DRSC/TRiP Functional Genomics Resources

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Protein Alignment TLN1 and rhea

DIOPT Version :10

Sequence 1:NP_006280.3 Gene:TLN1 / 7094 HGNCID:11845 Length:2541 Species:Homo sapiens
Sequence 2:NP_648238.1 Gene:rhea / 38978 FlyBaseID:FBgn0260442 Length:2836 Species:Drosophila melanogaster


Alignment Length:2570 Identity:1219/2570 - (47%)
Similarity:1708/2570 - (66%) Gaps:77/2570 - (2%)


- Green bases have known domain annotations that are detailed below.


Human     1 MVALSLKISI--GNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPPSDFGLFLSDDDPKKGIWLE 63
            |..|||:|.:  |.|.||:||:|:|.|:|||::||::..||..|.||::|||:||:..::|:|||
  Fly     1 MSTLSLRIQLEGGRVTKTIQFQPNTTVFDACKVIRDKFAEAVQGQPSEYGLFISDEQNQQGVWLE 65

Human    64 AGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYS 128
            .|:.|.||:|.|.||:|||:|.|.|::|||||.||||:||||:.|:.:::.||.:||||||:||.
  Fly    66 PGRTLGYYILHNQDTLEYRRKTRTLRVRMLDGAVKTILVDDSQPVSQLMVVICTKIGITNHEEYG 130

Human   129 LVRELMEEKKEEIT----GTLR-KDKTLLRD-EKKMEKLKQKLHTDDELNWLDHGRTLREQGVEE 187
            ||||..|.:.|.:.    |||. |.|.:.:| :.|||.|::||.||||:||:|..|||||||::|
  Fly   131 LVREDNEAQNENLPDNKFGTLTLKRKIMEKDRDAKMESLRKKLKTDDEMNWVDVSRTLREQGIDE 195

Human   188 HETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNE 252
            .||:||||:||:||||:|||||||||||||||||.||:|:|||:.||||||||.|..||||||||
  Fly   196 AETVLLRRRFFFSDQNIDSRDPVQLNLLYVQARDAILDGTHPVTQDKACEFAGIQVHIQFGPHNE 260

Human   253 QKHKAGFLDLKDFLPKEYVKQKG-ERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVK 316
            .|||.||||||||||:.||:.|| |:|||..|:....:|||:|||.|.|.||.|.||||:|||||
  Fly   261 AKHKTGFLDLKDFLPQSYVRTKGIEKKIFSEHRKHVDLSEIDAKVLYTKTARELPTYGVTFFLVK 325

Human   317 EKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQ 381
            |||.|||||||||||:||:.|:|:||.|||::..|.||.::||.|||.:||||||||.:.|||||
  Fly   326 EKMNGKNKLVPRLLGVTKDSVLRLDEHTKEILISWPLTTVRRWGASPNTFTLDFGDYANQYYSVQ 390

Human   382 TTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGS 446
            |||.|||.||||||||||||||::|||||:||||.|||:|:||:|.|:|.||.:.||:.::...|
  Fly   391 TTEAEQIVQLIAGYIDIILKKKQTKDHFGIEGDEGSTMVEESVAPSKATFLQHETNRMEQLNVES 455

Human   447 VALPAIMRSGASGPENFQVGSMPPAQQQITSGQMHRGHMPP-----------LTSAQQALTGTIN 500
            :|.|.|||. ..|..::....:...|.....||::..|.||           ||..|:||.|.|:
  Fly   456 LAHPGIMRP-YDGERSYMENEVQTVQYGAFVGQVNHAHQPPTTKEVRISSVNLTEPQRALLGYIS 519

Human   501 SSMQAVQAAQATLDDFDTLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDP 565
            :....:..|...|.....:..||.|..|..||:|.:|.||..:.|.|..::|.||.::  ||..|
  Fly   520 AGQDVLIRADEELRTKAPIQELGSDLRSIEWRENTLDTSKQAVSSHVATMSAATAQII--TASHP 582

Human   566 AETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRSAQPAS 630
            .|.|..|:..:|:.|:..:.|:::.|:|:|||:|:: .||..||:||:.|..|.|:||::|:|.|
  Fly   583 DEVDTEAISASVSQIAQTIPEVTKEVRLIAALMEND-TSGDQLLEAARNLCSAFSDLLKAAEPES 646

Human   631 AEPRQNLLQAAGNVGQASGELLQQIGESDT----DPHFQDALMQLAKAVASAAAALVLKAKSVAQ 691
            .||.|:|:.||..||:|:..:|..|.|.:.    |.|  |.|:.||||||:..|||||:||::|.
  Fly   647 KEPPQHLINAASRVGEATTHVLSTIAEEEVPENRDLH--DMLLALAKAVANTTAALVLRAKNIAA 709

