DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR1 and Toll-6

DIOPT Version :10

Sequence 1:NP_003254.2 Gene:TLR1 / 7096 HGNCID:11847 Length:786 Species:Homo sapiens
Sequence 2:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster


Alignment Length:966 Identity:208/966 - (21%)
Similarity:351/966 - (36%) Gaps:267/966 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    28 LVDRSKNGLIHVPKDL--------------SQKTTILN--------------ISQNYISELW--T 62
            :::.|.|.::.:|.:|              :...::||              :|.|.|:..|  .
  Fly   329 ILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDK 393

Human    63 SDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCH---PTVNLKHLDLSFN 124
            :..:.|.:|.:|.:|||::..|:..:|.....|:.|:|.||:|..|:..   |..||..|.||.|
  Fly   394 NTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHN 458

Human   125 --------AFDALPICK---------------EFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISK 166
                    |.:.|.:..               .|.|.|.|:.|.|:...|:   .:|:|..|:..
  Fly   459 KLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLK---TVPLALRNMRH 520

Human   167 VLLV-LGE---TYGEKEDPEGLQDFNTESLHIV--FPTNKEFHFILDVSVKTVANLELSNIKCVL 225
            :..| |||   |..|....:||.  |...|.::  :..|...|...|:....:.||..:.| .|:
  Fly   521 LRTVDLGENMITVMEDSAFKGLG--NLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRI-AVV 582

Human   226 EDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFR 290
            |........||.|     .:|....||:|.   ..|..:..|:|      .:||:.:|:      
  Fly   583 EPGAFEMTSSIQA-----VRLDGNELNDIN---GLFSNMPSLLW------LNISDNRLE------ 627

Human   291 DFDYS--GTSLKALSIHQ----VVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISP 349
            .|||.  .::|:.|.:|:    .:|:.||        :.|.:.::...||..:: ..:.||.|..
  Fly   628 SFDYGHVPSTLQWLDLHKNRLSSLSNRFG--------LDSELKLQTLDVSFNQL-QRIGPSSIPN 683

Human   350 FLHLDFSN-NLLTDTVFENCGHLTELETLILQMNQLKE--------------------------- 386
            .:.|.|.| ||:|....:...|.|.|..:.|..||:..                           
  Fly   684 SIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPF 748

Human   387 --------LSKIAEMTT-QMKSLQQLD------ISQNSVSY-----DEKKG-------------- 417
                    |.||..:|: |...:..|:      ::....:|     .|.|.              
  Fly   749 TCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCH 813

Human   418 -------DC--------------SWTKSLLSLN-------------------------------- 429
                   ||              :|:.:::..:                                
  Fly   814 CCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHS 878

Human   430 ------------MSSNI--LTDTIFRCLPPRIKVLDLHSNKIKSIP-KQVVKLEALQELNVAFNS 479
                        .:||:  :.:|.|..| .|:.:|.|..|.|.|:. .:...||.|:||.:..|.
  Fly   879 FLGRKNLAVLYANNSNVAHIYNTTFSGL-KRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNK 942

Human   480 LTDLPGCGSFS---SLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTC-ELGEFVKNID 540
            :..:.. |||.   .|.||.:|.|.:.|.......:...:..|...||.:.|.| .|..|...:.
  Fly   943 IASIAN-GSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLG 1006

Human   541 QVSSEVLEGWPDSYKCDYPES------YRGT--LLKD-----FHMSELSCNITLLIVTIVATMLV 592
            |.|.::::.  ....|.|..:      ..||  .|:|     .|.:|:...:.||:|...|.:..
  Fly  1007 QSSEKIIDA--SRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAF 1069

Human   593 LAVTVTSLCSYLDLP-WYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELL 656
            ..:.....|...:|. |.....|......:..|.:  ::|.:.....|:.:||..|..:|...|.
  Fly  1070 FGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFV--DQLDKERPNDAYFAYSLQDEHFVNQILA 1132

Human   657 PNLEKE-GMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFH 720
            ..||.: |.::|||.|:......|.:.:|...|.:.:.:.|||.||:.:||..:|...|.|.|. 
  Fly  1133 QTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELV- 1196

