DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TIE1 and htl

DIOPT Version :9

Sequence 1:NP_005415.1 Gene:TIE1 / 7075 HGNCID:11809 Length:1138 Species:Homo sapiens
Sequence 2:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster


Alignment Length:825 Identity:227/825 - (27%)
Similarity:340/825 - (41%) Gaps:225/825 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   424 WECRVS------TSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRL 482
            |..|.|      |||........:::..|.|.:...|.:. .|::::...|.:.|.:...:....
  Fly     5 WSWRASHSTITMTSGSLVVLFLLLSIWQPAVQVEGRRQMA-NSQEMIKDHLGARSQNKTPAITNN 68

Human   483 HYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPP------------ 535
            ..:...|:.|......|..:|        |....|.|. |:|      .|..|            
  Fly    69 ANQSSTSSADLDDGAADDDDN--------KADLPVNVS-SKP------YWRNPKKMSFLQTRPSG 118

Human   536 TLMTTDC-----PEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLR-LWDGTRGQERR 594
            :|:|.:|     |||.:.     |:..||    |.|:.        |.|.|.| .|         
  Fly   119 SLLTLNCHALGNPEPNIT-----WYRNGT----VDWTR--------GYGSLKRNRW--------- 157

Human   595 ENVSSPQARTALLTGLTPGT--HYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSD 657
                     |..:..|.||.  :|...|    |..||                ..||.....:||
  Fly   158 ---------TLTMEDLVPGDCGNYTCKV----CNSLG----------------CIRHDTQVIVSD 193

Human   658 SEIQLTWKHPEALPGPIS-------------KYVVEVQVAGGAGDPLWIDVDRPEETS-TIIRGL 708
               ::..| |..:.||::             ||:.::     .....||.|.....|: :..|.:
  Fly   194 ---RVNHK-PILMTGPLNLTLVVNSTGSMHCKYLSDL-----TSKKAWIFVPCHGMTNCSNNRSI 249

Human   709 NASTR---YLFRMRASIQGLGDWSNTVEESTLG--NGLQAEGPVQESRAAEEGLDQQLILAVVGS 768
            .|..:   ....:|...:|   |...||.::||  |.......|:.....|.|:       ..||
  Fly   250 IAEDKDQLDFVNVRMEQEG---WYTCVESNSLGQSNSTAYLRVVRSLHVLEAGV-------ASGS 304

Human   769 VSATCLT-----------ILAALLTLVCIRR----SCLHRRRTFTYQ----------SGSGEETI 808
            :.:|...           .:..|.....||:    ..|.:|....:|          .|.|:   
  Fly   305 LHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGD--- 366

Human   809 LQFSSGTLTLTRRPKL--------------QPEPLS---YPV-LEWE----DITFEDLIGEGNFG 851
               |||::.....|.:              :|.|.:   :|: ..||    .:.....:|||.||
  Fly   367 ---SSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFG 428

Human   852 QVIRAMIKKDGLKMNA--AIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLY 914
            :|:.|.:.      ||  |:||:||..:::|......|:||:..:|.|.|||||||.|...|.||
  Fly   429 RVVMAEVN------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLY 487

Human   915 IAIEYAPYGNLLDFLRKSRVLETDPAFAREHG----------TASTLSSRQLLRFASDAANGMQY 969
            :.:||||:|||.|||.|:|      .|.|:..          .|..::.:.|::||...|.||.|
  Fly   488 VIVEYAPHGNLKDFLYKNR------PFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDY 546

Human   970 LSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKKTMGRLPVRWMAIESLNYSVYT 1031
            |:.::.||||||||||||.::...|||||||:|   ..:.|.|.|.||||::|||.|||....|.
  Fly   547 LASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYD 611

Human  1032 TKSDVWSFGVLLWEIVSLGGTPY-CGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPY 1095
            :||||||:|:|||||::.|..|| ..|:..|||..|..|.|||:|..|...:|.||||||.....
  Fly   612 SKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNAD 676

Human  1096 ERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGID---ATAEE 1137
            :||||.:|...:.::|:.::.|:::.:      |.:|   :|::|
  Fly   677 DRPPFTEIVEYMDKLLQTKEDYLDVDI------ANLDTPPSTSDE 715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TIE1NP_005415.1 ig 129..210 CDD:278476
EGF_CA 227..256 CDD:238011
EGF_2 315..344 CDD:285248
ig 356..441 CDD:278476 6/22 (27%)
fn3 452..536 CDD:278470 15/95 (16%)
fn3 548..632 CDD:278470 19/86 (22%)
FN3 644..736 CDD:238020 21/108 (19%)
PTKc_Tie1 836..1132 CDD:270671 131/315 (42%)
TyrKc 839..1107 CDD:197581 126/283 (45%)
htlNP_524394.2 Ig 112..191 CDD:299845 27/133 (20%)
IG_like 113..191 CDD:214653 27/132 (20%)
IG_like 205..289 CDD:214653 17/91 (19%)
PKc_like 404..692 CDD:304357 129/299 (43%)
STYKc 416..688 CDD:214568 126/283 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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