DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ICAM5 and Pxn

DIOPT Version :9

Sequence 1:	NP_003250.3	Gene:	ICAM5 / 7087	HGNCID:	5348	Length:	924	Species:	Homo sapiens
Sequence 2:	NP_523891.2	Gene:	Pxn / 38326	FlyBaseID:	FBgn0011828	Length:	1527	Species:	Drosophila melanogaster

Alignment Length:	658	Identity:	156/658 - (23%)
Similarity:	220/658 - (33%)	Gaps:	195/658 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   337 GQMVTVTCAAGAQALV-TLEGVPA---AVPGQP-----AQLQLNATE------------------ 374
            |.:.:|.|.||...|. |:..:.|   |||..|     ..|:.|..|
  Fly    19 GGVQSVYCPAGCTCLERTVRCIRAKLSAVPKLPQDTQTLDLRFNHIEELPANAFSGLAQLTTLFL 83

Human   375 NDDRRSFFCDATLDVDGETLIK------NRSAELRV--------LYAPRLDDSDCPRSWTWPEGP 425
            ||:..::..|..|  :|.|.::      ||.:.|..        |.|..|:::|.   |..|.|.
  Fly    84 NDNELAYLQDGAL--NGLTALRFVYLNNNRLSRLPATIFQRMPRLEAIFLENNDI---WQLPAGL 143

Human   426 EQTL--------------RCEARG-NPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRC--KAA 473
            ...|              :....| |...::...|.||.|:          ....|.|..  :..
  Fly   144 FDNLPRLNRLIMYNNKLTQLPVDGFNRLNNLKRLRLDGNAI----------DCNCGVYSLWRRWH 198

Human   474 NDQGEAVKDVTLTVEYAPALDSVG------------------CPERITWLEGTEASLSCVAHGVP 520
            .|....:..::||......|.:.|                  .|:......|.:..|||...|:|
  Fly   199 LDVQRQLVSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVELSCEVTGLP 263

Human   521 PPDVICV-RSGELGAVIEG----------LLRVA-REHAGTYRCEATNPRGS-AAKNVAVTVEYG 572
            .|.:..: .:.|||...:.          |:|.| ....|.|:|.|.|..|: .::.|.:.|..|
  Fly   264 RPQITWMHNTQELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQPVRLVVNGG 328

Human   573 --PRFEEPSCPSNWTWVE---------------------------------GSGR-LFSCEVDGK 601
              |........||..|.:                                 |||. |..|...|.
  Fly   329 NHPLDSPIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQPHDQIVALHGSGHVLLDCAASGW 393

Human   602 PQPSVKCVGSGG-----------ATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVA 655
            |||.::...:|.           ...|.|:.|.           |..|:.|.|.|.|.|..|||.
  Fly   394 PQPDIQWFVNGRQLLQSTPSLQLQANGSLILLQ-----------PNQLSAGTYRCEARNSLGSVQ 447

Human   656 KTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWP--------EQ 712
            .|..:..:..||:  .|.|..|| ::..:|..|.|.|.|.|.|.:.....|:|.|        |.
  Fly   448 ATARIELKELPEI--LTAPQSQT-IKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQLEN 509

Human   713 QRVS-------REDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVR-PGGNFTLTC 769
            :...       :|.||.|.|.|.|.:|..|...|:.||......:||..|...|. .|....|.|
  Fly   510 ENTELVVGAARQEHAGVYRCTAHNENGETSVEATIKVERSQSPPQLAIEPSNLVAITGTTIELPC 574

Human   770 RAEAWPP--AQISWRAPPGAL---NIGLS-----SNNSTLSVAGAMGSHGGEYECAATNAHGRHA 824
            :|:. |.  .||||| ..|.|   |:.|:     |...:|.|.......||.|||...|..||.:
  Fly   575 QADQ-PEDGLQISWR-HDGRLIDPNVQLAEKYQISGAGSLFVKNVTIPDGGRYECQLKNQFGRAS 637

Human   825 RR--ITVR 830
            ..  :|:|
  Fly   638 ASALVTIR 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ICAM5	NP_003250.3	ICAM_N	31..103	CDD:252248
		Ig2_ICAM-1_like	120..219	CDD:143232
		Ig_2	325..404	CDD:290606	24/99 (24%)
		IG_like	416..487	CDD:214653	14/87 (16%)
		Ig	424..487	CDD:299845	12/79 (15%)
		IG_like	499..569	CDD:214653	21/82 (26%)
		Ig	512..570	CDD:299845	19/70 (27%)
		Ig	594..652	CDD:299845	16/68 (24%)
		Ig	693..742	CDD:299845	17/63 (27%)
		IG_like	<713..740	CDD:214653	9/33 (27%)
		IG_like	759..831	CDD:214653	28/85 (33%)
		IGc2	761..821	CDD:197706	23/69 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..911
Pxn	NP_523891.2	LRR_RI	51..>161	CDD:238064	21/114 (18%)
		leucine-rich repeat	54..77	CDD:275380	3/22 (14%)
		LRR_8	55..112	CDD:290566	10/58 (17%)
		leucine-rich repeat	78..101	CDD:275380	5/24 (21%)
		leucine-rich repeat	102..125	CDD:275380	3/22 (14%)
		LRR_8	124..184	CDD:290566	13/62 (21%)
		leucine-rich repeat	126..149	CDD:275380	8/25 (32%)
		LRR_4	148..185	CDD:289563	6/46 (13%)
		leucine-rich repeat	150..173	CDD:275380	2/22 (9%)
		Ig	240..325	CDD:299845	21/84 (25%)
		IG_like	242..325	CDD:214653	21/82 (26%)
		I-set	366..450	CDD:254352	23/94 (24%)
		Ig	384..451	CDD:143165	21/77 (27%)
		I-set	458..546	CDD:254352	27/90 (30%)
		Ig	472..536	CDD:299845	18/63 (29%)
		I-set	553..644	CDD:254352	29/92 (32%)
		Ig	570..643	CDD:299845	24/74 (32%)
		An_peroxidase	777..1317	CDD:281139
		peroxidasin_like	898..1338	CDD:188658
		VWC	1465..1523	CDD:278520
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910