DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLL1 and Cubn

DIOPT Version :9

Sequence 1:NP_036596.3 Gene:TLL1 / 7092 HGNCID:11843 Length:1013 Species:Homo sapiens
Sequence 2:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster


Alignment Length:1021 Identity:240/1021 - (23%)
Similarity:389/1021 - (38%) Gaps:280/1021 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   130 GKVPLQFSGQNEK-NRVPR---AATSRTERIWPGGVIP-------YVIGGNFTGSQRAMFKQAMR 183
            |:.|:.::|...| .|.|:   ....:|.|..|.|..|       ::|.|  |.|.|........
  Fly   353 GECPVGWTGDGRKCERSPQDIDIPAGQTPRTCPAGNNPCYPTASCFLISG--TTSCRCPMGMVGT 415

Human   184 HWEKHTCVTFIERSDEESYIVFTYRPC---GCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHV 245
            .:..:.||.....:.:|:       ||   |.|.:.     ||...:.  .|.            
  Fly   416 GYGPNGCVNGTTTNCKEN-------PCLNGGICLFA-----GPSNYTC--LCP------------ 454

Human   246 IGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFL 310
            |||     ||      .|......|..::....         |.|         .|.|.|..:|:
  Fly   455 IGF-----RP------PICEPQPSPCDQHPCKN---------GGR---------CRPTTSGDLFV 490

Human   311 DTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHC 375
            ...||           |.|.||.:         .|..:|...|...:|.|..|....||.....|
  Fly   491 CQCLP-----------GYRGRLCE---------TRFSSCNGMLSAQSGRLRYPPEGTGYEHNAQC 535

Human   376 IWRVSVTPGEKIVLN--FTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPE--VLTSTD 436
            .|  .:...|.:|:|  |.:.|:..|:.|.:|::::.||....:.::||:||:.||.  .:.|:.
  Fly   536 AW--VIRTNESLVVNVTFNSFDVEDSTECRFDWLQINDGRSAAAQIIGRYCGNHLPHGGNIVSSG 598

Human   437 SRMWIEFRSSSNWVGKGFAAVYEAI---CGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSES 497
            :::::.|||.::...:||...:.::   |||.:. :..|.:.||..|.:|...::|.|::....:
  Fly   599 NQLYLWFRSDNSTAKEGFDLTWNSMEPQCGGRLNFETHGTLASPGSPGNYPKNRDCRWQLVAPTT 663

Human   498 YHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTV 562
            ..:.|||.|.::|:|.||.:||:.::|..|...  :.::|....|..:...::...:.|.||...
  Fly   664 KRIKLTFFSLQLEQHANCNFDYVLIKDSISGRE--LAKYCTTGAPAPLLLPTHLAEIHFHSDAEG 726

Human   563 NKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCA-CEPG-----YE--------------- 606
            :..||..::..||   ..|..||.......|:.....| .|||     ||               
  Fly   727 SDTGFQLHYSVEE---RVPGCGGVYTAKEGTISESSTANTEPGGVSCEYEIHLAVGEQVVIQFAR 788

Human   607 LGPDRRSC---------------EAACGGLLTKLN------------------------------ 626
            |..|...|               |..||...::||                              
  Fly   789 LELDPLDCLEVLDITDEGGSILQEKICGSDASRLNPPTFTSEFNRLKIKFYARAGSFQLNYRMAC 853

Human   627 --------GTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFEL-------EGNEVCKYDYV 676
                    ||||:||:|.....::.|.:.:...|...||:|...|:|       :.|:.|....:
  Fly   854 DYKLNNEQGTITSPGYPNLTRSDRICTYTISTATNTVISLKRIDFQLTNGESDDDDNDECLTTNL 918

Human   677 EIWSGLSSESKLHGKFCGAEVPEV-ITSQFNNMRIEFKSDNTVSKKGFKAHF---FSDKDECSKD 737
            .|..||:  .|:.|.:||...||. ..|:.|.:::...:|.....:|||..:   .:..|:|   
  Fly   919 RINDGLN--RKILGPYCGKNQPEENFVSETNYLQLHLSTDVDSMGRGFKFEYRALATGNDKC--- 978

Human   738 NGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSG-LITSPNWPDKYPSRKECT 801
             ||                                     :|:.|| .|..|...|.|.....|.
  Fly   979 -GG-------------------------------------VHTRSGDHIRLPVHDDSYAGEATCY 1005

Human   802 WEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDG-----ETEKSPILGRLCGNKIPDPLVATG 861
            |.|.|.....|:|.::.|.:|...:|.||:||::|.     ..|:|..|.:.|||.:|:.|::..
  Fly  1006 WVIMAPANKAIRLHWNSFSLENAVDCIYDYLEIYDSLGAQVNDERSKPLAKYCGNSVPEDLLSHS 1070

Human   862 NKMFVRFVSDASVQRKGFQATHSTE----CGGRLKAESKPRDLYSHAQFGD-------NNYPGQV 915
            .::.::||||.|....||..|::.|    |||.:           ||..|:       .||...:
  Fly  1071 RQLVLKFVSDYSESDGGFDLTYTFEDRAKCGGHI-----------HASSGELTSPEYPANYSAGL 1124

Human   916 DCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDS 980
            ||:|.|.......||:..:.||:|:..:|..||:|:.:|..:.:..:|||||...|..|......
  Fly  1125 DCDWHLTGTIDHLLEIQVENFELEQSPNCSADYLEVRNGGGTDSPLIGRFCGRDIPARIPGFSHE 1189

Human   981 VLIHFHTDDTINKKGFHIRYK------------------SIRYPDT 1008
            :.:..|||..||.:||.:|::                  |.|||::
  Fly  1190 MRLILHTDSAINGRGFRLRWRIFAFGCGGSLRSNMGAISSPRYPNS 1235

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLL1NP_036596.3 ZnMc_BMP1_TLD 148..347 CDD:239808 40/208 (19%)
Astacin 155..348 CDD:279708 39/202 (19%)
CUB 349..458 CDD:278839 31/112 (28%)
CUB 462..571 CDD:278839 29/109 (27%)
FXa_inhibition 582..614 CDD:291342 11/52 (21%)
CUB 618..727 CDD:278839 35/154 (23%)
FXa_inhibition 734..769 CDD:291342 3/34 (9%)
CUB 774..883 CDD:278839 36/114 (32%)
CUB 887..1000 CDD:278839 36/119 (30%)
CubnNP_727348.2 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_3 328..366 CDD:289699 3/12 (25%)
EGF 430..457 CDD:278437 9/52 (17%)
EGF_CA 469..503 CDD:238011 12/62 (19%)
CUB 509..622 CDD:238001 31/114 (27%)
CUB 627..737 CDD:238001 29/111 (26%)
CUB 744..849 CDD:294042 17/104 (16%)
CUB 853..970 CDD:238001 31/118 (26%)
CUB 978..1094 CDD:238001 40/156 (26%)
CUB 1100..1211 CDD:238001 37/121 (31%)
CUB 1216..1330 CDD:238001 4/20 (20%)
CUB 1446..1549 CDD:238001
CUB 1554..1667 CDD:238001
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:294042
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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