DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR2 and CG4168

DIOPT Version :10

Sequence 1:NP_003255.2 Gene:TLR2 / 7097 HGNCID:11848 Length:784 Species:Homo sapiens
Sequence 2:NP_609740.4 Gene:CG4168 / 34889 FlyBaseID:FBgn0028888 Length:1330 Species:Drosophila melanogaster


Alignment Length:752 Identity:152/752 - (20%)
Similarity:275/752 - (36%) Gaps:235/752 - (31%)


- Green bases have known domain annotations that are detailed below.


Human     7 MVWVLGV----IISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEA-----VKSLDLSNN 62
            ::| ||:    :..:|.|..:....||     ....|...|.::|.||.::     :..:|||.|
  Fly   590 LIW-LGLDNNNLKQVSNESFAQMRELS-----YINLSFNQLKTLPRGLFQSDAHSHLVEIDLSYN 648

Human    63 RITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLS----------- 116
            .:..:.........:||.|.|.||.:.||...:|.:|..|.:||||||.|.|:|           
  Fly   649 GLERLEAQTFHSLGDLQTLNLQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNISHGAFTVLPNLA 713

Human   117 ------------------------------------SSWFKPLSS-------------------- 125
                                                :|::..|||                    
  Fly   714 ALDLMHNQLCSLSLKSFLYVSNTTTPLRLNVSHNHIASFYDELSSYMYIYQLDISHNHVTKSDSF 778

Human   126 ------LTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDAS 184
                  |.||||..|...:| ::..|..|..|:||.|.: :..|.::|:.|.||..|:||::..:
  Fly   779 TNLANTLRFLNLAHNQLGSL-QSHAFGDLEFLEILNVAH-NNLTSLRRRSFQGLNSLQELDLSHN 841

Human   185 DLQSYEPKSLKSIQNVSHLILHMKQ-HILLLEIFVDVTSSVECLELRDTDLDTF---HFSELSTG 245
            .|...:.:...:::.:..|.::..: ..|..|:|::  :.:|.|::.:..|..:   .|:::.  
  Fly   842 QLDQLQVEQFSNLRKLRILRINSNRLRALPREVFMN--TRLEFLDIAENQLSVWPVPAFTDIG-- 902

Human   246 ETNSLIKKFTFRNVK--------------ITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFR 296
                    ||.|:::              |..:.|:.:....|:|:.|.:..|.  .||.:.|..
  Fly   903 --------FTLRSIQMSHNNLEYLDASMFINSQFLYDISLARNRITILPDNTFS--FLNNLTNLD 957

Human   297 ASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKS 361
            .|.|..|       |..:|.:.:.              |.|::::::.:..::::|.|   .|..
  Fly   958 LSQNPLV-------TTNLREVFVH--------------TPRLRKLSLHHMGLYVLPPL---KLPL 998

Human   362 LEYLDLSENLMVE-----------------EYLKNSAC--EDAWPSLQTLILRQNHLASLEKTGE 407
            |.|||:|.|.:.|                 ..|.|::|  |...||::.|.|..|.|..:  |..
  Fly   999 LSYLDVSGNYLQELSPLGSLRHLRHVNVSHNKLTNASCAAEHLPPSVRVLDLAHNPLRRI--TLH 1061

Human   408 TLLTLKNLTNIDI---------------SKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPK 457
            .|.:|::|..::|               |....|:...........:...|...|:|.:...|.:
  Fly  1062 DLASLRHLAELNILDVKVTNPQAFSKLRSLRKLHASSHANLGEIVARIPGLQQLRVHCLEPNIGQ 1126

Human   458 TL----------EILDVSNNNLNLFS------LNLPQLKELYISRNKLMTLPDASLLPML----L 502
            .|          .:|::..:|:...:      |:..|..::.||..::..||......:.    |
  Fly  1127 QLFAKLANNTKIRLLELYGSNVQTIAPDVFTGLSRSQRLQVKISHTRISDLPPGIFYALREVPHL 1191

Human   503 VLKISRNAITTFSKEQLDSFHTLKTL-EAGGNNFI------------CSCEFLSFTQEQQALAKV 554
            .:.||.|.|...:   .|||:..|:. :|.|...|            |.|..:.|..        
  Fly  1192 SIDISHNRINALA---ADSFYPNKSYWDAVGTRSIMGGLITSHNPLECECGLVWFGH-------- 1245

Human   555 LIDWPANYLCDSPSHVRGQQVQDV-----RLSVSECH 586
               |...:|.:| :.::..|..|:     |...:.||
  Fly  1246 ---WLRRWLRES-AQIKVIQKDDLKRMVQRARANTCH 1278