Human   721 EGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAI 776
            :....::.||...:||..|...   ::..:...|.:||..:|     ||..||.|:
  Fly  1197 KRRKRVVFILYGDLPQRDIDMD---MRHYLRTSTCIEWDDKK-----FWQKLRLAL 1244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR1NP_003254.2 LRR <29..>152 CDD:443914 40/178 (22%)
leucine-rich repeat 47..70 CDD:275378 7/38 (18%)
LRR 1 54..77 6/24 (25%)
leucine-rich repeat 71..94 CDD:275378 7/22 (32%)
LRR 2 78..101 6/22 (27%)
leucine-rich repeat 95..115 CDD:275378 8/22 (36%)
LRR 3 102..125 11/33 (33%)
leucine-rich repeat 116..140 CDD:275378 9/46 (20%)
LRR 4 126..150 7/38 (18%)
leucine-rich repeat 141..152 CDD:275378 3/10 (30%)
LRR 5 151..175 8/27 (30%)
LRR 6 176..199 5/24 (21%)
LRR 7 200..223 5/22 (23%)
LRR 215..>526 CDD:443914 86/449 (19%)
LRR 8 224..250 6/25 (24%)
LRR 9 251..278 6/26 (23%)
LRR 10 279..308 8/34 (24%)
LRR 11 309..337 6/27 (22%)
Interaction with bacterial lipopeptide 313..316 1/2 (50%)
LRR 12 338..361 8/23 (35%)
leucine-rich repeat 352..373 CDD:275380 7/21 (33%)
LRR 13 362..388 6/60 (10%)
leucine-rich repeat 374..399 CDD:275380 9/60 (15%)
LRR 14 389..414 6/36 (17%)
leucine-rich repeat 400..424 CDD:275380 7/69 (10%)
LRR 15 415..437 6/102 (6%)
leucine-rich repeat 425..446 CDD:275380 5/66 (8%)
LRR 16 438..457 7/18 (39%)
leucine-rich repeat 447..469 CDD:275380 6/22 (27%)
LRR 17 458..478 6/20 (30%)
leucine-rich repeat 470..492 CDD:275380 7/24 (29%)
LRR 18 479..500 7/23 (30%)
leucine-rich repeat 494..515 CDD:275380 5/20 (25%)
LRR 19 501..524 2/22 (9%)
LRRCT 524..577 CDD:214507 15/66 (23%)
TIR 636..779 CDD:214587 41/142 (29%)
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733
leucine-rich repeat 148..171 CDD:275380
leucine-rich repeat 172..201 CDD:275380
LRR_8 200..>246 CDD:404697
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
leucine-rich repeat 279..302 CDD:275380
LRR 299..654 CDD:443914 82/350 (23%)
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380 4/20 (20%)
leucine-rich repeat 352..375 CDD:275380 2/22 (9%)
leucine-rich repeat 376..401 CDD:275380 5/24 (21%)
leucine-rich repeat 402..425 CDD:275380 7/22 (32%)
leucine-rich repeat 426..449 CDD:275380 8/22 (36%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 2/22 (9%)
leucine-rich repeat 498..518 CDD:275380 6/22 (27%)
leucine-rich repeat 521..544 CDD:275380 8/24 (33%)
leucine-rich repeat 545..566 CDD:275380 3/20 (15%)
leucine-rich repeat 569..592 CDD:275380 5/23 (22%)
leucine-rich repeat 593..615 CDD:275380 7/29 (24%)
leucine-rich repeat 616..637 CDD:275380 8/32 (25%)
leucine-rich repeat 638..662 CDD:275380 7/31 (23%)
LRR_8 662..719 CDD:404697 16/57 (28%)
leucine-rich repeat 663..684 CDD:275380 5/21 (24%)
leucine-rich repeat 685..708 CDD:275380 7/22 (32%)
leucine-rich repeat 709..728 CDD:275380 4/18 (22%)
LRR <863..>990 CDD:443914 28/128 (22%)
leucine-rich repeat 885..908 CDD:275380 5/23 (22%)
leucine-rich repeat 909..932 CDD:275380 6/22 (27%)
leucine-rich repeat 933..956 CDD:275380 7/23 (30%)
TIR 1114..1247 CDD:214587 41/140 (29%)
Blue background indicates that the domain is not in the aligned region.

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