Protein Alignment TLN1 and tln1

DIOPT Version :10

• Sequence 1: NP_006280.3
• Gene: TLN1 / 7094
• HGNCID: 11845
• Length: 2541
• Species: Homo sapiens
• Sequence 2: XP_031750909.1
• Gene: tln1 / 733752
• XenbaseID: XB-GENE-6039297
• Length: 2558
• Species: Xenopus tropicalis
• Alignment Length: 2558
• Identity: 2186/2558 - (85%)
• Similarity: 2368/2558 - (92%)
• Gaps: 20/2558 - (0%)

Human     1 MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPPSDFGLFLSDDDPKKGIWLEAG 65
            ||||||||||||||||||||||||:||||||||||:|||..|.|:||||||||:|||||||||||
 Frog     1 MVALSLKISIGNVVKTMQFEPSTMIYDACRIIRERVPEAQIGQPNDFGLFLSDEDPKKGIWLEAG 65

Human    66 KALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLV 130
            |||||||||||||:||||||||||||||||||||:|||||||::|:||||||||||||:||||||
 Frog    66 KALDYYMLRNGDTLEYRKKQRPLKIRMLDGTVKTVMVDDSKTMSDLLMTICARIGITNYDEYSLV 130

Human   131 RELMEEKKEEITGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRR 195
            ||:||||||||||||::|||||||:||||||||||||||||||||.|||||||||:|:|||||||
 Frog   131 REIMEEKKEEITGTLKRDKTLLRDDKKMEKLKQKLHTDDELNWLDPGRTLREQGVDENETLLLRR 195

Human   196 KFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFL 260
            |||||||||||||||||||||||||||||||||||||||||||||:|||:|||||||.|||.|||
 Frog   196 KFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGYQCQVQFGPHNEVKHKPGFL 260

Human   261 DLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKL 325
            :|||||||||:|||||||||.||:.||.|||||||.|||||||||||||||||||||||||||||
 Frog   261 ELKDFLPKEYIKQKGERKIFLAHRQCGNMSEIEAKARYVKLARSLKTYGVSFFLVKEKMKGKNKL 325

Human   326 VPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQ 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   326 VPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQ 390

Human   391 LIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRS 455
            ||||||||||||||||||||||||||||||||||||||||:||||:|:|||||||||||||||||
 Frog   391 LIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTLLQQQFNQVGKVEHGSVALPAIMRS 455

Human   456 GASGPENFQVGSMPPAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFDTLP 520
            ||||||||||||||.||||..|||||.|||||||||||||||||||||||:.|||||||||||||
 Frog   456 GASGPENFQVGSMPQAQQQTVSGQMHLGHMPPLTSAQQALTGTINSSMQAINAAQATLDDFDTLP 520

Human   521 PLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLT 585
            |||.|||||||||||||.|||||||||||||||||||||||||:||:||||||||||||||||||
 Frog   521 PLGDDAASKAWRKNKMDNSKHEIHSQVDAITAGTASVVNLTAGNPADTDYTAVGCAVTTISSNLT 585

Human   586 EMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGE 650
            ||||||||||||:|||||:||.||.|||.||||||:||::|||||.||||.|:|||||||.||||
 Frog   586 EMSRGVKLLAALMEDEGGNGRQLLHAAKNLAGAVSDLLKTAQPASTEPRQVLMQAAGNVGMASGE 650

Human   651 LLQQIGESDTDPHFQ------------------DALMQLAKAVASAAAALVLKAKSVAQRTEDSG 697
            ||:||||.|||..||                  |.|:||||||||||||||||||:||:||:|..
 Frog   651 LLKQIGECDTDSQFQISAARATRGLTPLAEQKTDMLVQLAKAVASAAAALVLKAKNVAERTDDGA 715

Human   698 LQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQ 762
            .||||||||||||||||||||||||||||||||||||||:|||:.|||:|||||.||:||.:|.:
 Frog   716 QQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLLEAGKQVAKSVEGCVEASEAAVQDPE 780

