Protein Alignment TLR1 and Toll-9

DIOPT Version :10

• Sequence 1: NP_003254.2
• Gene: TLR1 / 7096
• HGNCID: 11847
• Length: 786
• Species: Homo sapiens
• Sequence 2: NP_649214.1
• Gene: Toll-9 / 40245
• FlyBaseID: FBgn0036978
• Length: 900
• Species: Drosophila melanogaster
• Alignment Length: 945
• Identity: 212/945 - (22%)
• Similarity: 361/945 - (38%)
• Gaps: 270/945 - (28%)

Human    25 SEFLVDRSKNGLIHVPKDLS-----------QKTTILNISQNYISELWTSDILSLSKLRILIISH 78
            :||.:   ::|||..|...:           ::|.:.::...|.|:...|.:|.|.|..::....
  Fly    25 TEFSI---QDGLIIEPDSATTSSEEAEEVSKERTDLKSLMLKYESDDGNSCLLDLIKDEVIWWQF 86

Human    79 NRIQYLDISVFKFNQELEYLDLSHNKL---------VKISCHPTV-NLKHLDLSFNAFDALPICK 133
            ......| |..|:..:| ||||||..|         .|:|...|: ..:....:||...|.|...
  Fly    87 PNGTLRD-STKKYAHKL-YLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRT 149

Human   134 EFGNMSQLKFLGL-------------------STTHLEKSSVLPIAHLNISKVLLVLGETYGEKE 179
            .:.....||.|.|                   :.:.||.|:.:| .|..    ||:|..|
  Fly   150 LYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVP-HHCE----LLLLHNT----- 204

Human   180 DPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLS----ILAKL 240
                 .|......::.|..|..    :..|:.|..|  .:|...||:|....:..|    ..|..
  Fly   205 -----TDLYDRECYLYFNNNTN----MGQSITTGRN--YTNFIKVLKDRFDQHGSSSQSIAWATF 258

Human   241 QTNPKLSNLTLNNIETTW---NSFIRILQL------------VWHTTVWYFSISNVKLQG----Q 286
            ...|:|..|.::|....:   .:|..:..|            :.|.|.:|       :||    .
  Fly   259 PKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYY-------VQGVQYLD 316

Human   287 LDFRDFDYSGTSLKALSIHQVVSDVFG----------FPQSYIYEIFSNMNIKNFTVS----GTR 337
            |.|.:|......|:..::...:|.::|          .|:....::..:...:|..|:    |.:
  Fly   317 LSFTNFLTYSYQLQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAHLGDK 381

Human   338 MVHM-LCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQM-KSL 400
            :..: ||.:.|.          :::.|:|:|    |.||.|.|..|.....:.|.:....: .:|
  Fly   382 LKFLSLCYTAIP----------MVSSTIFKN----TVLEGLDLSGNPYLSYNIIDDAFDGIANTL 432

Human   401 QQLDISQNSVSYDEKKGDCSWTKSLLSLNM------SSNILTDTIFRCLPPRIKVLDLHSNKIKS 459
            :.|...::::.      |..|:|||.:|.:      :.|.||..:|:.| ..:::|||.||.:.:
  Fly   433 KYLYFERSNIK------DLEWSKSLKNLQVLGLAGNNINALTPAMFQSL-ESLEILDLSSNHVGN 490

Human   460 IPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDN 524
            ..:.            ||:         :.|:|.||.:..|:::..|.:..:..:::..:..|||
  Fly   491 WYRS------------AFH---------NNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDN 534

Human   525 PFQCTCELGEFVK----------------NIDQ--VSSEVL----------EGWPDSY------- 554
            .|.|.|.|...|:                |..|  |..||:          :.|...|
  Fly   535 DFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRS 599

Human   555 --------------------------KCDYPESYR-----GTL-----LKDFHMS---------- 573
                                      ||...:.|.     |.|     |.|:..|
  Fly   600 YSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQ 664

Human   574 ----ELSCNITLL----------IVTIVATM-LVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRA 623
                ||:|.|..:          ..|::|.| .::...:.....||. .|::.......::....
  Fly   665 LQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLK-RWHIHYYYSSLKSAALL 728

