DRSC/TRiP Functional Genomics Resources

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Protein Alignment ICAM5 and side-VI

DIOPT Version :9

Sequence 1:NP_003250.3 Gene:ICAM5 / 7087 HGNCID:5348 Length:924 Species:Homo sapiens
Sequence 2:NP_001036705.1 Gene:side-VI / 4379854 FlyBaseID:FBgn0083950 Length:1087 Species:Drosophila melanogaster


Alignment Length:621 Identity:139/621 - (22%)
Similarity:203/621 - (32%) Gaps:201/621 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   390 DGETL--IKNRSAEL-----------RVL-------------YAPRLDDSDCPRSWTWPEGPEQT 428
            |||.|  :.|.||::           :||             |..|...:..|..|...|..|. 
  Fly    31 DGEILRVLVNSSAQIKCDVGSSQADDKVLLVVWYKNNLPIYSYDTRGAHAGTPSHWRDEEVLED- 94

Human   429 LRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKA---------ANDQGEAVKDVT 484
             |...|.:.||             |..::.||....:|.:||:.         :|...|.|...|
  Fly    95 -RAVFRTHKEP-------------AELIINPVKEKDAGNFRCRVDFKLSQTRNSNVNLEVVVPPT 145

Human   485 LTV---EYAPALDSVGCPERITWLEGTEASLSCVAH-GVPPPDVICVRSGEL----------GA- 534
            ..:   |....:||...|    :.||....::||.: |.|||.||.:.:|:|          || 
  Fly   146 QPIIFNERRLRIDSRAGP----YEEGGSLEVTCVVYGGSPPPTVIWLMNGQLQNSVVDYTYDGAI 206

Human   535 ----VIEGLLRVAREHAGTYRCEATN-PRGSAAKNVAVTVEYGP---------------RFEEPS 579
                |:..|.|: .:|| .|.|:|:| .:...|.|:.:.:...|               |..|..
  Fly   207 NSKLVVRNLSRI-HQHA-VYTCQASNFHKKYVATNITIDLYLRPLLVEISFNNQPMSADRKYEIE 269

Human   580 C-------PSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRV 637
            |       |:..||..|     :.|:.|..|   |....|..:..||      ..:|......:.
  Fly   270 CQAIGSRPPAKITWWMG-----NLELHGHSQ---KVSEDGNVSTSVL------SITPTREDHGKA 320

Human   638 LAPGIYVCNATN---RHGSVAKTVVV--------------SAESPPEMDES-----TCPSHQ--- 677
            |:     |.|||   |:| :.:|.:.              |..:|.:::|.     .|..|.   
  Fly   321 LS-----CRATNELVRNG-IRETAMKLNVFFIPTLQLDLGSNLNPEDIEEGDDVYFECKVHANPA 379

Human   678 ----TWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVSREDAGTYHCVATNAHGT-DSRT 737
                .|....:      ..:.....||..|...:   ..|.|:|..||.|.|.|:|..|. ||..
  Fly   380 AYKVVWKHNHQ------IIQHNQRAGVIVSSGDL---ALQGVTRHQAGNYTCTASNVEGDGDSNV 435

Human   738 VTVGVEYRPVVAELAASPPG----GVRPGGNFTLTCRAEAWPPAQ-ISWRAPPGALNIGL----- 792
            |.:.|.|:|:     ..|..    ||.......:.|..:|:||.: ..|.....|....:     
  Fly   436 VELKVMYKPI-----CRPDQKKIYGVARNEAAEIVCEVDAFPPPENFKWSFNNTAETFDMPQSGF 495

Human   793 ---SSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLAAGA 854
               |:..|||:.........|...|.|.|..|:........                  |:|||.
  Fly   496 RPHSAQGSTLTYTPVKEMDFGTIMCWADNNVGQQKEPCVFH------------------LIAAGK 542

Human   855 GLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGG 890
            ..|    .|.|..    |.:...|.|..|:.|..||
  Fly   543 PEA----PTNCTV----VNQTSDSLEVYCIEGFDGG 570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ICAM5NP_003250.3 ICAM_N 31..103 CDD:252248
Ig2_ICAM-1_like 120..219 CDD:143232
Ig_2 325..404 CDD:290606 7/26 (27%)
IG_like 416..487 CDD:214653 18/79 (23%)
Ig 424..487 CDD:299845 15/71 (21%)
IG_like 499..569 CDD:214653 26/86 (30%)
Ig 512..570 CDD:299845 23/74 (31%)
Ig 594..652 CDD:299845 14/60 (23%)
Ig 693..742 CDD:299845 16/49 (33%)
IG_like <713..740 CDD:214653 13/27 (48%)
IG_like 759..831 CDD:214653 16/80 (20%)
IGc2 761..821 CDD:197706 14/68 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..911 139/621 (22%)
side-VINP_001036705.1 IG_like 35..140 CDD:214653 23/119 (19%)
Ig_3 157..230 CDD:290638 25/78 (32%)
IG_like 165..242 CDD:214653 25/78 (32%)
Ig 265..343 CDD:299845 22/97 (23%)
IG_like 267..343 CDD:214653 22/95 (23%)
IG_like 363..440 CDD:214653 20/85 (24%)
IGc2 364..429 CDD:197706 16/73 (22%)
IG_like 456..532 CDD:214653 16/75 (21%)
Ig_3 456..524 CDD:290638 14/67 (21%)
fn3 545..622 CDD:278470 10/34 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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