DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLL2 and tok

DIOPT Version :10

Sequence 1:NP_036597.1 Gene:TLL2 / 7093 HGNCID:11844 Length:1015 Species:Homo sapiens
Sequence 2:NP_476879.1 Gene:tok / 42944 FlyBaseID:FBgn0004885 Length:1464 Species:Drosophila melanogaster


Alignment Length:938 Identity:477/938 - (50%)
Similarity:630/938 - (67%) Gaps:37/938 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    85 KQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAGKDGRENTTLLHSPGTLHAAAKTFSPRVRR 149
            :.|.....||..|..:...........||....|..||   ...|.|              ||.|
  Fly   472 QSTTQYVNHSPPGFNQSQQAQQQSVPEMDLLKAETSKD---EEPLRH--------------RVAR 519

Human   150 ATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDE--ESFIVFSYRTC 212
            |.|::.||||..|||||.|.|||:|..:|:||.||||||..||:.|:||..|  .::|||:.|:|
  Fly   520 AVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSC 584

Human   213 GCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYN 277
            ||||:||:||.||||||||:||||||||.||||||||||||||||||::||.|...||..||:||
  Fly   585 GCCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKGQDYN 649

Human   278 FLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQA 342
            |..:...||.|||..||:||||||||||||:|.:||||||.:.....||.||||:||||||||||
  Fly   650 FNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLRLSQGDIAQA 714

Human   343 RKLYKCPACGETLQDTTGNFSAPG-FPNGYPS--YSHCVWRISVTPGEKIVLNFTSMDLFKSRLC 404
            ..|||||.||.|.|:::|.|::|. :..|..|  ..||.|||:.|.||::.|...:|::|||..|
  Fly   715 NLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETEHCEWRITATYGERVELKLENMNIFKSNNC 779

Human   405 WYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTD-SRLWVEFRSSSNILG-KGFFAAYEATCGGD 467
            ..||:|:||||:.|:||:||||| |:.:.::.|: ||:.:.:.::..|.| :||.|.::..|||:
  Fly   780 ETDYLEIRDGYFEKSPLIGRFCG-KVDKEVIRTESSRMLLTYVNTHRIEGFRGFKAEFDVVCGGE 843

Human   468 MNKD--AGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTE 530
            ::.|  .|:::|||||.||.|:|||||:|||.|.:.|.|.||:||:|.||||.|||:||||||.:
  Fly   844 LSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQSFEVENHDSCVYDYVEVRDGPGQ 908

Human   531 ESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNT 595
            ::.|||.||||:.|.::|||.|.:::|||||.|:.||||:|.|.||||||...:| ||||.|:||
  Fly   909 DAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKAGFSAVFMKEVDECETQNH-GCEHECINT 972

Human   596 LGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISL 660
            ||.|:|:|..|:||.:|||.||.||||.|...|||||||.:|:.||..|.|:|::|||.::||||
  Fly   973 LGGYECSCRIGFELHSDKKHCEDACGGVIEYPNGTITSPSFPEMYPLLKECIWEIVAPPKHRISL 1037

Human   661 QFEVFELEG----NDVCKYDFVEVRSGLSPD-AKLHGRFCGSETPEVITSQSNNMRVEFKSDNTV 720
            .|..|:|||    ...|.||.|.|.|.|..: .|..|.||||..|...||:||.:|:||.||.::
  Fly  1038 NFTHFDLEGTAHQQSDCGYDSVTVYSKLGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSI 1102

Human   721 SKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEG 785
            .:.||.|.||:|.||||.:||||||||.||.|||:|.|.|||.:|||||||||..|.::||:..|
  Fly  1103 QRSGFAAVFFTDIDECAVNNGGCQHECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEISAPFG 1167

Human   786 TLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRF 850
            |:.|||:||.||...:|.|:..:|.|||:||.||||::|.||||.||::.:|||....:.:||||
  Fly  1168 TIFSPNYPDSYPPNADCVWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRF 1232

Human   851 CGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPS 915
            ||.|.|.|..::.:.|::...:|.:.|:.||.|.|||.|||.|:|..|.::.||||:||:.:|..
  Fly  1233 CGDKIPFPISSTSNQMYMVLKTDKNKQKNGFTASHSTACGGYLRATSQVQQFYSHARFGNQDYDD 1297

Human   916 EARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAY----DGYDSSAPRLGRFCGSGPLEEI 976
            ...|:|.|.|.|...|:|.|.||::|...:|.:||::.:    |.|....|..|::||:...::|
  Fly  1298 GMDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQDI 1362

Human   977 YSAGDSLMIRFRTDDTINKKGFHARYTS 1004
            .|...||::||:||.::..|||.|.|.:
  Fly  1363 NSMTHSLLVRFKTDGSVPMKGFSASYVA 1390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLL2NP_036597.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..49
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 88..130 8/41 (20%)
ZnMc_BMP1_TLD 150..349 CDD:239808 133/200 (67%)
CUB 351..460 CDD:395345 47/113 (42%)
CUB 464..573 CDD:395345 65/110 (59%)
FXa_inhibition 580..616 CDD:464251 20/35 (57%)
CUB 620..729 CDD:395345 55/113 (49%)
FXa_inhibition 736..771 CDD:464251 25/34 (74%)
CUB 776..885 CDD:395345 49/108 (45%)
CUB 889..1002 CDD:395345 45/116 (39%)
tokNP_476879.1 ZnMc_BMP1_TLD 520..721 CDD:239808 133/200 (67%)
CUB 723..836 CDD:412131 47/113 (42%)
CUB 840..951 CDD:395345 65/110 (59%)
FXa_inhibition 958..993 CDD:464251 20/35 (57%)
CUB 997..1111 CDD:395345 55/113 (49%)
FXa_inhibition 1118..1153 CDD:464251 25/34 (74%)
CUB 1158..1267 CDD:395345 49/108 (45%)
CUB 1271..1390 CDD:238001 46/118 (39%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.