Protein Alignment TIE1 and KIN1

DIOPT Version :9

• Sequence 1: NP_005415.1
• Gene: TIE1 / 7075
• HGNCID: 11809
• Length: 1138
• Species: Homo sapiens
• Sequence 2: NP_010407.1
• Gene: KIN1 / 851700
• SGDID: S000002529
• Length: 1064
• Species: Saccharomyces cerevisiae
• Alignment Length: 539
• Identity: 114/539 - (21%)
• Similarity: 185/539 - (34%)
• Gaps: 177/539 - (32%)

Human   586 DGTRGQERRENVSSPQARTAL-LTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRH 649
            ||...........|..|...| :.|.:|....|.:.         |..|||.:....:|     :
Yeast    20 DGNSESNSMHTQPSTMAPATLRMMGKSPQQQQQQNT---------PLMPPADIKYANNG-----N 70

Human   650 LHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRY 714
            .|.....:.:::|..|..|..|.|  ....:.:|:...|.|                      :.
Yeast    71 SHQAEQKERQVELEGKSRENAPKP--NTTSQSRVSSSQGMP----------------------KQ 111

Human   715 LFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAA 779
            ..|     :.|||| ..||  |:|.|...:..:.:.|...|                .|...:..
Yeast   112 FHR-----KSLGDW-EFVE--TVGAGSMGKVKLAKHRYTNE----------------VCAVKIVN 152

Human   780 LLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDL 844
            ..|     ::.||:.:..  .....|:.:|:         |:.||:.|      :..:..|
Yeast   153 RAT-----KAFLHKEQML--PPPKNEQDVLE---------RQKKLEKE------ISRDKRT---- 191

Human   845 IGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKN 909
            |.|.:.||::                                         :||:|..|...|..
Yeast   192 IREASLGQIL-----------------------------------------YHPHICRLFEMCTL 215

Human   910 RGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQ 974
            ..:.|:..||...|.|||::             .:||   ::...|..:||...|:.:.||....
Yeast   216 SNHFYMLFEYVSGGQLLDYI-------------IQHG---SIREHQARKFARGIASALIYLHANN 264

Human   975 FIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTM-----GRLPVRWMAIESLNYSVYT-TK 1033
            .:||||...|:::.::...||.|||||   .:|..:..     |.|  .:.|.|.|..:.|| .:
Yeast   265 IVHRDLKIENIMISDSSEIKIIDFGLS---NIYDSRKQLHTFCGSL--YFAAPELLKANPYTGPE 324

Human  1034 SDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQC--------- 1089
            .|||||||:|:.:| .|..|:.....:.|:||:.|| ::|.|::...||..|:.:.
Yeast   325 VDVWSFGVVLFVLV-CGKVPFDDENSSVLHEKIKQG-KVEYPQHLSIEVISLLSKMLVVDPKRRA 387

Human  1090 ---------WRDRPYERPP 1099
                     |..|.:..||
Yeast   388 TLKQVVEHHWMVRGFNGPP 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TIE1	NP_005415.1	ig	129..210	CDD:278476
		EGF_CA	227..256	CDD:238011
		EGF_2	315..344	CDD:285248
		ig	356..441	CDD:278476
		fn3	452..536	CDD:278470
		fn3	548..632	CDD:278470	9/46 (20%)
		FN3	644..736	CDD:238020	16/91 (18%)
		PTKc_Tie1	836..1132	CDD:270671	70/288 (24%)
		TyrKc	839..1107	CDD:197581	70/285 (25%)
KIN1	NP_010407.1	STKc_Kin1_2	118..398	CDD:270979	86/388 (22%)
		MARK_C_like	890..1062	CDD:213377

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4853
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950