| Sequence 1: | NP_003254.2 | Gene: | TLR1 / 7096 | HGNCID: | 11847 | Length: | 786 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001263151.1 | Gene: | kek6 / 43729 | FlyBaseID: | FBgn0039862 | Length: | 843 | Species: | Drosophila melanogaster |
| Alignment Length: | 341 | Identity: | 76/341 - (22%) |
|---|---|---|---|
| Similarity: | 122/341 - (35%) | Gaps: | 108/341 - (31%) |
- Green bases have known domain annotations that are detailed below.
|
Human 36 LIHVPKDLSQKTTILNISQNYI-----SELWTSDILSLSK------------------LRILI-- 75
Human 76 -ISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHL------DLSFNAFDALPICK 133
Human 134 EFGNMSQLKFLGLSTTHLEKSSVLPIAHL-----------------------------NISKVLL 169
Human 170 VL-------GETYGEKED-----PEGLQDFNTESL-HIVFPTNKEFHFILDVSVKTVANLELSNI 221
Human 222 KCVLEDNKCSYFLSILAKLQTNPKL-SNLTLNNIET-----------------TWNSFIRILQLV 268
Human 269 WHT------TVWYFSI 278 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| TLR1 | NP_003254.2 | LRR | <29..>152 | CDD:443914 | 35/147 (24%) |
| leucine-rich repeat | 47..70 | CDD:275378 | 7/27 (26%) | ||
| LRR 1 | 54..77 | 9/48 (19%) | |||
| leucine-rich repeat | 71..94 | CDD:275378 | 9/25 (36%) | ||
| LRR 2 | 78..101 | 7/22 (32%) | |||
| leucine-rich repeat | 95..115 | CDD:275378 | 5/19 (26%) | ||
| LRR 3 | 102..125 | 6/28 (21%) | |||
| leucine-rich repeat | 116..140 | CDD:275378 | 6/29 (21%) | ||
| LRR 4 | 126..150 | 6/23 (26%) | |||
| leucine-rich repeat | 141..152 | CDD:275378 | 4/10 (40%) | ||
| LRR 5 | 151..175 | 8/59 (14%) | |||
| LRR 6 | 176..199 | 6/28 (21%) | |||
| LRR 7 | 200..223 | 4/22 (18%) | |||
| LRR | 215..>526 | CDD:443914 | 24/88 (27%) | ||
| LRR 8 | 224..250 | 8/26 (31%) | |||
| LRR 9 | 251..278 | 10/49 (20%) | |||
| LRR 10 | 279..308 | 76/341 (22%) | |||
| LRR 11 | 309..337 | ||||
| Interaction with bacterial lipopeptide | 313..316 | ||||
| LRR 12 | 338..361 | ||||
| leucine-rich repeat | 352..373 | CDD:275380 | |||
| LRR 13 | 362..388 | ||||
| leucine-rich repeat | 374..399 | CDD:275380 | |||
| LRR 14 | 389..414 | ||||
| leucine-rich repeat | 400..424 | CDD:275380 | |||
| LRR 15 | 415..437 | ||||
| leucine-rich repeat | 425..446 | CDD:275380 | |||
| LRR 16 | 438..457 | ||||
| leucine-rich repeat | 447..469 | CDD:275380 | |||
| LRR 17 | 458..478 | ||||
| leucine-rich repeat | 470..492 | CDD:275380 | |||
| LRR 18 | 479..500 | ||||
| leucine-rich repeat | 494..515 | CDD:275380 | |||
| LRR 19 | 501..524 | ||||
| LRRCT | 524..577 | CDD:214507 | |||
| TIR | 636..779 | CDD:214587 | |||
| kek6 | NP_001263151.1 | LRR | <56..>226 | CDD:443914 | 39/169 (23%) |
| leucine-rich repeat | 71..96 | CDD:275380 | 5/24 (21%) | ||
| LRR_8 | 96..155 | CDD:404697 | 14/58 (24%) | ||
| leucine-rich repeat | 97..120 | CDD:275380 | 2/22 (9%) | ||
| leucine-rich repeat | 121..144 | CDD:275380 | 7/22 (32%) | ||
| leucine-rich repeat | 145..168 | CDD:275380 | 6/22 (27%) | ||
| leucine-rich repeat | 169..216 | CDD:275380 | 12/50 (24%) | ||
| LRRCT | 225..274 | CDD:214507 | 6/48 (13%) | ||
| Ig | 286..360 | CDD:472250 | 18/79 (23%) | ||
| Ig strand B | 294..298 | CDD:409353 | 1/3 (33%) | ||
| Ig strand C | 307..310 | CDD:409353 | 0/2 (0%) | ||
| Ig strand E | 336..340 | CDD:409353 | 3/3 (100%) | ||
| Ig strand F | 350..355 | CDD:409353 | 0/4 (0%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||