..175 6/23 (26%)
LRR 6 176..199 4/22 (18%)
leucine-rich repeat 176..196 CDD:275380 4/19 (21%)
LRR 7 200..223 4/23 (17%)
LRR 8 224..250 6/26 (23%)
LRR 9 251..278 4/26 (15%)
LRR 10 279..308 5/28 (18%)
LRR 11 309..337 5/27 (19%)
NEL <324..>558 CDD:330839 68/329 (21%)
LRR 12 338..361 2/22 (9%)
leucine-rich repeat 362..388 CDD:275380 9/26 (35%)
LRR 13 362..388 9/26 (35%)
leucine-rich repeat 389..414 CDD:275380 6/31 (19%)
LRR 14 389..414 6/31 (19%)
leucine-rich repeat 415..437 CDD:275380 7/35 (20%)
LRR 15 415..437 7/35 (20%)
leucine-rich repeat 438..478 CDD:275380 13/83 (16%)
LRR 16 438..457 3/28 (11%)
LRR 17 458..478 9/53 (17%)
leucine-rich repeat 479..500 CDD:275380 8/22 (36%)
LRR 18 479..500 8/22 (36%)
leucine-rich repeat 501..524 CDD:275380 6/30 (20%)
LRR 19 501..524 6/30 (20%)
LRRCT 533..586 CDD:214507 13/68 (19%)
TIR 640..784 CDD:214587 50/146 (34%)
ATG16L1-binding motif 761..778 6/18 (33%)
TlNP_001262995.1 LRR_8 174..233 CDD:290566 8/26 (31%)
leucine-rich repeat 176..198 CDD:275380
leucine-rich repeat 199..222 CDD:275380 4/15 (27%)
LRR_RI 216..542 CDD:238064 74/366 (20%)
LRR_8 221..281 CDD:290566 14/59 (24%)
leucine-rich repeat 223..270 CDD:275380 11/46 (24%)
leucine-rich repeat 271..294 CDD:275380 5/22 (23%)
leucine-rich repeat 295..320 CDD:275380 8/25 (32%)
leucine-rich repeat 321..343 CDD:275380 7/28 (25%)
LRR_8 342..402 CDD:290566 11/65 (17%)
leucine-rich repeat 344..367 CDD:275380 5/28 (18%)
leucine-rich repeat 368..391 CDD:275380 4/22 (18%)
LRR_8 390..450 CDD:290566 13/70 (19%)
leucine-rich repeat 392..415 CDD:275380 6/31 (19%)
leucine-rich repeat 416..439 CDD:275380 3/24 (13%)
leucine-rich repeat 440..474 CDD:275380 4/34 (12%)
leucine-rich repeat 475..498 CDD:275380 5/32 (16%)
LRR_8 477..534 CDD:290566 16/71 (23%)
leucine-rich repeat 499..520 CDD:275380 9/25 (36%)
leucine-rich repeat 523..552 CDD:275380 6/30 (20%)
LRRCT 561..619 CDD:214507 11/62 (18%)
LRRNT 631..667 CDD:214470 4/35 (11%)
leucine-rich repeat 664..693 CDD:275380 9/28 (32%)
LRR_8 669..726 CDD:290566 15/56 (27%)
leucine-rich repeat 694..715 CDD:275380 5/20 (25%)
leucine-rich repeat 716..737 CDD:275380 4/20 (20%)
LRRCT 751..800 CDD:214507 14/71 (20%)
TIR 858..996 CDD:214587 51/153 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 1 1.000 - - FOG0000239
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.920

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