Human   692 RTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQA 756
            ..:|...:.:||.||:||||:|||||||.||||||:.:..|:|||..|.:.||:||.........
  Fly   710 SCDDEQARNRVIGAASQCALATSQLVACAKVVAPTLHNAACREQLEAAAKNVARAVNSLCEVCNE 774

Human   757 ATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQATDTILTVTEN------IFSS 815
            |:.|.:|...:.|||..|:::|.::|:|||..:.      .:...|.|.|:..||      |..|
  Fly   775 ASNDPKLKADLLAAARDVSKSLTDMLEHVKLSSR------EHANRTSTELSPVENVIIGTDILVS 833

Human   816 MGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAH 880
            ..|..||||.||.|.|.|:.|:.:||.:|:.:.|.:..|.||||||.|||||||:||||:..:::
  Fly   834 THDPQEMVRHARTLGQTTAQLIQSIKGEADQQQDADMKRHLLSAAKQLADATAKLVEAARLCSSN 898

Human   881 PDSEEQQQRLREAAEGLRMATNAAAQN-AIKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKA 944
            |...:.|..||:|||.||..|..||.. |:|:.|:||||..:||||::|||.|:|||:|....:.
  Fly   899 PHDSDNQNALRKAAEELREITTTAANTPAMKRGLIQRLEFCSKQAASAATQCISAAQNAVQHSQD 963

Human   945 SAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVP 1009
            ....:.|| |.||.||:.||.||..::.::||||.|:|||.||.|::.|::|..::..:::|..|
  Fly   964 HQTKETLL-QDCKRVADTIPRLVTSLKTTRAQPDDPNAQLNLIEAAEQFIEPALQVSKSSRALQP 1027

Human  1010 TIQDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDG 1074
            |:.|..||.|||:.|.:||..::||.:.||:|::|||..|::|||..|:.|...|.:.:.||..|
  Fly  1028 TVTDIPSATQLSKGALHLGQCVSELHSVAQRARDACGGQELESALEEVRKLHDVLDDTRQAAIAG 1092

Human  1075 KLKPLPGETMEKCTQDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVA 1139
            :|:||||:|:|....:|..|.|.|..|::|||..|.....:|||.|.||.|..|....::..|||
  Fly  1093 QLRPLPGQTVENTADELRKSAKNVGIALSQLLSSVLHNQRSYAGAAGRDTALALGDFTRSVHGVA 1157

Human  1140 ALTSDPAVQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLP 1204
            |.|.:||    ::|.|.||:..::.|||:|::......:||:   |.|..:.||.||:..|.|:|
  Fly  1158 ATTQNPA----IIDCADDVVTSSARLIEQAQRTLQGASNPEA---LTQAGREVTGALSATVDCIP 1215

Human  1205 GQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLAR 1269
            |||:||.|||.|.:.|:.|.....|||:..:...||.|.:.|..|:.|..|:| .|..:|..||.
  Fly  1216 GQREVDVALRNVSELSEILSMSEFPPSSRPYATLQSELKQVAEQLSSAGGEIV-VSYSSPALLAE 1279

Human  1270 ASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAPNLKSQ 1334
            :|..|..::...|...:|||||...:|.|:.::.:|:.:|..|..||..||:::.||..||.|:.
  Fly  1280 SSQNFAANYRDLLSVSMEMAGQTQEEEVRSHMIESLRHVSTQSCSLLSTAKSIAADPGQPNAKNL 1344

Human  1335 LAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENPVQPINDMSYFGCLDSVMEN 1399
            |.||||.||:|||||:....|.||||||||||:|.:|.:|.:|:.|.:|||::.||.|::.....
  Fly  1345 LHAAARGVTESINQLVDASIQSAPGQKECDNAMRNIEALRLMLDYPHEPINELGYFDCVEQATGK 1409

Human  1400 SKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEP 1464
            |:.||.|::.:..|||.....||..:::..:.::.|..|:::|||||:|||.|:|.||:.|:::.
  Fly  1410 SRNLGYAISEMINNAKQSQHVEFSQSVNNVNDSIQGLIESSSQAAYLIGVSHPSSVAGRPGIIDQ 1474

Human  1465 TQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTTNPTAKRQFVQSA 1529
            .|...|.|.|:..|..:.....|:.|::||.|::|||||.||:.||.||..|:||.||.:|:..|
  Fly  1475 AQLTWAYQGIRQHCDIVSSQQSTKPQMISALTVIAKHTSYLCSICRQASMNTSNPVAKNEFIVLA 1539