Human   763 LLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQAR 827
            ||:.||.||:|||||||:||||:|.||:|..|.|||||||||||.||||||||||||||||||||
 Frog   781 LLKAVGVAASAVTQALNDLLQHIKKHASGGPPTGRYDQATDTILNVTENIFSSMGDAGEMVRQAR 845

Human   828 ILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLRE 892
            ||||||||||.|||||||.|||||||||||||||:||||||:|||||||||||||||||||:|||
 Frog   846 ILAQATSDLVGAIKADAERESDLENSRKLLSAAKLLADATARMVEAAKGAAAHPDSEEQQQKLRE 910

Human   893 AAEGLRMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCK 957
            ||||||||||||||||||||||.:||.|||||||||||||||||:|||:.|..|..|. ||||||
 Frog   911 AAEGLRMATNAAAQNAIKKKLVHKLEQAAKQAAASATQTIAAAQNAASSNKNPAAQQQ-LVQSCK 974

Human   958 AVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQ 1022
            .||:|||:|||||||||:|||||||||:||:|||:|||||.|:|||.||:|||:.|.||||||.|
 Frog   975 VVADQIPMLVQGVRGSQSQPDSPSAQLSLISASQNFLQPGAKLVAAGKAAVPTVSDPASAMQLGQ 1039

Human  1023 CAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGETMEKC 1087
            |.|||.:||||||||||||.|||||||:||||::|::||:||||.:||||:|||:||||||||||
 Frog  1040 CTKNLASALAELRTAAQKAHEACGPLEIDSALNLVRSLEQDLQEARAAAREGKLQPLPGETMEKC 1104

Human  1088 TQDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPAVQAIVL 1152
            .||||:|||||||:|||||||:..|||||.|.||||||..|||||||:|||||.::|||||..:|
 Frog  1105 AQDLGSSTKAVSSSIAQLLGEIVHGNENYTGRAARDVAQALRSLAQASRGVAANSTDPAVQNAML 1169

Human  1153 DTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDVDNALRAVG 1217
            :.|.||:|||.:||||||:|.|.|.|||.|||||||||||:|||:|||:|||||||||.|::::|
 Frog  1170 ECAEDVMDKAGNLIEEAKRAVGKPTDPEGQQRLAQVAKAVSQALSRCVNCLPGQRDVDAAIKSIG 1234

Human  1218 DASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLARASGRFGQDFSTFL 1282
            :|||.||:.|.||.|..|||||.:||:|||||||:|.||||||||||||||:|||::..||:.||
 Frog  1235 EASKILLASSFPPGTKNFQEAQGQLNQAAAGLNQSANELVQASRGTPQDLAKASGKYSHDFNEFL 1299

Human  1283 EAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAPNLKSQLAAAARAVTDSIN 1347
            :||||||||:.::||:||||||||.||:|||||||||||||.|||||||||||||||||||||||
 Frog  1300 QAGVEMAGQSQNKEDQAQVVSNLKSISLSSSKLLLAAKALSADPAAPNLKSQLAAAARAVTDSIN 1364

Human  1348 QLITMCTQQAPGQKECDNALRELETVRELLENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQ 1412
            ||||:|||||||||||||||||||||||||:||.:|:||.|||.||||||||||||||:|.||||
 Frog  1365 QLITVCTQQAPGQKECDNALRELETVRELLQNPTEPVNDQSYFHCLDSVMENSKVLGESMAGISQ 1429

Human  1413 NAKNGNLPEFGDAISTASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMA 1477
            |||..||||||:::|.|||||||.||||||||||||||||||.|||||||:||||||||||||||
 Frog  1430 NAKTCNLPEFGESVSAASKALCGLTEAAAQAAYLVGVSDPNSHAGQQGLVDPTQFARANQAIQMA 1494

Human  1478 CQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKT 1542
            ||:||:|.|||:||||||||||||||||||:||:||..|:||.||||||||||||||||||||||
 Frog  1495 CQNLGDPACTQSQVLSAATIVAKHTSALCNACRVASTHTSNPVAKRQFVQSAKEVANSTANLVKT 1559

