DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TLL2 and Cubn

DIOPT Version :9

Sequence 1:	NP_036597.1	Gene:	TLL2 / 7093	HGNCID:	11844	Length:	1015	Species:	Homo sapiens
Sequence 2:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster

Alignment Length:	1030	Identity:	244/1030 - (23%)
Similarity:	389/1030 - (37%)	Gaps:	291/1030 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   147 VRRATTSRTERIWPGGV-----IPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIV 206
            :..::|:.||   ||||     |...:|      ::.:.:.|....:...|:..::.|||...|:
  Fly   755 ISESSTANTE---PGGVSCEYEIHLAVG------EQVVIQFARLELDPLDCLEVLDITDEGGSIL 810

Human   207 FSYRTCGC----------CSYVGR-------RGGGPQAISIGKNCD-KFGIVAHELGHVVGFWHE 253
             ..:.||.          .|...|       |.|..| ::....|| |..   :|.|.:....:.
  Fly   811 -QEKICGSDASRLNPPTFTSEFNRLKIKFYARAGSFQ-LNYRMACDYKLN---NEQGTITSPGYP 870

Human   254 H-TRPDR------------------------------DQHVTIIRENI----------------- 270
            : ||.||                              |.:...:..|:
  Fly   871 NLTRSDRICTYTISTATNTVISLKRIDFQLTNGESDDDDNDECLTTNLRINDGLNRKILGPYCGK 935

Human   271 -QPGQ----EYNFLKME-AGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDD--NGVRPT 327
             ||.:    |.|:|::. :.:|.|:|..:.|:.                ..|...:|  .||...
  Fly   936 NQPEENFVSETNYLQLHLSTDVDSMGRGFKFEY----------------RALATGNDKCGGVHTR 984

Human   328 IGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLN 392
            .|..:||                              |...:.|...:.|.|.|.....:.|.|:
  Fly   985 SGDHIRL------------------------------PVHDDSYAGEATCYWVIMAPANKAIRLH 1019

Human   393 FTSMDLFKSRLCWYDYVEVRDGYW------RKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNI 451
            :.|..|..:..|.|||:|:.|...      |..| |.::||:.:||.|:|...:|.::|.|..:.
  Fly  1020 WNSFSLENAVDCIYDYLEIYDSLGAQVNDERSKP-LAKYCGNSVPEDLLSHSRQLVLKFVSDYSE 1083

Human   452 LGKGFFAAY----EATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIE 512
            ...||...|    .|.|||.::..:|::.||.||.:|....:|.|.:|.:....:.:..:.||:|
  Fly  1084 SDGGFDLTYTFEDRAKCGGHIHASSGELTSPEYPANYSAGLDCDWHLTGTIDHLLEIQVENFELE 1148

Human   513 RHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEV 577
            :..:|:.||||||:|...:|.|||.|||.:.|..:...|:.:.:...:|.:||..||
  Fly  1149 QSPNCSADYLEVRNGGGTDSPLIGRFCGRDIPARIPGFSHEMRLILHTDSAINGRGF-------- 1205

Human   578 DECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPT 642
             ...|                               ::....|||.:....|.|:||.:|..||.
  Fly  1206 -RLRW-------------------------------RIFAFGCGGSLRSNMGAISSPRYPNSYPN 1238

Human   643 NKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGL-----SP------DAKLHGRFCG 696
            ..:|.|::.......|||..|..||||...|.||.|::.:|:     ||      |..||.
  Fly  1239 MAHCEWRISLHPGSGISLLIEDLELEGLSNCYYDSVKIYTGIKLPNQSPCKVLCKDDDLHN---- 1299

Human   697 SETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKD----NG---------------- 741
                .:|..::|...:.|.||.:.:.||||   .|.|..|.::    .|
  Fly  1300 ----PLIQLENNKGTIVFDSDASNTFRGFR---ISYKANCIRNLTATTGTIESLNYMEPFWETIP 1357

Human   742 -GC-----------------------QHECVNTF--GSYLCRCRN-------------GYWL--- 764
             .|                       ||....|.  |.|:...||             |..|
  Fly  1358 INCSWTIRAPKGNRVLVEVSHLARHEQHVPTATMPGGLYIVDGRNVQEIVTPQAMNISGEVLTVV 1422

Human   765 HENGH-----DCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIE 824
            |...:     |.:..||..::....|...|||:|..||:..||.|.|:......::||.|..::|
  Fly  1423 HNASNVNFQLDYRIDGCMEELRGTFGFFQSPNYPKMYPNNLECYWLITVEQDSAIELTINNIDLE 1487

Human   825 QHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHST-- 887
            ....|..|.|.:.:..:|: .:..|.|||.......:||..:.:||.||.|....||:|.:.|
  Fly  1488 DSPNCTKDALTVSNHKNSV-EVHERHCGSTTKLVITSSGHRLHVRFISDNSHNGLGFEATYRTVK 1551

Human   888 -ECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYM 951
             .|||:|.|.....|..::..    |||:.:||:|.:.....:.:........:|...||.:||:
  Fly  1552 ATCGGKLTARNGVIESPNYPL----NYPAHSRCEWQVEVSQHHQIVFEMADLNLESGYDCNWDYL 1612

Human   952 EAYD--GYDSSAPRLGRFCGSGPLEE--IYSAGDSLMIRFRTDDTINKKGFHARY 1002
            ||||  ..|:...||.:.||....::  :.|:.:..::||.:||:::||||...:
  Fly  1613 EAYDLTEDDTEGERLFKVCGDETEDDKLLSSSSNMAVVRFISDDSVSKKGFRLHF 1667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TLL2	NP_036597.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	88..130
		ZnMc_BMP1_TLD	150..349	CDD:239808	49/277 (18%)
		Astacin	157..350	CDD:279708	46/271 (17%)
		CUB	351..460	CDD:278839	29/114 (25%)
		CUB	464..573	CDD:278839	37/108 (34%)
		FXa_inhibition	584..616	CDD:291342	0/31 (0%)
		CUB	620..729	CDD:278839	39/119 (33%)
		FXa_inhibition	736..771	CDD:291342	13/101 (13%)
		CUB	776..885	CDD:278839	34/108 (31%)
		CUB	889..1002	CDD:278839	35/116 (30%)
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	282..322	CDD:214542
		EGF_3	328..366	CDD:289699
		EGF	430..457	CDD:278437
		EGF_CA	469..503	CDD:238011
		CUB	509..622	CDD:238001
		CUB	627..737	CDD:238001
		CUB	744..849	CDD:294042	22/104 (21%)
		CUB	853..970	CDD:238001	20/135 (15%)
		CUB	978..1094	CDD:238001	35/146 (24%)
		CUB	1100..1211	CDD:238001	38/150 (25%)
		CUB	1216..1330	CDD:238001	40/124 (32%)
		CUB	1446..1549	CDD:238001	33/103 (32%)
		CUB	1554..1667	CDD:238001	35/116 (30%)
		CUB	1792..1899	CDD:238001
		CUB	1910..1998	CDD:294042
		CUB	2019..2133	CDD:238001
		CUB	2140..2242	CDD:238001
		CUB	2263..2379	CDD:238001
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:294042
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001
		CUB	3254..3363	CDD:238001
		CUB	3379..3508	CDD:238001
		CUB	3531..3601	CDD:294042
		CUB	3623..3733	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910