Human  1530 KEVANSTANLVKTIKALDGAFTEENRAQCRAATA-PLLEAVDNLSAFASNPEFSSIPAQISPEGR 1593
            |:||.:|::||:.|||::    |::....|.... ||||||..:..:||:.||||:||:||.|||
  Fly  1540 KQVATATSDLVQDIKAIE----EQSAGGSRERLVDPLLEAVKAVRQYASSSEFSSVPAKISAEGR 1600

Human  1594 AAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQ 1658
            .|.||::.:.:.:::....:::.|::||:.|.:||.|..|:.||..||:|:|:|:.::|||||||
  Fly  1601 KAQEPVIQAGRGVIDGVVEMVKAAKSLALTPDNPPVWQQLSMHSTPVSESVKRLVDNIRDKAPGQ 1665

Human  1659 LECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAE 1723
            .:||..:..|.:|.|:||..:||..:|.|:.|...:......|.:.:..|:...:||:..|.:..
  Fly  1666 AQCEQVLHTLGTCTRELDSCALAVNAQGLSQRRDNNLHGFSGQTMNSASELIDKLEPIRMAGKNN 1730

Human  1724 ASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQ 1788
            |.||||.|.::::|..|:...|:||.:..:...|||:|:.||:::.|||:.|:.:|||:.|||: 
  Fly  1731 AEQLGHAVGEISRYVVPMVNGAIGACTHIVHSQQQMSLIQQTRSVVESAITLVQSAKESAGNPR- 1794

Human  1789 AAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGS---- 1849
            |.|....|::|:....||:::|..|:.:..:..|:|.|:::.:.::|.:|.:........|    
  Fly  1795 ATHAHPRLDDAIDGTREAIQELQQTVEKINAETGIVTGLMEQVNRSITRLTDKRQSLLNASYSDT 1859

Human  1850 FVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGS 1914
            ||||||.||..||.||....||..||:..|..|..||..:|.:|.:|..::..|:....:.::..
  Fly  1860 FVDYQTRMVARAKEIASLANEMNAKSSVEPSALPQLAVDMTQNYQQLTQDSVGASTTTSSPDVAM 1924

Human  1915 HIKHRVQELGHGCAALV-TKAGALQCSPSDAYTKKELIECARRVSEKVSHVLAALQAGNRGTQAC 1978
            .|:..|.:||...:::: :.||..:  |:||..:||:...||.|||||:.||||||||:||||||
  Fly  1925 RIRTTVIDLGRSVSSMIQSSAGGAR--PNDAGAQKEIARSAREVSEKVAQVLAALQAGSRGTQAC 1987

Human  1979 ITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNAAGSQEK 2043
            |.||..|||||.||||||||||||||:.:|..:||||||.||:|||.|||||||||..|||:|::
  Fly  1988 INAAHTVSGIIGDLDTTIMFATAGTLHSDGDGSFADHREHILQTAKALVEDTKVLVTGAAGTQDQ 2052

Human  2044 LAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDD 2108
            ||.|||::|:|||:||:.||.||.|||:..|::||::||||||||.||||||:.||.|:||..:|
  Fly  2053 LANAAQNAVSTITQLAEAVKRGACSLGSTQPDSQVMVINAVKDVASALGDLINCTKLASGKSIND 2117

Human  2109 PAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTST-P 2172
            |::..||.||:|||.||:||||||||||||.|:||||:|||.|.|.||:....||.|...|.. |
  Fly  2118 PSMQDLKESARVMVLNVSSLLKTVKAVEDEHTRGTRAMEATVEAISQEIRAMHSPPPVGNTQVGP 2182

Human  2173 EDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRAL 2237
            ||.||:|..:|.|||||||||.|..|.|:::.|||.||||::||..|:..|::.....::|.|.|
  Fly  2183 EDLIRVTMNVTAATAKAVAAGTSNLQADIVSAANLGRRAISEMLIVCRSVAWNCAETEELRSRTL 2247

Human  2238 HYGRECANGYLELLDHVLLTLQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPT 2302
            ..|......|.:||..:   |...|.:.:..|   |:|||..||:|:..|..:||::|:||||||
  Fly  2248 EAGTAVGESYRDLLSGI---LHNCSADDRMHL---SRRVAKCVTDLVAMARLLKGSDWIDPEDPT 2306

Human  2303 VIAENELLGAAAAIEAAAKKLEQLKPRAKPK---EADESLNFEEQILEAAKSIAAATSALVKAAS 2364
            ||||||||||||:|:||||||..|:||.:..   |.||::.|:|.||||||.|..|::|||:||:
  Fly  2307 VIAENELLGAAASIDAAAKKLASLRPRRQADVKIELDENMKFDEMILEAAKGIMGASAALVRAAN 2371