Human  1543 IKALDGAFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTML 1607
            ||||||||.::||.:||.||.||::||:||:||||||||:|:||||||||..||||||.:||.||
 Frog  1560 IKALDGAFNDDNRVKCRNATVPLIQAVENLTAFASNPEFASVPAQISPEGLRAMEPIVTAAKLML 1624

Human  1608 ESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCL 1672
            ||:.|||||||:||.||:|||.||||||||||||||||||||:||||||||.||:.||..||..:
 Frog  1625 ESSSGLIQTARSLAANPKDPPQWSVLAGHSRTVSDSIKKLITNMRDKAPGQRECDQAIELLNQSV 1689

Human  1673 RDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQLGHKVSQMAQY 1737
            ||||||||.|:|||||||||||||||||||.|:|||||:||||:|.||||::|||||||||||||
 Frog  1690 RDLDQASLEAISQQLAPREGISQEALHTQMQTSVQEISNLIEPMAAAARADSSQLGHKVSQMAQY 1754

Human  1738 FEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQM 1802
            |||||.||:||||||::|.|||.||||||||||||||:|||:||||||||.||||||||:||.||
 Frog  1755 FEPLTHAAIGAASKTINHQQQMNLLDQTKTLAESALQMLYTSKEAGGNPKVAAHTQEALDEAAQM 1819

Human  1803 MTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRTAKAIAVT 1867
            |.|||||||.||||||||||.|||||||||||||:|||.|.|||||||||||||||:||||||||
 Frog  1820 MHEAVEDLTVTLNEAASAAGAVGGMVDSITQAINKLDEEPAGEPEGSFVDYQTTMVKTAKAIAVT 1884

Human  1868 VQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGSHIKHRVQELGHGCAALVT 1932
            ||||||||.|:|:|||.||||||::||:||.||||||:.|||||||||||.|||||||.|:.|||
 Frog  1885 VQEMVTKSTTNPDELGTLANQLTNEYGQLAQEAKPAAMTAENEEIGSHIKQRVQELGHNCSLLVT 1949

Human  1933 KAGALQCSPSDAYTKKELIECARRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIM 1997
            |||||||||:|:||||||||.||||||||||||||||||||||||||||||||||||||||||||
 Frog  1950 KAGALQCSPNDSYTKKELIESARRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIM 2014

Human  1998 FATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVV 2062
            ||||||||||..|||||||||||||||.||||||||||||..|||||||||||||.||||||:.|
 Frog  2015 FATAGTLNRENAETFADHREGILKTAKALVEDTKVLVQNATSSQEKLAQAAQSSVTTITRLAETV 2079

Human  2063 KLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTS 2127
            ||||||||||||||||||||||||||||||||||||||||||..|||:|:|||||||||||||||
 Frog  2080 KLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKSSDDPSVYQLKNSAKVMVTNVTS 2144

Human  2128 LLKTVKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAA 2192
            ||||||||||||||||||||||.||||||||||.|||||.:||||||||||||||||||||||||
 Frog  2145 LLKTVKAVEDEATKGTRALEATIEHIRQELAVFSSPEPPPQTSTPEDFIRMTKGITMATAKAVAA 2209

Human  2193 GNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLT 2257
            |||||||||||||||||||||||||:||||.|||||..|||:||..:|:|||.|||:||:||||.
 Frog  2210 GNSCRQEDVIATANLSRRAIADMLRSCKEAVYHPEVNADVRMRATRFGKECAIGYLQLLEHVLLI 2274

Human  2258 LQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKK 2322
            ||||||||||||..|||:|||||||||||||||||||||||||||||||||||||||||||||||
 Frog  2275 LQKPSPELKQQLATHSKQVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKK 2339

Human  2323 LEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDG 2387
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||.|||
 Frog  2340 LEQLKPRAKPKQADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANADDDG 2404

Human  2388 QWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEA 2452
            |||||||||||||||||:|||||||:|||||||:||||||||||||||||||||||||||.||||
 Frog  2405 QWSQGLISAARMVAAATSNLCEAANSAVQGHASEEKLISSAKQVAASTAQLLVACKVKADHDSEA 2469

