Protein Alignment TKT and CG5103

DIOPT Version :10

• Sequence 1: NP_001244957.1
• Gene: TKT / 7086
• HGNCID: 11834
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_649036.1
• Gene: CG5103 / 40012
• FlyBaseID: FBgn0036784
• Length: 623
• Species: Drosophila melanogaster
• Alignment Length: 632
• Identity: 341/632 - (53%)
• Similarity: 443/632 - (70%)
• Gaps: 20/632 - (3%)

Human     6 KPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKSQDPRNPHNDR 70
            |.|.:.:|.|||.|.:|||.||.:|.||.|||||||.|.||||.||||..||...:.||:|.:||
  Fly     5 KLDSKVVQNLKDVAQKLRIHSITSTQAAKSGHPTSCASLAEIMTVLFFQQMRLNLKHPRDPSSDR 69

Human    71 FVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGM 135
            .|||||||||||||||||||.....||.||||:.|||:|||.|:.:|.||:|||||||:..|.||
  Fly    70 LVLSKGHAAPILYAVWAEAGLFPVEELRNLRKVDSDLEGHPTPRLSFVDVSTGSLGQGISVAAGM 134

Human   136 AYTGKYFDKASLPSSWDYSYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDP 200
            ||.||:.|||        .||.|.::||||.:||:|||::.||..|.||||..|.|:|::..||
  Fly   135 AYVGKHLDKA--------DYRTYVIVGDGEATEGAVWESLHFAGHYCLDNLCVIFDMNKIFCSD- 190

Human   201 APLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAF---GQAKHQPTAIIAKTFKGRGITGVEDK 262
              :..:|::|::|.:|||::|::::||.::||.|||   ...|.:|||::|:|.||:...|:|..
  Fly   191 --IGTEMEVYRERLDAFGFNALVLNGHDIDELAKAFINAASTKGKPTALLARTTKGKDFLGIEGI 253

Human   263 ESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQ----EDAPSVDIANIRMPSLPSYKVGDKI 323
            |..|.:||.|. ||..|:.:..:| :...:..||.:    ..||.|.|.||.:.|.|:|::||.:
  Fly   254 EEMHAQPLGKR-AESAIKHLQMKI-ANPNVRLTPKKVGKCGHAPEVHINNIMLCSPPNYRLGDSV 316

Human   324 ATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRN 388
            |.|.|||.||||:...:.|:|||||||||||:::..:...|:|||||:.|:||:|.:|||...|.
  Fly   317 APRLAYGTALAKIAADNPRVIALDGDTKNSTYADKMRNAFPERFIECFTAQQNLVGVAVGATCRR 381

Human   389 RTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTV 453
            |||.|.||:|.|||||||||||.|||.:|:|..|||||.||||||||||.|||:|||||:|.|||
  Fly   382 RTVAFVSTYATFFTRAFDQIRMGAISHTNVNFAGSHCGCSIGEDGPSQMGLEDMAMFRSIPGSTV 446

Human   454 FYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLKSKDDQVTVIGAGV 518
            |||:|.|:||:||||||||||:|:|||:.|...:||||:|.|.||..|||.:...|:|.:|||||
  Fly   447 FYPTDAVSTERAVELAANTKGVCYIRTTYPSTTVIYNNDEVFAVGLGKVVRQKPSDEVLLIGAGV 511

Human   519 TLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSA 583
            ||:|.|||||.|:::.|..||:||||:||||..||:...:..:|||:.|||||.:||:||||.||
  Fly   512 TLYECLAAAERLEEDCITARVIDPFTVKPLDVGLIVKHGKLCRGRIVVVEDHYQQGGLGEAVLSA 576

Human   584 VVGEPGITVTHLAVNRVPRSGKPAELLKMFGIDRDAIAQAVRGLITK 630
            :.......|.||.:..|||||.||.||.|||:....|.:|...::.|
  Fly   577 LADYRNFVVKHLYITTVPRSGPPAVLLDMFGVSSRNIYKASLAIMKK 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TKT	NP_001244957.1	PRK05899	8..628	CDD:235639	339/626 (54%)
CG5103	NP_649036.1	PRK05899	12..621	CDD:235639	338/621 (54%)