Human   624 RNIPLEELQR--NLQ-------FHAFISYSGHDSFWVKNELLPNLEKEG-MQICLHERNFVPGKS 678
            .:...|.:.:  |:.       :..||||..:|..||.||||||:|:.| :.||||||:|..|.:
  Fly   729 SSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETGDVSICLHERDFQIGVT 793

Human   679 IVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSY 743
            |::|||:|:::||..:.::|..|:.|.||.:|:|.|.|.:|......|||:.||.||:...|.:
  Fly   794 ILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRPKT- 857

Human   744 HKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINI 778
              |:.||..:||::||..|..|.|||..|:.::.:
  Fly   858 --LQYLMDVKTYIKWPTAKEDRKLFWKRLKRSLEV 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TLR1	NP_003254.2	LRR	<29..>152	CDD:443914	33/162 (20%)
		leucine-rich repeat	47..70	CDD:275378	6/22 (27%)
		LRR 1	54..77		6/22 (27%)
		leucine-rich repeat	71..94	CDD:275378	3/22 (14%)
		LRR 2	78..101		7/22 (32%)
		leucine-rich repeat	95..115	CDD:275378	11/29 (38%)
		LRR 3	102..125		6/32 (19%)
		leucine-rich repeat	116..140	CDD:275378	4/23 (17%)
		LRR 4	126..150		6/42 (14%)
		leucine-rich repeat	141..152	CDD:275378	4/29 (14%)
		LRR 5	151..175		8/23 (35%)
		LRR 6	176..199		2/22 (9%)
		LRR 7	200..223		4/22 (18%)
		LRR	215..>526	CDD:443914	70/355 (20%)
		LRR 8	224..250		7/29 (24%)
		LRR 9	251..278		6/41 (15%)
		LRR 10	279..308		6/32 (19%)
		LRR 11	309..337		6/41 (15%)
		Interaction with bacterial lipopeptide	313..316		1/12 (8%)
		LRR 12	338..361		3/23 (13%)
		leucine-rich repeat	352..373	CDD:275380	3/20 (15%)
		LRR 13	362..388		9/25 (36%)
		leucine-rich repeat	374..399	CDD:275380	6/25 (24%)
		LRR 14	389..414		3/25 (12%)
		leucine-rich repeat	400..424	CDD:275380	4/23 (17%)
		LRR 15	415..437		8/27 (30%)
		leucine-rich repeat	425..446	CDD:275380	7/26 (27%)
		LRR 16	438..457		7/18 (39%)
		leucine-rich repeat	447..469	CDD:275380	5/21 (24%)
		LRR 17	458..478		1/19 (5%)
		leucine-rich repeat	470..492	CDD:275380	3/21 (14%)
		LRR 18	479..500		4/20 (20%)
		leucine-rich repeat	494..515	CDD:275380	4/20 (20%)
		LRR 19	501..524		2/22 (9%)
		LRRCT	524..577	CDD:214507	23/137 (17%)
		TIR	636..779	CDD:214587	61/151 (40%)
Toll-9	NP_649214.1	LRR	198..537	CDD:443914	79/403 (20%)
		leucine-rich repeat	264..287	CDD:275380	4/22 (18%)
		leucine-rich repeat	288..311	CDD:275380	4/29 (14%)
		leucine-rich repeat	312..356	CDD:275380	6/43 (14%)
		leucine-rich repeat	357..381	CDD:275380	3/23 (13%)
		leucine-rich repeat	382..397	CDD:275380	3/24 (13%)
		leucine-rich repeat	405..430	CDD:275380	6/24 (25%)
		leucine-rich repeat	432..453	CDD:275380	7/26 (27%)
		leucine-rich repeat	454..477	CDD:275380	6/23 (26%)
		leucine-rich repeat	478..501	CDD:275380	7/43 (16%)
		leucine-rich repeat	502..525	CDD:275380	5/22 (23%)
		TIR	751..891	CDD:214587	61/143 (43%)