DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLN1 and end4

DIOPT Version :10

Sequence 1:NP_006280.3 Gene:TLN1 / 7094 HGNCID:11845 Length:2541 Species:Homo sapiens
Sequence 2:NP_594069.2 Gene:end4 / 2543336 PomBaseID:SPAC688.11 Length:1102 Species:Schizosaccharomyces pombe


Alignment Length:1103 Identity:240/1103 - (21%)
Similarity:403/1103 - (36%) Gaps:274/1103 - (24%)


- Green bases have known domain annotations that are detailed below.


Human  1507 NSCRLASARTTNPTAKR-----QFVQSAKEVANSTANLVKTIKALDGAFTEENR------AQC-- 1558
            |.||:|:   ..|..:.     :|:.|......||.:..:|::.|...:..::.      |.|  
pombe   190 NECRIAA---LVPLVQESYGIYRFLTSMLRALYSTVDAPETLEPLKHRYKSQHHRLRQFYADCSN 251

Human  1559 -RAATA-----------PLLEAVDNLSAFASNPEFSSIPAQISPE--GRAAMEPIVISAKTMLES 1609
             |..|:           |.||..||:      |:....||.|:|:  |.:.:.|           
pombe   252 LRYLTSLISVPRLPHDPPDLEGDDNI------PDLPKRPASIAPQPTGASTIAP----------- 299

Human  1610 AGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRD 1674
                    :....:|..|                ::.......|..|...|.|..          
pombe   300 --------QPTGTSPSPP----------------VEMNFPDTSDITPAYSEPEPI---------- 330

Human  1675 LDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQLGHKVSQMAQYFE 1739
            .|..|...:.||||.::...|         |.|:.:.|      ||:..|:|.....:|.|...|
pombe   331 QDFWSDPTLDQQLAAQQAAQQ---------AAQQQAEL------AAQQAAAQQAQLAAQQAAEME 380

Human  1740 PLTLAAVGAASKTLSHPQ-----QMALLDQTKTLAESALQ---LLYTAKEAGGNPKQAAHTQEAL 1796
            ...:||       ..|.|     |||..:|.:...|...|   .:.|..:.....:|...|:..|
pombe   381 RQRMAA-------QQHQQALEAIQMAQAEQQRIAQEQLAQQQFQMQTQGQLAELEQQLLATRGQL 438

Human  1797 EEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRTA 1861
            |:: .::....:....||....|.|||      ::.:.|:|.|:                ::.:.
pombe   439 EQS-NVLLNQYDARVRTLENELSQAGV------NLQEQIHQNDD----------------LIESL 480

Human  1862 KAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGSHIKHRVQELGHG 1926
            |      .:::|..| ..|.|..|..||..::..|.|:.|...:.|.:.:.....|.:::.    
pombe   481 K------NQILTWKN-KYEALAKLYTQLRQEHLDLLSKYKQIQLKASSAQEAIDKKEKMER---- 534

Human  1927 CAALVTKAGALQCSPSDAYTKKELIECARRVSE--KVSHVLAALQAGNRGTQACITAASAVSGII 1989
                              ..|.:.:|.|..:.|  :..|.|..:....|..|             
pombe   535 ------------------EMKNKNLELADMILERDRARHELETMHRSQRDKQ------------- 568

Human  1990 ADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVAT 2054
                             |.||          :..::|.|....|.:|.:.....|.....:.||.
pombe   569 -----------------ESTE----------RELRLLQEKAASLERNKSSEVSNLLSRYNTEVAH 606

Human  2055 ITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQL----- 2114
            :...........|:||.|...|:    |..:.:.:...:.:...|||.     |.::.||     
pombe   607 LEDALHSKDRELANLGVELKSTE----NRYRQLLQEKEEELEIQKAAV-----DESLLQLSKLQL 662

Human  2115 -KNSA-KVMVTNVTSLLKTV-----KAVEDEATKGTRALEATTEHIRQELAV---FCSPEPPAKT 2169
             :|.. :.|.|.:..|||:.     ..|:.....|.:.|:.:...:...:..   :.:||  ...
pombe   663 DRNDIDQAMDTQIDELLKSQLEKLDDIVDSV
LATGIQRLDTSLYELDSPMHAGNQYATPE--FIL 725

Human  2170 STPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACK--EAAYHPEVAPDV 2232
            ||.|:........:.|.....|.|.:....:||...||...||.::....|  ......:...| 
pombe   726 STIENASNNATDFSTAFNNYFADGPNADHSEVINGVNLFSTAIYEVANNAKGLSRTTGDDQGSD- 789

