DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a16 and CG33233

DIOPT Version :9

Sequence 1:	NP_081848.1	Gene:	Slc22a16 / 70840	MGIID:	1918090	Length:	649	Species:	Mus musculus
Sequence 2:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster

Alignment Length:	406	Identity:	82/406 - (20%)
Similarity:	145/406 - (35%)	Gaps:	129/406 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse   161 IIFGVMLGSITFSYLSDRFGRRMALWCTSIGVFFFGIASLFIFDYLSFMITRFFLVMASSGYFV- 224
            ::.|::...:...:|:||:||:..:....:|...|.:.|..:.|..|..:.|..:     |.|:
  Fly    65 LLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIV-----GTFLS 124

Mouse   225 VVFVYVMEIIGK-KARTWASIHL------NTFFAIGAMLVALA------------SYLLKTW--- 267
            .|....:..:|: .|..|..|.:      .....|...|||:|            ||.|:.|
  Fly   125 AVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPNNFNVDLSSSYNLRVWRFL 189

Mouse   268 --------WLYQIILCIVTTPFILCCWMLPETPFWLLSEGRYKEAQGTVDTMAVWNKSSSCDLVE 324
                    ||..:.:|:|           ||||.:|:|..|..:|...:..:...|:....|
  Fly   190 MMFFMIPGWLALVGICLV-----------PETPHFLMSVNRPDKALLALKWICRMNRKKWED--- 240

Mouse   325 LLSLDVTRSHNKSPHSIR---------KHRLADLFHNLDVAKMTLIVWL---DWFTA-NLGYYMF 376
               :|:|.|..||..:.:         :::|  ||....|.|..:.::|   .:||: .||.:.
  Fly   241 ---VDITLSEEKSSTNDQEGFWKTVWYEYKL--LFSKPHVFKFFICLFLIFGIFFTSIGLGIWF- 299

Mouse   377 GKEVIRRKEN------------------------------------------EPLYLLLVGAMEI 399
              .|||..:|                                          :|:|   .|...|
  Fly   300 --PVIRNMDNSGSNRLCDLVNNNPTFINHEADDTNGTDSESPKCNDEMTNLIDPVY---YGFTYI 359

Mouse   400 PAYICLCIWLKRVGRRKTMLLFLLVSSLTCMLHVVMPSDYKTAKRMVALLVKSVISSVF--AFIY 462
            ..:|...:.:..:.|:..:.|.:|:|       :::.......|:...:|:..|:..|.  ..|.
  Fly   360 GCFILASVLVHWMTRKYVIALHILIS-------MILGISLNIMKQPTVVLIFFVLMMVLPGVLIP 417

Mouse   463 LYTAELYPTTVRCLAV 478
            |.|:.|    |.||.|
  Fly   418 LATSVL----VDCLPV 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a16	NP_081848.1	2A0119	14..535	CDD:273328	82/406 (20%)
		MFS	163..525	CDD:119392	82/404 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..560
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..649
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	82/406 (20%)
		MFS	23..>208	CDD:119392	32/158 (20%)
		MFS	354..>482	CDD:304372	19/87 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843398
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930