Human  2453 MKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEE 2517
            |:|||.||||||||||||||||||||||::.: ||||||||||||||||||||||||||||||||
 Frog  2470 MRRLQVAGNAVKRASDNLVKAAQKAAAFQDHD-ETVVVKEKMVGGIAQIIAAQEEMLRKERELEE 2533

Human  2518 ARKKLAQIRQQQYKFLPSELRDE 2540
            ||||||.||||||||||||||::
 Frog  2534 ARKKLAMIRQQQYKFLPSELRED 2556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TLN1	NP_006280.3	FERM_F0_TLN1	2..85	CDD:340691	74/82 (90%)
		FERM_F1_TLN1	86..197	CDD:340693	98/110 (89%)
		B41	88..313	CDD:214604	201/224 (90%)
		Interaction with LAYN. /evidence=ECO:0000250|UniProtKB:P54939	280..435		148/154 (96%)
		FERM_C_Talin	309..400	CDD:269973	90/90 (100%)
		Helical bundle R1. /evidence=ECO:0000250|UniProtKB:P26039	482..655		152/172 (88%)
		Talin_middle	491..652	CDD:462691	142/160 (89%)
		ILWEQ	607..>759	CDD:214607	123/169 (73%)
		Helical bundle R2. /evidence=ECO:0000250|UniProtKB:P26039	656..786		103/147 (70%)
		Helical bundle R3. /evidence=ECO:0000250|UniProtKB:P26039	787..911		112/123 (91%)
		Helical bundle R4. /evidence=ECO:0000250|UniProtKB:P26039	913..1044		99/130 (76%)
		talin-RS	1043..1197	CDD:213393	114/153 (75%)
		Helical bundle R5. /evidence=ECO:0000250|UniProtKB:P26039	1046..1206		118/159 (74%)
		talin-RS	1204..1351	CDD:213393	112/146 (77%)
		Helical bundle R6. /evidence=ECO:0000250|UniProtKB:P26039	1207..1357		114/149 (77%)
		Interaction with SYNM. /evidence=ECO:0000269|PubMed:18342854	1327..1948		516/620 (83%)
		Helical bundle R7A. /evidence=ECO:0000250|UniProtKB:P26039	1358..1453		79/94 (84%)
		Interaction with VCL and F-actin. /evidence=ECO:0000250|UniProtKB:P26039	1359..1659		247/299 (83%)
		Helical bundle R8. /evidence=ECO:0000250|UniProtKB:P26039	1461..1580		96/118 (81%)
		Helical bundle R7B. /evidence=ECO:0000250|UniProtKB:P26039	1581..1653		57/71 (80%)
		talin-RS	1654..1826	CDD:213393	140/171 (82%)
		Helical bundle R9. /evidence=ECO:0000250|UniProtKB:P26039	1655..1822		136/166 (82%)
		Helical bundle R10. /evidence=ECO:0000250|UniProtKB:P26039	1823..1973		127/149 (85%)
		VBS	1849..1973	CDD:430312	105/123 (85%)
		Helical bundle R11. /evidence=ECO:0000250|UniProtKB:P26039	1974..2140		153/165 (93%)
		Helical bundle R12. /evidence=ECO:0000250|UniProtKB:P26039	2141..2294		132/152 (87%)
		Helical bundle R13. /evidence=ECO:0000250|UniProtKB:P26039	2300..2482		173/181 (96%)
		ILWEQ	2336..2532	CDD:214607	182/195 (93%)
tln1	XP_031750909.1	FERM_F0_TLN1	2..85	CDD:340691	74/82 (90%)
		FERM_F1_TLN1	86..197	CDD:340693	98/110 (89%)
		FERM_M	201..313	CDD:459788	100/111 (90%)
		FERM_C_Talin	309..400	CDD:269973	90/90 (100%)
		Talin_middle	491..652	CDD:462691	142/160 (89%)
		ILWEQ	607..>775	CDD:214607	121/167 (72%)
		talin-RS	1671..1833	CDD:213393	131/161 (81%)
		VBS	1866..1990	CDD:430312	105/123 (85%)
		VBS	2028..2151	CDD:430312	112/122 (92%)
		ILWEQ	2353..2548	CDD:214607	182/195 (93%)