DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TLL2 and CG15253

DIOPT Version :9

Sequence 1:	NP_036597.1	Gene:	TLL2 / 7093	HGNCID:	11844	Length:	1015	Species:	Homo sapiens
Sequence 2:	NP_609758.1	Gene:	CG15253 / 34916	FlyBaseID:	FBgn0028948	Length:	253	Species:	Drosophila melanogaster

Alignment Length:	215	Identity:	74/215 - (34%)
Similarity:	105/215 - (48%)	Gaps:	12/215 - (5%)

- Green bases have known domain annotations that are detailed below.

Human   144 SPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIE-RTDEESFIVF 207
            |..:.|..|.|    ||..:|.|.|........|.....|::..|..:|:||.| .||::.::..
  Fly    46 SRNIWRNETYR----WPNRIIYYHINSYIDEEHRNHIVSAIQKIESISCLTFKEATTDQKYYVNV 106

Human   208 SYRTCGCCSYVGRRGG----GPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRE 268
            :....||.||:|....    ..|...||..|.:...:.||..|.:||:|:.:..|||.:|.|:.|
  Fly   107 TSEEGGCFSYIGYLNRVQQLNLQNNEIGVGCFRLYTIVHEFLHALGFFHQQSAADRDDYVQIVEE 171

Human   269 NIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVR 333
            ||..|.|:||.|.....|:..||.||:.|:|||....||:. ...|||..::  |....||||:.
  Fly   172 NITEGMEFNFDKYTEETVNDFGEKYDYGSVMHYGPYAFSKN-GERTILALEE--GKEDVIGQRLE 233

Human   334 LSQGDIAQARKLYKCPACGE 353
            ||:.||.:...:||||...|
  Fly   234 LSETDIRKLNAIYKCPTVKE 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TLL2	NP_036597.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	88..130
		ZnMc_BMP1_TLD	150..349	CDD:239808	69/203 (34%)
		Astacin	157..350	CDD:279708	68/197 (35%)
		CUB	351..460	CDD:278839	1/3 (33%)
		CUB	464..573	CDD:278839
		FXa_inhibition	584..616	CDD:291342
		CUB	620..729	CDD:278839
		FXa_inhibition	736..771	CDD:291342
		CUB	776..885	CDD:278839
		CUB	889..1002	CDD:278839
CG15253	NP_609758.1	Astacin	55..250	CDD:279708	69/201 (34%)
CG15253	NP_609758.1	ZnMc_astacin_like	59..246	CDD:239807	63/189 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810