DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TK2 and Tk2

DIOPT Version :9

Sequence 1:	NP_004605.4	Gene:	TK2 / 7084	HGNCID:	11831	Length:	265	Species:	Homo sapiens
Sequence 2:	NP_001099636.1	Gene:	Tk2 / 291824	RGDID:	1309279	Length:	270	Species:	Rattus norvegicus

Alignment Length:	270	Identity:	216/270 - (80%)
Similarity:	236/270 - (87%)	Gaps:	5/270 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLLWPLRGWAARALRCFGPGSRGSPA---SGPGPRRVQRRAWPPDK--EQEKEKKSVICVEGNIA 60
            |||..||.||||:||..||||.|||.   ||.||....|||.||||  |::||||:|:|:|||||
  Rat     1 MLLRSLRSWAARSLRSMGPGSSGSPGSLDSGAGPLWAPRRACPPDKDREKDKEKKAVVCIEGNIA 65

Human    61 SGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQ 125
            ||||||||||||.||||||.|||.|||||.|||||.||||:||||||||||||||||||:|||||
  Rat    66 SGKTTCLEFFSNTTDVEVLMEPVLKWRNVHGHNPLSLMYHNASRWGLTLQTYVQLTMLDQHTRPQ 130

Human   126 VSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCY 190
            :|.||||||||:|||||||||||||||||||||.:||||||||::|:||||||||||||.||.||
  Rat   131 MSPVRLMERSIYSARYIFVENLYRSGKMPEVDYAILSEWFDWIIKNIDVSVDLIVYLRTTPEICY 195

Human   191 QRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRI 255
            ||||.||||||||||:|||.|||||:||||:.|||||.|||||||||||::|:|||||||||.||
  Rat   196 QRLKMRCREEEKVIPVEYLSAIHHLYEEWLVTGSLFPAAAPVLVIEADHNLEKMLELFEQNRARI 260

Human   256 LTPENRKHCP 265
            |||||.||.|
  Rat   261 LTPENWKHGP 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TK2	NP_004605.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..47		17/31 (55%)
		dNK	53..265	CDD:279974	180/211 (85%)
		DTMP_kinase	53..238	CDD:161676	158/184 (86%)
Tk2	NP_001099636.1	dNK	58..265	CDD:279974	176/206 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83680091
Domainoid	1	1.000	375	1.000	Domainoid score	I11731
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3392
Inparanoid	1	1.050	442	1.000	Inparanoid score	I12623
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54257
OrthoDB	1	1.010	-	-		D1505356at2759
OrthoFinder	1	1.000	-	-		FOG0001503
OrthoInspector	1	1.000	-	-		oto141024
orthoMCL	1	0.900	-	-		OOG6_102194
Panther	1	1.100	-	-	LDO	PTHR10513
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6020
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.370