DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TIE1 and Cad96Ca

DIOPT Version :9

Sequence 1:	NP_005415.1	Gene:	TIE1 / 7075	HGNCID:	11809	Length:	1138	Species:	Homo sapiens
Sequence 2:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster

Alignment Length:	741	Identity:	202/741 - (27%)
Similarity:	308/741 - (41%)	Gaps:	224/741 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   484 YRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQL--SRPGEGGEGAW----------GPPT 536
            ||||.|.   |.:|.:.|:.:...:..|.. .|:|..|  |||     |.|          |||.
  Fly   168 YRPQTSI---SNVVHNISQFLPRFDQLPGV-QSIRNGLPNSRP-----GGWYPPVPQNNIFGPPP 223

Human   537 LMTTDCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRE------ 595
            ......|.|                       |.:|              |.||::..|
  Fly   224 FGNNYPPPP-----------------------PNIP--------------GVRGEQSGEEEQPDE 251

Human   596 --------NVSS--PQARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHL 650
                    .:||  |::||. ||.:|.....:::           ::.||....|..|
  Fly   252 EVTPTTPVRISSTTPKSRTK-LTPITANNSTRVE-----------SAIPAETTTPSGG------- 297

Human   651 HAQALSDSEIQLTWKHPEALPGPISKYVVE------VQVAGGAGDPLWIDVDRPEETSTII---- 705
                           |......||:.:.::      |...||    .::.:      :.::
  Fly   298 ---------------HHNNSSSPITIFSLKSGTIPIVVTVGG----FFVAI------AVLLAYLC 337

Human   706 -RGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGL-----------QAEGPVQ-ESRAAEEGL 757
             |.|.|.:|.|.:.:.. :.|...||   :|.|.:.|           |.:|||. .:|......
  Fly   338 RRRLCAISRTLKKTKEK-EELAKKSN---QSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWER 398

Human   758 DQQLILAVV--------GSVSAT-----------------CLTILAALLTLVCIRRSCLHRRRTF 797
            |||:.:|..        |.||:.                 |||..|.
  Fly   399 DQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAG------------------ 445

Human   798 TYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWE----DITFEDLIGEGNFGQVIRA-- 856
              .||:.|...    :|.....|               ||    .:.|.:::|||.||||.|.
  Fly   446 --SSGAPENAF----AGEANCDR---------------WEFPRYRLKFFNILGEGAFGQVWRCEA 489

Human   857 --MIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEY 919
              :...:|: ...|:|.|||.|:|.|.:|...||||:..|..|.|:::|||.|.::...::.:||
  Fly   490 TNINGNEGI-TTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEY 553

Human   920 APYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARN 984
            ...|.|..:||.||   .:..:...||.::.|:|..|..|....|.||.||:.:..|||||||||
  Fly   554 VNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARN 615

Human   985 VLVGENLASKIADFGLSRG---EEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEI 1046
            :|:.::...|:||||.:|.   .::|.:|:.|:||:||||.|||..::::.|||:||||:|:|||
  Fly   616 ILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEI 680

Human  1047 VSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRML 1111
            |:||.|||.|::.|::..|:..|||:|:|.:|..|:|.:|..||...|.|||.||:|...|.::|
  Fly   681 VTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLL 745

Human  1112 EARKAYVNMSLFENFTYAGIDATAEE 1137
            .....|:.:..|.:..|..|.:.:.|
  Fly   746 HTEMDYIELERFPDHNYYNIVSLSGE 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TIE1	NP_005415.1	ig	129..210	CDD:278476
		EGF_CA	227..256	CDD:238011
		EGF_2	315..344	CDD:285248
		ig	356..441	CDD:278476
		fn3	452..536	CDD:278470	19/63 (30%)
		fn3	548..632	CDD:278470	14/99 (14%)
		FN3	644..736	CDD:238020	14/102 (14%)
		PTKc_Tie1	836..1132	CDD:270671	122/306 (40%)
		TyrKc	839..1107	CDD:197581	115/274 (42%)
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	115/274 (42%)
		PTKc	474..742	CDD:270623	114/271 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006344
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910