| Sequence 1: | NP_003254.2 | Gene: | TLR1 / 7096 | HGNCID: | 11847 | Length: | 786 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_523519.2 | Gene: | Toll-4 / 34235 | FlyBaseID: | FBgn0032095 | Length: | 1125 | Species: | Drosophila melanogaster |
| Alignment Length: | 843 | Identity: | 167/843 - (19%) |
|---|---|---|---|
| Similarity: | 322/843 - (38%) | Gaps: | 227/843 - (26%) |
- Green bases have known domain annotations that are detailed below.
|
Human 23 EESEFLVDRSKNGL-----IHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQ 82
Human 83 YLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQL------ 141
Human 142 ---------KFLGLSTTHLEKSSVLPIAHLNISKVLLV-------LGETYGEKEDPEGLQDFNTE 190
Human 191 SLHIVFPTNKEFHFILDVSVKTVANL---ELSNIKCVLEDNKCSYFLSILAKLQTNPKL---SNL 249
Human 250 TLNNIETTWNSFIRILQLVWHTTVWYFSISNVK---------LQGQLDFRDFDYSGTSLKALSIH 305
Human 306 QVVSDVFGFPQSYIY-EIFSNM----------------NIKNFTVSGTRMVHMLCPSKISPFLH- 352
Human 353 ------LDFSNNL----LTDTVFEN----CGHLTELETLILQMN-QLKELSKIAEMTTQMKSLQQ 402
Human 403 LDISQNSVSYDEKKGDCSWTKSLL-------SLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSI 460
Human 461 PKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRS----IKA 521
Human 522 GDNPFQCTCELGEFV-------KNIDQVSSEVLEGWPDSYKC-DYPESYRGTLLKDFHMSELSCN 578
Human 579 ITLLIVTIVATMLVLAVTVTSLCSYLD--LPW-YLRMVCQWTQTRRRARNIPLEELQRNLQFHAF 640
Human 641 ISYSGHDSFWVKNELLPNLE--KEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQ 703
Human 704 SEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLE------WPK 760 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| TLR1 | NP_003254.2 | leucine-rich repeat | 47..70 | CDD:275378 | 4/22 (18%) |
| LRR 1 | 54..77 | 5/22 (23%) | |||
| LRR_8 | 69..124 | CDD:316378 | 19/54 (35%) | ||
| leucine-rich repeat | 71..94 | CDD:275378 | 7/22 (32%) | ||
| LRR 2 | 78..101 | 8/22 (36%) | |||
| leucine-rich repeat | 95..115 | CDD:275378 | 9/19 (47%) | ||
| LRR 3 | 102..125 | 8/22 (36%) | |||
| leucine-rich repeat | 116..140 | CDD:275378 | 6/23 (26%) | ||
| LRR 4 | 126..150 | 6/38 (16%) | |||
| leucine-rich repeat | 141..152 | CDD:275378 | 3/25 (12%) | ||
| LRR 5 | 151..175 | 4/30 (13%) | |||
| LRR 6 | 176..199 | 4/22 (18%) | |||
| LRR 7 | 200..223 | 6/25 (24%) | |||
| LRR 8 | 224..250 | 6/28 (21%) | |||
| LRR 9 | 251..278 | 4/26 (15%) | |||
| LRR 10 | 279..308 | 5/37 (14%) | |||
| LRR 11 | 309..337 | 7/44 (16%) | |||
| Interaction with bacterial lipopeptide | 313..316 | 0/2 (0%) | |||
| LRR 12 | 338..361 | 5/33 (15%) | |||
| PLN00113 | <352..>560 | CDD:331614 | 45/242 (19%) | ||
| leucine-rich repeat | 352..373 | CDD:275380 | 4/35 (11%) | ||
| LRR 13 | 362..388 | 5/30 (17%) | |||
| leucine-rich repeat | 374..399 | CDD:275380 | 7/25 (28%) | ||
| LRR 14 | 389..414 | 5/24 (21%) | |||
| leucine-rich repeat | 400..424 | CDD:275380 | 6/23 (26%) | ||
| LRR 15 | 415..437 | 8/28 (29%) | |||
| leucine-rich repeat | 425..446 | CDD:275380 | 7/27 (26%) | ||
| LRR 16 | 438..457 | 5/18 (28%) | |||
| leucine-rich repeat | 447..469 | CDD:275380 | 4/21 (19%) | ||
| LRR 17 | 458..478 | 1/19 (5%) | |||
| leucine-rich repeat | 470..492 | CDD:275380 | 0/21 (0%) | ||
| LRR 18 | 479..500 | 0/20 (0%) | |||
| leucine-rich repeat | 494..515 | CDD:275380 | 2/20 (10%) | ||
| LRR 19 | 501..524 | 4/26 (15%) | |||
| LRRCT | 553..577 | CDD:279765 | 4/24 (17%) | ||
| TIR | 636..779 | CDD:214587 | 33/133 (25%) | ||
| Toll-4 | NP_523519.2 | leucine-rich repeat | 264..287 | CDD:275380 | |
| leucine-rich repeat | 288..308 | CDD:275380 | |||
| leucine-rich repeat | 309..334 | CDD:275380 | |||
| leucine-rich repeat | 335..386 | CDD:275380 | 0/2 (0%) | ||
| leucine-rich repeat | 388..408 | CDD:275380 | 5/22 (23%) | ||
| LRR_8 | 412..465 | CDD:290566 | 17/54 (31%) | ||
| leucine-rich repeat | 412..432 | CDD:275378 | 4/19 (21%) | ||
| LRR_4 | 432..470 | CDD:289563 | 15/41 (37%) | ||
| leucine-rich repeat | 433..454 | CDD:275378 | 7/22 (32%) | ||
| leucine-rich repeat | 455..478 | CDD:275378 | 11/26 (42%) | ||
| leucine-rich repeat | 479..490 | CDD:275378 | 4/16 (25%) | ||
| leucine-rich repeat | 632..657 | CDD:275378 | 3/24 (13%) | ||
| leucine-rich repeat | 658..679 | CDD:275378 | 5/27 (19%) | ||
| leucine-rich repeat | 680..706 | CDD:275378 | 2/25 (8%) | ||
| leucine-rich repeat | 707..719 | CDD:275378 | 3/14 (21%) | ||
| leucine-rich repeat | 771..791 | CDD:275380 | 6/19 (32%) | ||
| leucine-rich repeat | 793..815 | CDD:275378 | 9/29 (31%) | ||
| leucine-rich repeat | 816..835 | CDD:275378 | 5/20 (25%) | ||
| leucine-rich repeat | 836..859 | CDD:275378 | 6/66 (9%) | ||
| TIR | 974..1110 | CDD:214587 | 33/133 (25%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E2759_KOG4641 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D147327at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000239 | |
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | O | PTHR24365 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X221 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 6 | 5.920 | |||||