DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR1 and MstProx

DIOPT Version :10

Sequence 1:NP_003254.2 Gene:TLR1 / 7096 HGNCID:11847 Length:786 Species:Homo sapiens
Sequence 2:NP_649719.2 Gene:MstProx / 40890 FlyBaseID:FBgn0015770 Length:965 Species:Drosophila melanogaster


Alignment Length:813 Identity:179/813 - (22%)
Similarity:305/813 - (37%) Gaps:223/813 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    19 IQLSEESEFLVDRSKNGLIHVP--KDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRI 81
            :.:.::.|..:|.|..||:.:|  ...|.....||.|.|.:|:|.|..:.....::.|.:|.||:
  Fly   292 LYIIDDLELNIDCSNLGLLQIPPLPIPSYGGVKLNFSNNSLSQLPTMTLPGYKLVKRLDVSRNRL 356

Human    82 QYLDISVFKFNQELEYLDLSHNKLVKISCHPTVN--LKHLDLSFNAFDALPICKEFGNMSQLKFL 144
              .::|:.....:|:|||:|.|:::.:.     |  :|:|       ..:||.|:.||.      
  Fly   357 --TNLSINHLPAKLDYLDVSFNEIINMG-----NDVIKYL-------RTVPIFKQTGNQ------ 401

Human   145 GLSTTHLEKSSVLP-IAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEF------ 202
              .|.|.:...:|. ..||   |:::.:...           :.....||.:....|.|      
  Fly   402 --WTIHCDDKPLLNFFRHL---KLIIRMKSA-----------EMKPMFLHSLTELPKGFLKFLGK 450

Human   203 HFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNL--TLNNIETTWNSFIRIL 265
            |||.                  |...|..|:|     :.....|.::  .|||:.|        :
  Fly   451 HFIW------------------LGVRKQEYYL-----INEEQLLQSMHRKLNNLNT--------I 484

Human   266 QLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKN 330
            ..::....|        |..:|.|.:.:|               |:|     ||           
  Fly   485 MSIYKYMEW--------LHRKLIFVNREY---------------DLF-----YI----------- 510

Human   331 FTVSGTRMVHMLCP-------SKISPFLHLDFSNNLL---TDTVFENCGHLTELETLILQMNQLK 385
                  |.:...||       |:.|..|.:|..|..:   .|.|..| ..|...:.:...|....
  Fly   511 ------RQMAAPCPHKCECCYSRDSLILKIDCRNKFVYNFPDIVARN-SRLMGKQNMSSPMELHL 568

Human   386 ELSKIAEMTTQM--KSLQQLDIS-QNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRI 447
            ..:.|:.:|..|  |.|:.||:. .|.|:.|:|      ..|.|..|.....|:...:.|     
  Fly   569 SKNNISNITIAMLPKELRFLDLRFNNLVTLDDK------VLSYLKKNSIKTKLSGNPWNC----- 622

Human   448 KVLDLHSNKIKSIPKQVVKLE---ALQELNVAFNSLTDLP----------------------GCG 487
               |..|..:.||.:....||   .|:..|:   |.||.|                      |..
  Fly   623 ---DCKSRSVLSILRDHEPLEYDVTLKRCNI---SPTDCPDVCVCCLDNLTWPSFIVDCRGEGLL 681

Human   488 SFSSLS--VLIID--HNSVSHPSADFFQSCQKMRSIKAG--DNPFQCTCELGEFVKNIDQVSSEV 546
            ...|||  |..:|  :|:::..|.....|.:. ||:|..  |||:.|:|...|.:..:..|||.:
  Fly   682 QMPSLSSRVTYVDLRNNNLTALSQKNRSSIEN-RSLKLHLLDNPWSCSCNDIEKINFMKSVSSSI 745

Human   547 LEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITL-----LIVTIVATMLVLAVTVTSLCSYLDL 606
            ::.  ...||.     .|..|...: ..:.|...|     |.:::|||::.|...:         
  Fly   746 VDF--TEIKCS-----NGEKLVSIN-QHIVCPSDLFYYLALAISLVATIIALNFLI--------- 793

Human   607 PWYLRMVCQWTQTRRRARNIPLE-ELQRNLQFHAFISYSGHDSFWVKNELLPNLE--KEGMQICL 668
             |:.:.|..|........::..: ||.::.:|.||::::..|...:: |.:..||  :...|:|.
  Fly   794 -WFRQPVLVWFYEHGVCLSLSAKRELDKDKRFDAFLAFTHKDEALLE-EFVDRLERGRPRFQLCF 856

Human   669 HERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEP 733
            :.|:::.|:||.:.|...|:.|.:.|.:::.||:.|.|...|...|.|....:....||::|...
  Fly   857 YLRDWLAGESIPDCIGQSIKDSRRIIVLMTENFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPN 921

Human   734 IPQYSIPSSYHKLKSLMARRTYLE------WPK 760
            :..:....|  :|::.||..||||      |.|
  Fly   922 VKNFDSLDS--ELRTYMAFNTYLERSHPNFWNK 952

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR1NP_003254.2 LRR <29..>152 CDD:443914 34/126 (27%)
leucine-rich repeat 47..70 CDD:275378 7/22 (32%)
LRR 1 54..77 5/22 (23%)
leucine-rich repeat 71..94 CDD:275378 5/22 (23%)
LRR 2 78..101 7/22 (32%)
leucine-rich repeat 95..115 CDD:275378 6/19 (32%)
LRR 3 102..125 4/24 (17%)
leucine-rich repeat 116..140 CDD:275378 7/23 (30%)
LRR 4 126..150 6/23 (26%)
leucine-rich repeat 141..152 CDD:275378 2/10 (20%)
LRR 5 151..175 4/24 (17%)
LRR 6 176..199 2/22 (9%)
LRR 7 200..223 5/28 (18%)
LRR 215..>526 CDD:443914 73/356 (21%)
LRR 8 224..250 5/27 (19%)
LRR 9 251..278 5/26 (19%)
LRR 10 279..308 4/28 (14%)
LRR 11 309..337 4/27 (15%)
Interaction with bacterial lipopeptide 313..316 0/2 (0%)
LRR 12 338..361 7/32 (22%)
leucine-rich repeat 352..373 CDD:275380 6/23 (26%)
LRR 13 362..388 5/25 (20%)
leucine-rich repeat 374..399 CDD:275380 4/26 (15%)
LRR 14 389..414 9/27 (33%)
leucine-rich repeat 400..424 CDD:275380 7/24 (29%)
LRR 15 415..437 5/21 (24%)
leucine-rich repeat 425..446 CDD:275380 4/20 (20%)
LRR 16 438..457 3/18 (17%)
leucine-rich repeat 447..469 CDD:275380 6/24 (25%)
LRR 17 458..478 6/22 (27%)
leucine-rich repeat 470..492 CDD:275380 7/43 (16%)
LRR 18 479..500 10/46 (22%)
leucine-rich repeat 494..515 CDD:275380 5/22 (23%)
LRR 19 501..524 5/24 (21%)
LRRCT 524..577 CDD:214507 12/52 (23%)
TIR 636..779 CDD:214587 37/133 (28%)
MstProxNP_649719.2 PRK15370 <315..>398 CDD:185268 25/96 (26%)
leucine-rich repeat 325..345 CDD:275378 7/19 (37%)
leucine-rich repeat 346..367 CDD:275378 5/22 (23%)
TIR 823..960 CDD:214587 37/133 (28%)

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