DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLN1 and SLA2

DIOPT Version :10

Sequence 1:NP_006280.3 Gene:TLN1 / 7094 HGNCID:11845 Length:2541 Species:Homo sapiens
Sequence 2:NP_014156.2 Gene:SLA2 / 855478 SGDID:S000005187 Length:968 Species:Saccharomyces cerevisiae


Alignment Length:1168 Identity:227/1168 - (19%)
Similarity:379/1168 - (32%) Gaps:418/1168 - (35%)


- Green bases have known domain annotations that are detailed below.


Human  1501 HTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIK--------ALD---------- 1547
            |.|||..:.|           .|.:::|...|.:..::..|.|:        .||          
Yeast    75 HPSALAEAIR-----------DRDWIRSLGRVHSGGSSYSKLIREYVRYLVLKLDFHAHHRGFNN 128

Human  1548 GAFTEENRAQCRAATAP---------LLEAVDNLSAFASNPEFSSIP-AQISPEGR------AAM 1596
            |.|..|......:.:.|         |:...|:|.      |||.|. |.|..|.|      :|:
Yeast   129 GTFEYEEYVSLVSVSDPDEGYETILDLMSLQDSLD------EFSQIIFASIQSERRNTECKISAL 187

Human  1597 EPIVISAKTMLESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLEC 1661
            .|::      .||.|                                |.|.||||          
Yeast   188 IPLI------AESYG--------------------------------IYKFITSM---------- 204

Human  1662 ETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQML------TAVQEISHLI------- 1713
                  |.:..|.|:.|...|..|.|..|    .|..|.::.      ::|:.::.|:       
Yeast   205 ------LRAMHRQLNDAEGDAALQPLKER----YELQHARLFEFYADCSSVKYLTTLVTIPKLPV 259

Human  1714 ----------------------EPLANAAR-------------AEASQLGHKVSQMAQ-----YF 1738
                                  ||....||             ||.:.....|||...     |.
Yeast   260 DAPDVFLINDVDESKEIKFKKREPSVTPARTPARTPTPTPPVVAEPAISPRPVSQRTTSTPTGYL 324

Human  1739 EPLTL---------AAVGAASKTLSHP-----------QQMALLDQTKTLAESALQLL---YTAK 1780
            :.:..         .|.|||:......           ||....::...|.:..:|.|   ...:
Yeast   325 QTMPTGATTGMMIPTATGAANAIFPQATAQMQPDFWANQQAQFANEQNRLEQERVQQLQQQQAQQ 389

Human  1781 EAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGE 1845
            |......|.|. |:.:...:|...:...||....|:.....    .::....|.:.||:      
Yeast   390 ELFQQQLQKAQ-QDMMNMQLQQQNQHQNDLIALTNQYEKDQ----ALLQQYDQRVQQLE------ 443

Human  1846 PEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRL-ASEAKPAAVAAEN 1909
                                   .|:.|..:|:.::|.....|||:...:| ..|.|..::|...
Yeast   444 -----------------------SEITTMDSTASKQLANKDEQLTALQDQLDVWERKYESLAKLY 485

Human  1910 EEIGSHIKHRVQELGHGCAALVTKAGALQC---SPSDAYTKKELIECARRVSEKVSHVLAALQAG 1971
            .::      |.:.|.     |:.:...||.   |..::..|||.:|  .::.:|      .||  
Yeast   486 SQL------RQEHLN-----LLPRFKKLQLKVNSAQESIQKKEQLE--HKLKQK------DLQ-- 529

Human  1972 NRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQN 2036
                         ::.::.|.|                            .|::.:|.:   :.|
Yeast   530 -------------MAELVKDRD----------------------------RARLELERS---INN 550

Human  2037 AAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAA 2101
            |.      |.:|.::.|..|...|.:          :|....:|.:.:..:.:::.:|       
Yeast   551 AE------ADSAAATAAAETMTQDKM----------NPILDAILESGINTIQESVYNL------- 592

Human  2102 AGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEAT----TEHIRQELAVFCS 2162
                 |.|..|      ...:|..|.||..:::..:.||:...:....    ..|..|...:.| 
Yeast   593 -----DSPLSW------SGPLTPPTFLLSLLESTSENATEFATSFNNLIVDGLAHGDQTEVIHC- 645

Human  2163 PEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPE 2227
                     ..||  .|...|:.|.....|..:..||.       |.:.:..:.|..:||.|..|
Yeast   646 ---------VSDF--STSMATLVTNSKAYAVTTLPQEQ-------SDQILTLVKRCAREAQYFFE 692