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR2NP_003255.2 LRR <39..296 CDD:443914 75/352 (21%)
leucine-rich repeat 54..77 CDD:275378 4/22 (18%)
LRR 1 54..77 4/22 (18%)
leucine-rich repeat 78..101 CDD:275378 10/22 (45%)
LRR 2 78..101 10/22 (45%)
leucine-rich repeat 102..125 CDD:275378 12/69 (17%)
LRR 3 102..125 12/69 (17%)
leucine-rich repeat 126..150 CDD:275378 9/23 (39%)
LRR 4 126..150 9/23 (39%)
LRR 5 151..175 9/23 (39%)
LRR 6 176..199 4/22 (18%)
leucine-rich repeat 176..196 CDD:275380 4/19 (21%)
LRR 7 200..223 4/23 (17%)
LRR 221..>556 CDD:443914 78/418 (19%)
LRR 8 224..250 4/28 (14%)
LRR 9 251..278 7/40 (18%)
LRR 10 279..308 8/28 (29%)
LRR 11 309..337 3/27 (11%)
LRR 12 338..361 3/22 (14%)
leucine-rich repeat 362..388 CDD:275380 11/44 (25%)
LRR 13 362..388 11/44 (25%)
leucine-rich repeat 389..414 CDD:275380 7/24 (29%)
LRR 14 389..414 7/24 (29%)
leucine-rich repeat 415..437 CDD:275380 4/36 (11%)
LRR 15 415..437 4/36 (11%)
leucine-rich repeat 438..478 CDD:275380 8/55 (15%)
LRR 16 438..457 4/18 (22%)
LRR 17 458..478 4/35 (11%)
leucine-rich repeat 479..500 CDD:275380 4/20 (20%)
LRR 18 479..500 4/20 (20%)
leucine-rich repeat 501..524 CDD:275380 8/26 (31%)
LRR 19 501..524 8/26 (31%)
LRRCT 533..586 CDD:214507 10/69 (14%)
TIR 640..784 CDD:214587
ATG16L1-binding motif 761..778
CG4168NP_609740.4 PRK15370 <69..>353 CDD:185268
leucine-rich repeat 99..118 CDD:275380
leucine-rich repeat 122..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..194 CDD:275380
leucine-rich repeat 195..214 CDD:275380
leucine-rich repeat 215..236 CDD:275380
leucine-rich repeat 266..287 CDD:275380
leucine-rich repeat 288..311 CDD:275380
leucine-rich repeat 312..338 CDD:275380
LRR <338..651 CDD:443914 16/66 (24%)
leucine-rich repeat 339..365 CDD:275380
leucine-rich repeat 366..388 CDD:275380
leucine-rich repeat 389..412 CDD:275380
leucine-rich repeat 414..436 CDD:275380
leucine-rich repeat 437..459 CDD:275380
leucine-rich repeat 460..483 CDD:275380
leucine-rich repeat 484..510 CDD:275380
leucine-rich repeat 511..534 CDD:275380
leucine-rich repeat 535..589 CDD:275380
LRR 543..971 CDD:443914 87/409 (21%)
leucine-rich repeat 590..613 CDD:275380 5/23 (22%)
leucine-rich repeat 614..639 CDD:275380 7/29 (24%)
leucine-rich repeat 640..663 CDD:275380 4/22 (18%)
leucine-rich repeat 664..687 CDD:275380 10/22 (45%)
leucine-rich repeat 688..711 CDD:275380 10/22 (45%)
leucine-rich repeat 712..735 CDD:275380 0/22 (0%)
leucine-rich repeat 740..783 CDD:275380 4/42 (10%)
leucine-rich repeat 785..808 CDD:275380 9/23 (39%)
leucine-rich repeat 809..832 CDD:275380 9/23 (39%)
leucine-rich repeat 833..856 CDD:275380 4/22 (18%)
leucine-rich repeat 857..879 CDD:275380 4/23 (17%)
leucine-rich repeat 880..900 CDD:275380 4/19 (21%)
leucine-rich repeat 905..928 CDD:275380 2/22 (9%)
LRR 911..>1203 CDD:443914 61/319 (19%)
leucine-rich repeat 929..952 CDD:275380 6/24 (25%)
leucine-rich repeat 953..977 CDD:275380 7/44 (16%)
leucine-rich repeat 978..1020 CDD:275380 10/44 (23%)
leucine-rich repeat 1045..1068 CDD:275380 7/24 (29%)
leucine-rich repeat 1069..1090 CDD:275380 2/20 (10%)
leucine-rich repeat 1091..1114 CDD:275380 2/22 (9%)
leucine-rich repeat 1115..1161 CDD:275380 7/45 (16%)
leucine-rich repeat 1162..1190 CDD:275380 5/27 (19%)
PCC 1230..>1298 CDD:188093 11/61 (18%)
Blue background indicates that the domain is not in the aligned region.

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