DRSC/TRiP Functional Genomics Resources

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Protein Alignment TIMP4 and Timp

DIOPT Version :10

Sequence 1:NP_003247.1 Gene:TIMP4 / 7079 HGNCID:11823 Length:224 Species:Homo sapiens
Sequence 2:NP_731461.1 Gene:Timp / 41248 FlyBaseID:FBgn0025879 Length:210 Species:Drosophila melanogaster


Alignment Length:216 Identity:48/216 - (22%)
Similarity:96/216 - (44%) Gaps:40/216 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    12 VLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKI--SSEKVVPASADPADTEKMLRYE 74
            :||:.:.|....|  .:||||.|:|||.|...:..|::.::  .|:.:.|...         .|:
  Fly    12 LLLVAVFAFYGRP--ADACSCMPSHPQTHFAQADYVVQLRVLRKSDTIEPGRT---------TYK 65

Human    75 IKQIKMFKGFEKVKDV---QYIYTPFDSSLCGVKLEANSQKQYLLTGQVLSDGKVFIHLCNYIEP 136
            :...:.:|...:.:.:   ..:.||.|.::||:.|:..  |.|::.|::.:     :::|:|.:.
  Fly    66 VHIKRTYKATSEARRMLRDGRLSTPQDDAMCGINLDLG--KVYIVAGRMPT-----LNICSYYKE 123

Human   137 WEDLSLVQRESLNHHYHLNCGCQITTCYTVPC--TISAPNECLWTDWLLERKLYGYQAQHY-VCM 198
            :..:::.:|...:..|.....|.:|.|:...|  ..:..:.|.|:.       :|....:| .||
  Fly   124 YTRMTITERHGFSGGYAKATNCTVTPCFGERCFKGRNYADTCKWSP-------FGKCETNYSACM 181

Human   199 KH----VDGT---CSWYRGHL 212
            .|    |:|.   |.|.|..|
  Fly   182 PHKVQTVNGVISRCRWRRTQL 202

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
TIMP4NP_003247.1 NTR_TIMP 30..213 CDD:239640 43/198 (22%)
Involved in metalloproteinase-binding. /evidence=ECO:0000250|UniProtKB:P16035 30..33 2/2 (100%)