Human  2228 VAPDVRLRALHYGRECANGYLELLDHVL---LTLQKPSPELKQQLTGHSKRVAGSVTELIQAAEA 2289
            ......|..:        |..|..|.|:   :.:|:...||...:            |.:...::
Yeast   693 DLMSENLNQV--------GDEEKTDIVINANVDMQEKLQELSLAI------------EPLLNIQS 737

Human  2290 MKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAA 2354
            :|..:..:|       .:||:..|..|   .|..|.|:           ::..:.:|..|..|..
Yeast   738 VKSNKETNP-------HSELVATADKI---VKSSEHLR-----------VDVPKPLLSLALMIID 781

Human  2355 ATSALVKAASAAQRELVAQGKVGAIPANA--LDDGQWSQGLISAARMVAAATNNLCEAANAAVQG 2417
            |..||||||...|.|:..   ..:||.|.  |.:.:|::||||||:.||.|||.|...|:..:..
Yeast   782 AVVALVKAAIQCQNEIAT---TTSIPLNQFYLKNSRWTEGLISAAKAVAGATNVLITTASKLITS 843

Human  2418 ----HASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQ-----------AAGNAVKRAS 2467
                :.|.|:.|.::|:|||||.||:.|.:||....|:|..:|:           :.||.|....
Yeast   844 EDNENTSPEQFIVASKEVAASTIQLVAASRVKTSIHSKAQDKLEHCSKDVTDACRSLGNHVMGMI 908

Human  2468 DNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQY 2530
            ::....:|:....:.....|:...|         :..|.|:|:.|:.|..|||:|.:||:..|
Yeast   909 EDDHSTSQQQQPLDFTSEHTLKTAE---------MEQQVEILKLEQSLSNARKRLGEIRRHAY 962

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLN1NP_006280.3 FERM_F0_TLN1 2..85 CDD:340691
FERM_F1_TLN1 86..197 CDD:340693
B41 88..313 CDD:214604
Interaction with LAYN. /evidence=ECO:0000250|UniProtKB:P54939 280..435
FERM_C_Talin 309..400 CDD:269973
Helical bundle R1. /evidence=ECO:0000250|UniProtKB:P26039 482..655
Talin_middle 491..652 CDD:462691
ILWEQ 607..>759 CDD:214607
Helical bundle R2. /evidence=ECO:0000250|UniProtKB:P26039 656..786
Helical bundle R3. /evidence=ECO:0000250|UniProtKB:P26039 787..911
Helical bundle R4. /evidence=ECO:0000250|UniProtKB:P26039 913..1044
talin-RS 1043..1197 CDD:213393
Helical bundle R5. /evidence=ECO:0000250|UniProtKB:P26039 1046..1206
talin-RS 1204..1351 CDD:213393
Helical bundle R6. /evidence=ECO:0000250|UniProtKB:P26039 1207..1357
Interaction with SYNM. /evidence=ECO:0000269|PubMed:18342854 1327..1948 97/560 (17%)
Helical bundle R7A. /evidence=ECO:0000250|UniProtKB:P26039 1358..1453
Interaction with VCL and F-actin. /evidence=ECO:0000250|UniProtKB:P26039 1359..1659 38/191 (20%)
Helical bundle R8. /evidence=ECO:0000250|UniProtKB:P26039 1461..1580 19/105 (18%)
Helical bundle R7B. /evidence=ECO:0000250|UniProtKB:P26039 1581..1653 18/78 (23%)
talin-RS 1654..1826 CDD:213393 39/247 (16%)
Helical bundle R9. /evidence=ECO:0000250|UniProtKB:P26039 1655..1822 39/242 (16%)
Helical bundle R10. /evidence=ECO:0000250|UniProtKB:P26039 1823..1973 27/153 (18%)
VBS 1849..1973 CDD:430312 24/127 (19%)
Helical bundle R11. /evidence=ECO:0000250|UniProtKB:P26039 1974..2140 21/165 (13%)
Helical bundle R12. /evidence=ECO:0000250|UniProtKB:P26039 2141..2294 27/159 (17%)
Helical bundle R13. /evidence=ECO:0000250|UniProtKB:P26039 2300..2482 58/198 (29%)
ILWEQ 2336..2532 CDD:214607 65/212 (31%)
SLA2NP_014156.2 ANTH 7..269 CDD:400137 50/268 (19%)
DR0291 420..>546 CDD:441187 31/220 (14%)
ILWEQ 763..965 CDD:214607 66/223 (30%)
Blue background indicates that the domain is not in the aligned region.

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