Human  2233 RLRALHYGRECANGYLELLDHVL-LTLQKPSPELK---------------QQLTGHSKRVAGSVT 2281
              |.:...|:..|.....|..:. :..:|....:|               ||||.:|::.     
pombe   790 --RFVGLSRDLVNMAKRFLSSLFSVNTRKMDVNVKTDLVIGENIELQRYLQQLTQYSEKF----- 847

Human  2282 ELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKE---ADESLNFEE 2343
             |.:.:|...|......|:...:.:|:|...|.||:.|..:|:.:  .||||:   :...|...:
pombe   848 -LNKESENTVGLLNAPGENIEELVDNQLAETAQAIQQAILRLQNI--AAKPKDDSLSPSELQVHD 909

Human  2344 QILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANAL--DDGQWSQGLISAARMVAAATNN 2406
            .:|.|:.:|..|.:.|:|||:|:|.|:||||: |:....|.  ...:|::||||||:.||.||..
pombe   910 SLLSASIAITEAIARLIKAATASQAEIVAQGR-GSSSRGAFYKKHNRWTEGLISAAKAVARATTT 973

Human  2407 LCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLV 2471
            |.|.|:..|.|.:|.|.||.:...|:|:||||:.|.:|||:..|:....|:.|..||..|...||
pombe   974 LIETADGVVNGTSSFEHLIVACNGVSAATAQLVAASRVKANFASKVQDHLEDAAKAVTEACKALV 1038

Human  2472 K----AAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQY 2530
            :    .|.||...:.::..::.|.|.....|.|    |.::|:.|.:|..||::|..:|:..|
pombe  1039 RQVESVALKAKEVQHEDFSSLGVHEYRRKEIEQ----QVQILKLENDLVAARRRLFDMRKTSY 1097

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLN1NP_006280.3 FERM_F0_TLN1 2..85 CDD:340691
FERM_F1_TLN1 86..197 CDD:340693
B41 88..313 CDD:214604
Interaction with LAYN. /evidence=ECO:0000250|UniProtKB:P54939 280..435
FERM_C_Talin 309..400 CDD:269973
Helical bundle R1. /evidence=ECO:0000250|UniProtKB:P26039 482..655
Talin_middle 491..652 CDD:462691
ILWEQ 607..>759 CDD:214607
Helical bundle R2. /evidence=ECO:0000250|UniProtKB:P26039 656..786
Helical bundle R3. /evidence=ECO:0000250|UniProtKB:P26039 787..911
Helical bundle R4. /evidence=ECO:0000250|UniProtKB:P26039 913..1044
talin-RS 1043..1197 CDD:213393
Helical bundle R5. /evidence=ECO:0000250|UniProtKB:P26039 1046..1206
talin-RS 1204..1351 CDD:213393
Helical bundle R6. /evidence=ECO:0000250|UniProtKB:P26039 1207..1357
Interaction with SYNM. /evidence=ECO:0000269|PubMed:18342854 1327..1948 87/475 (18%)
Helical bundle R7A. /evidence=ECO:0000250|UniProtKB:P26039 1358..1453
Interaction with VCL and F-actin. /evidence=ECO:0000250|UniProtKB:P26039 1359..1659 31/178 (17%)
Helical bundle R8. /evidence=ECO:0000250|UniProtKB:P26039 1461..1580 20/97 (21%)
Helical bundle R7B. /evidence=ECO:0000250|UniProtKB:P26039 1581..1653 8/73 (11%)
talin-RS 1654..1826 CDD:213393 41/179 (23%)
Helical bundle R9. /evidence=ECO:0000250|UniProtKB:P26039 1655..1822 38/174 (22%)
Helical bundle R10. /evidence=ECO:0000250|UniProtKB:P26039 1823..1973 23/151 (15%)
VBS 1849..1973 CDD:430312 19/125 (15%)
Helical bundle R11. /evidence=ECO:0000250|UniProtKB:P26039 1974..2140 30/177 (17%)
Helical bundle R12. /evidence=ECO:0000250|UniProtKB:P26039 2141..2294 32/173 (18%)
Helical bundle R13. /evidence=ECO:0000250|UniProtKB:P26039 2300..2482 70/190 (37%)
ILWEQ 2336..2532 CDD:214607 72/201 (36%)
end4NP_594069.2 ANTH 16..271 CDD:400137 16/83 (19%)
DUF1373 259..>331 CDD:462093 18/122 (15%)
Smc <380..>693 CDD:440809 75/420 (18%)
ILWEQ 902..1100 CDD:214607 72/201 (36%)
Blue background indicates that the domain is not in the aligned region.

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