DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ICAM5 and Icam5

DIOPT Version :9

Sequence 1:	NP_003250.3	Gene:	ICAM5 / 7087	HGNCID:	5348	Length:	924	Species:	Homo sapiens
Sequence 2:	NP_001165550.1	Gene:	Icam5 / 313785	RGDID:	1305039	Length:	917	Species:	Rattus norvegicus

Alignment Length:	924	Identity:	790/924 - (85%)
Similarity:	841/924 - (91%)	Gaps:	7/924 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAFVERGGSLWLNCSTNCPRPERG 65
            ||||||||||.|||||||||||:.|:|||:.||||||||||||.|||||||||||||||||||||
  Rat     1 MPGPSPGLRRTLLGLWAALGLGILGISAVALEPFWADLQPRVALVERGGSLWLNCSTNCPRPERG 65

Human    66 GLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPP 130
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
  Rat    66 GLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELVPLPP 130

Human   131 WQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGAN 195
            ||||||||||||||||||||||||||||||.||||||||.|||||||||:||||||||||||.||
  Rat   131 WQPVGENFTLSCRVPGAGPRASLTLTLLRGGQELIRRSFVGEPPRARGAMLTATVLARREDHRAN 195

Human   196 FSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEA 260
            |||.|||||||||||||.||||||:||||::.|.:|.|.|||.|||||||||:|||||||||.||
  Rat   196 FSCLAELDLRPHGLGLFANSSAPRQLRTFAMPPLSPSLIAPRFLEVGSERPVTCTLDGLFPAPEA 260

Human   261 RVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAP 325
            .|||:||||.|.|:|||:|::.|||||||||.||||.:||:|.||||||:|||:||:|:||||||
  Rat   261 GVYLSLGDQRLHPNVTLDGESLVATATATASEEQEGTKQLMCIVTLGGESRETQENLTVYSFPAP 325

Human   326 LLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVD 390
            |||||||...||:||||:|.|||:|||||||:|||||||||:||||.|:|||:|.|||||.||||
  Rat   326 LLTLSEPEAPEGKMVTVSCWAGARALVTLEGIPAAVPGQPAELQLNVTKNDDKRGFFCDAALDVD 390

Human   391 GETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALG 455
            ||||.||:|:||||||||||||.||||||||||||||||.|||||||||||||||.|||||||||
  Rat   391 GETLRKNQSSELRVLYAPRLDDLDCPRSWTWPEGPEQTLHCEARGNPEPSVHCARPDGGAVLALG 455

Human   456 LLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVP 520
            |||||||||:|||||.|.|.||:||||||||||||||||||||||||||||||||||||||||||
  Rat   456 LLGPVTRALAGTYRCTAINGQGQAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVP 520

Human   521 PPDVICVRSGELGAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWT 585
            ||.|.|||||: ..|:||.|||||||||||||||.|.||||||||||||||||.|||..||||||
  Rat   521 PPSVSCVRSGK-EEVMEGPLRVAREHAGTYRCEAINARGSAAKNVAVTVEYGPSFEELGCPSNWT 584

Human   586 WVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNR 650
            ||||||:||||||||||:|.|:||||.||:|||:|||...:...|....|..|:||||:||||||
  Rat   585 WVEGSGKLFSCEVDGKPEPRVECVGSEGASEGVVLPLVSSNSGSRNSMTPGNLSPGIYLCNATNR 649

Human   651 HGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRV 715
            |||..|||||||||||:||||:|||||||||||||:||||:|||||||.|||||||....|:.:|
  Rat   650 HGSTVKTVVVSAESPPQMDESSCPSHQTWLEGAEATALACSARGRPSPRVRCSREGAARLERLQV 714

Human   716 SREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQIS 780
            ||||||||.|||||||||||||||||||||||||||||||| .||||||||||||||||||||||
  Rat   715 SREDAGTYLCVATNAHGTDSRTVTVGVEYRPVVAELAASPP-SVRPGGNFTLTCRAEAWPPAQIS 778

Human   781 WRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAG 845
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   779 WRAPPGALNLGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAG 843

Human   846 GAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGGAGGAAGAEGGPEAAGGAAES 910
            ||||||||||||||||||||||||||||||||||||||||    ||||..|||||.|.. |.|||
  Rat   844 GAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLN----GAGGTPGAEGGAETP-GTAES 903

Human   911 PAEGEVFAIQLTSA 924
            ||:||||||||||:
  Rat   904 PADGEVFAIQLTSS 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ICAM5	NP_003250.3	ICAM_N	31..103	CDD:252248	69/71 (97%)
		Ig2_ICAM-1_like	120..219	CDD:143232	91/98 (93%)
		Ig_2	325..404	CDD:290606	61/78 (78%)
		IG_like	416..487	CDD:214653	63/70 (90%)
		Ig	424..487	CDD:299845	55/62 (89%)
		IG_like	499..569	CDD:214653	59/69 (86%)
		Ig	512..570	CDD:299845	47/57 (82%)
		Ig	594..652	CDD:299845	36/57 (63%)
		Ig	693..742	CDD:299845	39/48 (81%)
		IG_like	<713..740	CDD:214653	23/26 (88%)
		IG_like	759..831	CDD:214653	70/71 (99%)
		IGc2	761..821	CDD:197706	58/59 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..911		12/19 (63%)
Icam5	NP_001165550.1	ICAM_N	32..103	CDD:252248	69/70 (99%)
		Ig2_ICAM-1_like	120..219	CDD:143232	91/98 (93%)
		Ig	323..399	CDD:299845	60/75 (80%)
		IG_like	416..487	CDD:214653	63/70 (90%)
		Ig	424..487	CDD:299845	55/62 (89%)
		IG_like	499..568	CDD:214653	59/69 (86%)
		Ig	512..569	CDD:299845	47/57 (82%)
		I-set	572..659	CDD:254352	59/86 (69%)
		Ig	588..659	CDD:299845	46/70 (66%)
		IG_like	673..739	CDD:214653	54/65 (83%)
		Ig	687..738	CDD:143165	40/50 (80%)
		IG_like	756..829	CDD:214653	70/72 (97%)
		IGc2	759..819	CDD:197706	58/59 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83678084
Domainoid	1	1.000	951	1.000	Domainoid score	I1774
eggNOG	1	0.900	-	-		E1_2AT49
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2447
Inparanoid	1	1.050	1602	1.000	Inparanoid score	I2397
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG35736
OrthoDB	1	1.010	-	-		D118151at9347
OrthoFinder	1	1.000	-	-		FOG0006676
OrthoInspector	1	1.000	-	-		oto129500
orthoMCL	1	0.900	-	-		OOG6_123705
Panther	1	1.100	-	-	LDO	PTHR13771
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11524
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.270