Human  2365 AAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAK 2429
            ||||||:..|||...|..:.||||||:|||||||:|||||::|.|||...|:|..::|.|||:||
  Fly  2372 AAQRELIDTGKVARRPLTSSDDGQWSEGLISAARLVAAATHSLVEAAQNLVRGVGTEEMLISTAK 2436

Human  2430 QVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVVKEKM 2494
            ||||||||||:|||||::.:|||.:|||||||||.:::||||.:||:  ..|.:|..::.:...|
  Fly  2437 QVAASTAQLLIACKVKSNPNSEAGRRLQAAGNAVIKSTDNLVHSAQQ--GLEAEEEHSLKINTSM 2499

Human  2495 VGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQ 2529
            |.|:||.|.|:..:||||:||||||:.|..:|..|
  Fly  2500 VDGMAQEINARSAVLRKEKELEEARQLLKNVRHAQ 2534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLN1NP_006280.3 FERM_F0_TLN1 2..85 CDD:340691 43/84 (51%)
FERM_F1_TLN1 86..197 CDD:340693 65/116 (56%)
B41 88..313 CDD:214604 147/231 (64%)
Interaction with LAYN. /evidence=ECO:0000250|UniProtKB:P54939 280..435 106/154 (69%)
FERM_C_Talin 309..400 CDD:269973 66/90 (73%)
Helical bundle R1. /evidence=ECO:0000250|UniProtKB:P26039 482..655 66/183 (36%)
Talin_middle 491..652 CDD:462691 60/160 (38%)
ILWEQ 607..>759 CDD:214607 74/155 (48%)
Helical bundle R2. /evidence=ECO:0000250|UniProtKB:P26039 656..786 60/133 (45%)
Helical bundle R3. /evidence=ECO:0000250|UniProtKB:P26039 787..911 53/130 (41%)
Helical bundle R4. /evidence=ECO:0000250|UniProtKB:P26039 913..1044 58/130 (45%)
talin-RS 1043..1197 CDD:213393 59/153 (39%)
Helical bundle R5. /evidence=ECO:0000250|UniProtKB:P26039 1046..1206 61/159 (38%)
talin-RS 1204..1351 CDD:213393 61/146 (42%)
Helical bundle R6. /evidence=ECO:0000250|UniProtKB:P26039 1207..1357 59/149 (40%)
Interaction with SYNM. /evidence=ECO:0000269|PubMed:18342854 1327..1948 235/626 (38%)
Helical bundle R7A. /evidence=ECO:0000250|UniProtKB:P26039 1358..1453 39/94 (41%)
Interaction with VCL and F-actin. /evidence=ECO:0000250|UniProtKB:P26039 1359..1659 125/300 (42%)
Helical bundle R8. /evidence=ECO:0000250|UniProtKB:P26039 1461..1580 47/119 (39%)
Helical bundle R7B. /evidence=ECO:0000250|UniProtKB:P26039 1581..1653 28/71 (39%)
talin-RS 1654..1826 CDD:213393 59/171 (35%)
Helical bundle R9. /evidence=ECO:0000250|UniProtKB:P26039 1655..1822 56/166 (34%)
Helical bundle R10. /evidence=ECO:0000250|UniProtKB:P26039 1823..1973 55/154 (36%)
VBS 1849..1973 CDD:430312 51/128 (40%)
Helical bundle R11. /evidence=ECO:0000250|UniProtKB:P26039 1974..2140 115/165 (70%)
Helical bundle R12. /evidence=ECO:0000250|UniProtKB:P26039 2141..2294 65/153 (42%)
Helical bundle R13. /evidence=ECO:0000250|UniProtKB:P26039 2300..2482 116/184 (63%)
ILWEQ 2336..2532 CDD:214607 112/194 (58%)
rheaNP_648238.1 FERM_f0 4..85 CDD:465152 42/80 (53%)
FERM_F1_TLN 88..205 CDD:340610 65/116 (56%)
B41 89..322 CDD:214604 147/232 (63%)
FERM_C_Talin 318..409 CDD:269973 66/90 (73%)
Talin_middle 510..668 CDD:462691 60/160 (38%)
ILWEQ 622..>768 CDD:214607 73/147 (50%)
Vinculin <874..>1035 CDD:460040 76/161 (47%)
talin-RS 1661..1832 CDD:213393 59/171 (35%)
VBS 1859..1982 CDD:430312 50/124 (40%)
I_LWEQ 2392..2533 CDD:460265 84/142 (59%)

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