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Protein Alignment TLR1 and CG4168

DIOPT Version :10

Sequence 1:	NP_003254.2	Gene:	TLR1 / 7096	HGNCID:	11847	Length:	786	Species:	Homo sapiens
Sequence 2:	NP_609740.4	Gene:	CG4168 / 34889	FlyBaseID:	FBgn0028888	Length:	1330	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	194/992 - (19%)
Similarity:	343/992 - (34%)	Gaps:	326/992 - (32%)

- Green bases have known domain annotations that are detailed below.

Human     2 TSIFHFAIIFMLILQIRIQ----LSEESEFLVDRSKNGLIHVPKDLS--QKTTILNISQNYISEL 60
            |.|.|..:.|..|.::...    |:|..|:| |..:|.|..||..||  .....|.::.|.||:|
  Fly   387 TGIAHLVLAFNAISRVHPSAFEGLTETLEYL-DLERNRLTTVPVALSSLHHLKYLYLTSNQISQL 450

Human    61 -----WTSD--ILSL-------------------------------------------SKLRILI 75
                 :|.:  :|||                                           |.|:.::
  Fly   451 NNLPSFTENLRVLSLSGNNFSMIPVLGLKNYTQLSYLNMGYNSITDIPEGIFAVDSWGSNLQTIL 515

Human    76 ISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTV------NLKHLDLSFNAFDA------ 128
            :.:|:|.:|.:..|...::::.:.||.|.:.  ..||.|      .||.|:|||..|.|
  Fly   516 LRNNKITHLHLGSFAGLEQIQEISLSFNDIT--IHHPLVFENVSRTLKILELSFAVFPARSLESL 578

Human   129 ------LPICKEFGNMSQLKFLGLSTTHLEKSS------VLPIAHLNIS---------------- 165
                  ||       :|||.:|||...:|::.|      :..::::|:|
  Fly   579 DPLDALLP-------LSQLIWLGLDNNNLKQVSNESFAQMRELSYINLSFNQLKTLPRGLFQSDA 636

Human   166 -KVLLVLGETYGEKEDPEG--------LQDFNTESLHIVFPTNKEFHFI-----LDVSVKTVANL 216
             ..|:.:..:|...|..|.        ||..|.:|..:.......||.:     ||:|...:.|:
  Fly   637 HSHLVEIDLSYNGLERLEAQTFHSLGDLQTLNLQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNI 701

Human   217 E------LSNIKC--VLEDNKCSYFLS--ILAKLQTNPKLSNLTLNNIETTW---NSFIRILQL- 267
            .      |.|:..  ::.:..||..|.  :.....|.|...|::.|:|.:.:   :|::.|.||
  Fly   702 SHGAFTVLPNLAALDLMHNQLCSLSLKSFLYVSNTTTPLRLNVSHNHIASFYDELSSYMYIYQLD 766

Human   268 VWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFT 332
            :.|..|.. |.|...|...|.|.:..::  .|.:|..|     .||     ..|....:|:.:..
  Fly   767 ISHNHVTK-SDSFTNLANTLRFLNLAHN--QLGSLQSH-----AFG-----DLEFLEILNVAHNN 818

Human   333 VSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQM 397
            ::..|....   ..::....||.|:|.|.....|...:|.:|..|.:..|:|:.|.:...|.|::
  Fly   819 LTSLRRRSF---QGLNSLQELDLSHNQLDQLQVEQFSNLRKLRILRINSNRLRALPREVFMNTRL 880

Human   398 K----------------------SLQQLDISQNSVSYDEKK-----------------------G 417
            :                      :|:.:.:|.|::.|.:..                       .
  Fly   881 EFLDIAENQLSVWPVPAFTDIGFTLRSIQMSHNNLEYLDASMFINSQFLYDISLARNRITILPDN 945

Human   418 DCSWTKSLLSLNMSSNILTDTIFRCL---PPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNS 479
            ..|:..:|.:|::|.|.|..|..|.:   .||::.|.||...:..:|.  :||..|..|:|:.|.
  Fly   946 TFSFLNNLTNLDLSQNPLVTTNLREVFVHTPRLRKLSLHHMGLYVLPP--LKLPLLSYLDVSGNY 1008

Human   480 LTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSS 544
            |.:|...||...|..:.:.||.:::.|.........:|.:....||.
  Fly  1009 LQELSPLGSLRHLRHVNVSHNKLTNASCAAEHLPPSVRVLDLAHNPL------------------ 1055

Human   545 EVLEGWPDSYKCDYPESYRGTLLKDF----HMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLD 605
                              |...|.|.    |::||:               :|.|.||:..::..
  Fly  1056 ------------------RRITLHDLASLRHLAELN---------------ILDVKVTNPQAFSK 1087

Human   606 LPWYLRMVCQWTQTRRRARNIPLEEL------QRNLQFHAFISYSGHDSF--WVKNELLPNLEKE 662
            |....::        ..:.:..|.|:      .:.|:.|......|...|  ...|..:..||..
  Fly  1088 LRSLRKL--------HASSHANLGEIVARIPGLQQLRVHCLEPNIGQQLFAKLANNTKIRLLELY 1144

Human   663 GMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLI 727
            |..:          ::|..::.|.:.:|.:         :|.:..|..:......:|:
  Fly  1145 GSNV----------QTIAPDVFTGLSRSQR---------LQVKISHTRISDLPPGIFY------- 1183

Human   728 LILLEPIPQYSIPSSYHKLKSLMARRTYLE---W-----------------PKEKSKRGLFWAN- 771
              .|..:|..||..|::::.:|.|...|..   |                 |.| .:.||.|..
  Fly  1184 --ALREVPHLSIDISHNRINALAADSFYPNKSYWDAVGTRSIMGGLITSHNPLE-CECGLVWFGH 1245

Human   772 -----LRAAINIKLTEQ 783
                 ||.:..||:.::
  Fly  1246 WLRRWLRESAQIKVIQK 1262

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.