DRSC/TRiP Functional Genomics Resources

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Protein Alignment TLE1 and gro

DIOPT Version :10

Sequence 1:XP_005252208.1 Gene:TLE1 / 7088 HGNCID:11837 Length:814 Species:Homo sapiens
Sequence 2:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster


Alignment Length:851 Identity:492/851 - (57%)
Similarity:568/851 - (66%) Gaps:158/851 - (18%)


- Green bases have known domain annotations that are detailed below.


Human     1 MFPQSRHPTPHQAAG-----QPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60
            |:|.   |..|.|||     .|.||||.::|:||||||.||||||||:|||||||::||||||||
  Fly     1 MYPS---PVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRH 62

Human    61 YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGV 125
            ||||||||||||:||||||||||||||:..|::|||..:|||||.|||||||||||.|||.|||.
  Fly    63 YVMYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGH 127

Human   126 RGLPGLPPTQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIK 190
            :...|:....||:.||.:.  .|||.|:    ..|.|.|  .||.:.||      ..|...|..|
  Fly   128 QQQHGIQQLLQQIHAQQVP--GGPPQPM----GALNPFG--ALGATMGL------PHGPQGLLNK 178

Human   191 DDKKHHDAEHHR-DREP-GTSNSLLVPDSLRGT----DK---RRNGP-EFSNDIKKRKVDDKDSS 245
                  ..|||| |.:| |........:.||.:    |:   |...| :..||.|:|    ||..
  Fly   179 ------PPEHHRPDIKPTGLEGPAAAEERLRNSVSPADREKYRTRSPLDIENDSKRR----KDEK 233

Human   246 HYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENG------------IDKNRL-------LKK 291
            ..:.:|:|||.:|||||:||..|       ||||.||            ::..||       :|:
  Fly   234 LQEDEGEKSDQDLVVDVANEMES-------HSPRPNGEHVSMEVRDRESLNGERLEKPSSSGIKQ 291

Human   292 DASSSPASTASSASSTSLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPA 356
            :...|.:.::||.|:.|||:|:|   ||..||..|:.||||.:..|.||                
  Fly   292 ERPPSRSGSSSSRSTPSLKTKDM---EKPGTPGAKARTPTPNAAAPAPG---------------- 337

Human   357 IDPLVNQAGLDFHLELVPGNGKFGLKEKSWILSRKSSFEIKSAAGLRTPLAVPGPYPAPFGMVPH 421
            ::|          .:::|                                  .||.||.:     
  Fly   338 VNP----------KQMMP----------------------------------QGPPPAGY----- 353

Human   422 AGMNGELTSPGAAY---ASLHNMSPQMSAAAAAAAVVAYGRSPMVGFDPPPHMRVPTIPPNLAGI 483
                     |||.|   |..:...|         :..||||.|.:.:||..|:|...| |:.:.:
  Fly   354 ---------PGAPYQRPADPYQRPP---------SDPAYGRPPPMPYDPHAHVRTNGI-PHPSAL 399

Human   484 PGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGK 548
            .|||||||||:..:|.:||||||||||:|.||||||||||||:||||||||||||||::||||||
  Fly   400 TGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGK 464

Human   549 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAE 613
            |||||||||.||||:||||||||.|||||||.||||||.|||||||||.|||||||:||||||||
  Fly   465 GCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAE 529

Human   614 LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTG 678
            |||:||||||||||||||||||||||||||||||||:.||||||||||||||||||.||::||||
  Fly   530 LTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTG 594

Human   679 GLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHES 743
            ||||||||||||||||||||||:||||||||||||:|||||||:|:|||||.:||||||||||||
  Fly   595 GLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHES 659

Human   744 CVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKAT 808
            |||||:||.||||||||||||||||||||||||||||||:|||||||||.|||||||||||||||
  Fly   660 CVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDISTDDKYIVTGSGDKKAT 724

Human   809 VYEVIY 814
            ||||||
  Fly   725 VYEVIY 730

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLE1XP_005252208.1 TLE_N 18..143 CDD:461094 91/124 (73%)
WD40 527..812 CDD:441893 259/284 (91%)
WD40 repeat 531..570 CDD:293791 34/38 (89%)
WD40 repeat 578..616 CDD:293791 33/37 (89%)
WD40 repeat 621..657 CDD:293791 33/35 (94%)
WD40 repeat 664..699 CDD:293791 31/34 (91%)
WD40 repeat 704..737 CDD:293791 27/32 (84%)
WD40 repeat 745..779 CDD:293791 31/33 (94%)
WD40 repeat 786..810 CDD:293791 22/23 (96%)
groNP_996298.1 TLE_N 20..124 CDD:461094 83/103 (81%)
WD40 <443..728 CDD:441893 259/284 (91%)
WD40 repeat 447..486 CDD:293791 34/38 (89%)
WD40 repeat 494..532 CDD:293791 33/37 (89%)
WD40 repeat 537..573 CDD:293791 33/35 (94%)
WD40 repeat 580..615 CDD:293791 31/34 (91%)
WD40 repeat 620..653 CDD:293791 27/32 (84%)
WD40 repeat 661..695 CDD:293791 31/33 (94%)
WD40 repeat 702..726 CDD:293791 22/23 (96%)

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