DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR2 and Toll-7

DIOPT Version :9

Sequence 1:NP_001305716.1 Gene:TLR2 / 7097 HGNCID:11848 Length:784 Species:Homo sapiens
Sequence 2:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster


Alignment Length:907 Identity:197/907 - (21%)
Similarity:330/907 - (36%) Gaps:295/907 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSS 118
            :..|.|:||.|:.:..:..:.|.:|:.|.|:||.:|.:.. :...|..|..|||..|.:....:.
  Fly   444 LSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPR-ALQDLAMLRTLDLGENQIRTFDNQ 507

Human   119 WFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDA 183
            .||.|..||.|.|:.|....: ...:|..|.:|.:|.:.. :....|:|..|.....||.:.:|.
  Fly   508 SFKNLHQLTGLRLIDNQIGNI-TVGMFQDLPRLSVLNLAK-NRIQSIERGSFDKNFELEAIRLDR 570

Human   184 SDLQSYEPKSLKSIQN-----VSHLILHMKQHILLLEIFVDVTSSVECL---------------- 227
            :        .|..|..     ||.|.|::.::.|:...:..:.|:::.|                
  Fly   571 N--------FLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKL 627

Human   228 --ELRDTDLDTFH-----FSELSTGET-------NSLIKKFTFRNVKITDESLFQVMKLLNQISG 278
              |:|...||..|     ...:|...|       |:||.... .|..:...:|.:|....||:| 
  Fly   628 QEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQ-PNAFVDKANLARVDLYANQLS- 690

Human   279 LLELE----------------------FD-DCT---LNGVGNFRASDNDRVIDPGKVETL----- 312
            .|:|:                      |: |||   |..:.|.....:.||:|...:|.:     
  Fly   691 KLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHAR 755

Human   313 --TIRRLH--IPRFYLFYDLSTLYSL--------------------------------------- 334
              .:|.|.  .|:.:|....|..::|                                       
  Fly   756 GAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQT 820

Human   335 TERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHL 399
            ||..:|:.:::|.|               ||| ..|..|   |||.|          .|.|:| |
  Fly   821 TELPRRVPMDSSVV---------------YLD-GNNFPV---LKNHA----------FIGRKN-L 855

Human   400 ASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDV 464
            .:|...|..:..::|.|                       :.:|:|             |::|.:
  Fly   856 RALYVNGSQVAAIQNRT-----------------------FASLAS-------------LQLLHL 884

Human   465 SNNNLNLFS----LNLPQLKELYISRNKLMTLPDASLLPM--LLVLKISRNAITTFSKEQLDSFH 523
            ::|.|....    ..|..|:|||:..|:|.|:.:|:|.|:  |.:::|..|.:.|....|:.:.|
  Fly   885 ADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATH 949

Human   524 ---TLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDV------- 578
               .||::..|.|.:.|.|:||      |||        .:|:.|:...|  |..||:       
  Fly   950 FGTRLKSISLGRNQWSCRCQFL------QAL--------TSYVADNALIV--QDAQDIYCMAASS 998

Human   579 -----RLSVSECHRTAL--------VSGMCCA---------------------------LFLLIL 603
                 .|..|..:..:|        .:|..|.                           ||||::
  Fly   999 GTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVV 1063

Human   604 LTGVLCHRFHGLWYMKMMWAWLQAKR-----KPRKAPSRNICYDAFVSYSERDAYWVENLMVQEL 663
            :..|...|       :.:..||.|..     .||...|..: |||.:.:|.:|:.:|...:..:|
  Fly  1064 IAMVFAFR-------ESLRIWLFAHYGVRVFGPRCEESEKL-YDAVLLHSAKDSEFVCQHLAAQL 1120

Human   664 ENFNPPFKLCLHKRDFIPGKWIID----NIIDSIEKSHKTVFVLSENFVKSEWCKYELDFS-HFR 723
            |...||.::||..||...     |    .::::...|.:.|.:|:.||:::||.:.||..| |..
  Fly  1121 ETGRPPLRVCLQHRDLAH-----DATHYQLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHDA 1180

