DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TJP1 and Patj

DIOPT Version :9

Sequence 1:	XP_016878010.1	Gene:	TJP1 / 7082	HGNCID:	11827	Length:	1878	Species:	Homo sapiens
Sequence 2:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster

Alignment Length:	1008	Identity:	196/1008 - (19%)
Similarity:	326/1008 - (32%)	Gaps:	326/1008 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    61 PSSENPNGATSSVSQGKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGF 125
            |.|.:.:|...  .:.:|..:..||.  ....|.:.|:.::.:..:            ::...|.
  Fly   111 PGSPDKSGGVG--EEPRPQSQNSKGA--GVADLYATDYAQIQAIEL------------VNDGTGL 159

Human   126 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAFAVQQL 188
            ||||.  |.|:        :.:::..:|.||.|  :|:|:..|.:..:..|::..:........|
  Fly   160 GFGII--GARN--------SGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVL 214

Human   189 RKSGKNAKITIRRKKKVQIPVSRPDPEP----------VSDNEEDSYDEEIHDPRSGRSGVVNRR 243
            |:||.:.::.:.|..:..:|..:...||          |...|.:.|...     :|...:....
  Fly   215 RQSGTHVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLIS-----TGYPEIFGES 274

Human   244 SEKIWPR-----DRSASRERS---LSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLA---- 296
            |....|:     ||...|..:   :.|..|...:.:....:..:|.|.|....  .|:.:|
  Fly   275 STASTPQTTTEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANG--LGITIAGYVC 337

Human   297 -----SHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRD 356
                 |.||||.:|..|.|...|.|:..|.:::::|...:..|...|..|:::|...:.:.::|
  Fly   338 EKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLER- 401

Human   357 ERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRH 421
                .|..|.......:..|:::        |.|...|         :.||:|  ...|...:..
  Fly   402 ----YLRGPKFEQLQQAIAANDK--------LPSSAPG---------TPSRAP--MPTPVATTSS 443

Human   422 SPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNE-----KQTPSLPE---- 477
            :...||....|..:||.:..|.|..|        ||.:|..:|.....     ||..::.:
  Fly   444 ATTTPSRSITRELEEEALPAPEAFMT--------TPPSVTTMTTTTLSSFGAGKQLVAVRDSLDG 500

Human   478 -PKPVYAQVGQPDVDLPVSPSDGVLPNSTH----------EDGILRPSMKLV------------K 519
             .|.:..:| .|..|...:.:.||:....:          |..|:|...|:|            |
  Fly   501 STKIIPTEV-VPLADKTEAKNSGVITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVIVAQIKK 564

Human   520 FRKGDSVGLRLAGGNDV--------GIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREE 575
            |..| .:|:.|.|..||        ..::..:|.|.|....| |..||::|.||......:...|
  Fly   565 FAVG-GLGISLEGTVDVEGGREVRPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLE 628

Human   576 AVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVD 640
            .|..|.:||.  :|.::..:.::                .:...:..::...||.|...:....|
  Fly   629 VVAILKELPL--DVRMVCGRNRN----------------SSLLPFSDDTLKKLSNNFENLLPATD 675

Human   641 TLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGD-----RADFWRFRGL 700
            .|...|....||                             |....|.||     .|.|.:.
  Fly   676 RLVKAKSDGSLA-----------------------------TAGSVADGDSVAAAAASFSKL--- 708

Human   701 RSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIA 765
                    |||.                        |.|:|...         :...:|.|.::.
  Fly   709 --------KSRS------------------------LEPLTGLA---------MWSSQPQIIELV 732

Human   766 KSEPRDAGTDQRSSGIIRLHTIKQIID-QDKHALLDVTPNAVDRLNYAQWYPIVV-FLNPDSKQG 828
            |.:        |..|.       .|:| ||.   ||  ||  |.|       ||: .|.|.   |
  Fly   733 KGD--------RGLGF-------SILDYQDP---LD--PN--DTL-------IVIRSLVPG---G 765

Human   829 VKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 893
            |..:..||.|..|.                  ||..:|||.:      .:|.:|:|    .|...
  Fly   766 VAQLDGRLIPGDRL------------------LFVNSINLEN------ASLDQAVQ----ALKGA 802

Human   894 SEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDE 958
            |:|......:..|.:.|:.|...|..       ||.|..|.|.:.
  Fly   803 SKGVVRIGVAKPLPMTDNSLKACSNA-------STTSEETLDAQP-------------------- 840

Human   959 VGTPPESAITRSSEPVREDSSGMHHENQTYPPY 991
              :||  |:...:.|....|:.|..|....|.:
  Fly   841 --SPP--ALPTVAPPAMPPSASMGAEPDLIPDW 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TJP1	XP_016878010.1	None
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492	19/81 (23%)
		PDZ_signaling	318..400	CDD:238492	21/83 (25%)
		PDZ_signaling	557..643	CDD:238492	24/88 (27%)
		PDZ_signaling	726..807	CDD:238492	36/140 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4314
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860