Human   724 LFDENNDAAILILLEP---IEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAI 782
            |  ......::|:.||   .|.::      .:..:...||.....:..:.|. ||..||.|:
  Fly  1181 L--RGRPQKLVIIEEPEVAFEAES------DIELLPYLKTSAVHRIRRSDRH-FWEKLRYAL 1233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR2NP_001305716.1 PLN00113 <40..>206 CDD:331614 41/156 (26%)
leucine-rich repeat 54..77 CDD:275380 6/22 (27%)
LRR 1 54..77 6/22 (27%)
LRR_8 77..135 CDD:316378 19/57 (33%)
leucine-rich repeat 78..101 CDD:275380 7/22 (32%)
LRR 2 78..101 7/22 (32%)
leucine-rich repeat 102..125 CDD:275380 8/22 (36%)
LRR 3 102..125 8/22 (36%)
leucine-rich repeat 126..150 CDD:275380 7/23 (30%)
LRR 4 126..150 7/23 (30%)
leucine-rich repeat 151..175 CDD:275380 5/23 (22%)
LRR 5 151..175 5/23 (22%)
LRR 6 176..199 5/22 (23%)
leucine-rich repeat 176..196 CDD:275380 4/19 (21%)
LRR 7 200..223 5/22 (23%)
LRR 8 224..250 9/55 (16%)
LRR 9 251..278 6/26 (23%)
LRR 10 279..308 11/54 (20%)
LRR 11 309..337 8/75 (11%)
NEL <324..>558 CDD:330839 59/281 (21%)
LRR 12 338..361 3/22 (14%)
leucine-rich repeat 362..388 CDD:275380 9/25 (36%)
LRR 13 362..388 9/25 (36%)
leucine-rich repeat 389..414 CDD:275380 6/24 (25%)
LRR 14 389..414 6/24 (25%)
leucine-rich repeat 415..437 CDD:275380 1/21 (5%)
LRR 15 415..437 1/21 (5%)
leucine-rich repeat 438..478 CDD:275380 7/43 (16%)
LRR 16 438..457 2/18 (11%)
LRR 17 458..478 5/23 (22%)
leucine-rich repeat 479..500 CDD:275380 9/20 (45%)
LRR 18 479..500 9/20 (45%)
leucine-rich repeat 501..524 CDD:275380 6/25 (24%)
LRR 19 501..524 6/25 (24%)
LRRCT 533..586 CDD:214507 16/64 (25%)
TIR 640..784 CDD:214587 39/151 (26%)
ATG16L1-binding motif 761..778 3/16 (19%)
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380
LRR_RI 247..501 CDD:238064 18/57 (32%)
LRR_8 247..308 CDD:290566
leucine-rich repeat 249..273 CDD:275380
leucine-rich repeat 274..297 CDD:275380
LRR_8 297..356 CDD:290566
leucine-rich repeat 298..321 CDD:275380
leucine-rich repeat 322..345 CDD:275380
LRR_8 345..406 CDD:290566
leucine-rich repeat 346..371 CDD:275380
leucine-rich repeat 372..395 CDD:275380
leucine-rich repeat 396..419 CDD:275380
LRR_8 419..478 CDD:290566 11/33 (33%)
leucine-rich repeat 420..443 CDD:275380
leucine-rich repeat 444..467 CDD:275380 6/22 (27%)
LRR_RI 466..622 CDD:238064 39/166 (23%)
leucine-rich repeat 468..488 CDD:275380 6/20 (30%)
LRR_8 491..549 CDD:290566 17/59 (29%)
leucine-rich repeat 491..514 CDD:275380 8/22 (36%)
leucine-rich repeat 515..536 CDD:275380 6/21 (29%)
leucine-rich repeat 539..562 CDD:275380 5/23 (22%)
leucine-rich repeat 563..585 CDD:275380 5/29 (17%)
leucine-rich repeat 586..626 CDD:275380 5/39 (13%)
leucine-rich repeat 627..653 CDD:275380 6/25 (24%)
LRRCT 716..772 CDD:214507 13/55 (24%)
LRRNT 796..830 CDD:214470 3/33 (9%)
leucine-rich repeat 812..829 CDD:275380 3/16 (19%)
leucine-rich repeat 833..854 CDD:275380 12/49 (24%)
LRR_8 853..913 CDD:290566 18/96 (19%)
leucine-rich repeat 855..878 CDD:275380 6/45 (13%)
LRR_4 878..918 CDD:289563 13/52 (25%)
leucine-rich repeat 879..902 CDD:275380 5/22 (23%)
leucine-rich repeat 903..926 CDD:275380 10/22 (45%)
leucine-rich repeat 927..953 CDD:275380 6/25 (24%)
TIR 1098..1235 CDD:214587 39/150 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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