DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TIE1 and tor

DIOPT Version :9

Sequence 1:	NP_005415.1	Gene:	TIE1 / 7075	HGNCID:	11809	Length:	1138	Species:	Homo sapiens
Sequence 2:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster

Alignment Length:	970	Identity:	216/970 - (22%)
Similarity:	355/970 - (36%)	Gaps:	319/970 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   314 DCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNP 378
            |||:     ||    .|.|.:       ...:::.::..|....||:.|.::.:..
  Fly    59 DCRI-----NG----TFPGAL-------RKVQENYQMNMICRTESEIVFQIDWVQH--------- 98

Human   379 FPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNV 443
              .||:..  .|:.|.::...|:.:..|.||      |.|:|..|
  Fly    99 --SRGTEP--APNATYIIRVDAVKDDNKETA------LYLSDDNF-------------------- 133

Human   444 KVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIV--VDPSE--NV 504
                  |..|.|.:..:..:..   ::..|||..|.:     .:|.|  ::|::  ..||:  .|
  Fly   134 ------LILPGLESNSTHNITA---LAMHGDGSYSLI-----AKDQT--FATLIRGYQPSKMGAV 182

Human   505 TLMNLRPKTGYSVRVQLSRPGE----GGEGAWGPP------------TLMTTDCPEPLLQPWLEG 553
            .|:...|           :|.:    ..|..|.|.            :..:.:..|||
  Fly   183 NLLRFVP-----------QPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPL------- 229

Human   554 WHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGL-TPGTHYQ 617
             .|:..||.::                            .|..|.:.:.......|: |.....:
  Fly   230 -EVQFRDRKKL----------------------------YRHTVDNLEFDKQYHVGVRTVNIMNR 265

Human   618 LDVQLYHCTLLGPAS----PPAHVLLPPSGPPAPRHLHAQALSD-SEIQLTWKHPEALPGPISKY 677
            |:..|....:..|:.    |..:.|.||..|........|.|.: ..:.:||..|..||...:.:
  Fly   266 LESDLQWLPIAVPSCLDWYPYNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDNYTLH 330

Human   678 VVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLG---N 739
            :.:: ..||......:|.:|               .:.:..:.::.|.....:.|.:|..|   :
  Fly   331 IFDL-FKGGTELNYTLDQNR---------------SHFYVPKITVLGSHFEVHLVAQSAGGKNVS 379

Human   740 GLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSG 804
            ||..: .|.......||...:|:|.::  |...|:.:|.:|  ..|.|    :|......|..:.
  Fly   380 GLTLD-KVHRGVLLSEGNMVKLVLFII--VPICCILMLCSL--TFCRR----NRSEVQALQMDAK 435

Human   805 EETILQF------SSGTL-TLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDG 862
            :....:|      |||.| ||:....|  |.:....:|...:..:|::|||.||.|.|.:.|
  Fly   436 DAKASEFHLSLMDSSGLLVTLSANESL--EVMDELEVEPHSVLLQDVLGEGAFGLVRRGVYK--- 495

Human   863 LKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLG-ACKNRGYLYIAIEYAPYGNLL 926
             |...|:|:||:..::.|...|..|:::|..:|.||||:.::| :.:....:.:.|||...|:|.
  Fly   496 -KRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQ 559

Human   927 DFLR------------------------------------------------------------- 930
            :|||
  Fly   560 NFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHS 624

Human   931 ----------------------------------------------------------------K 931
                                                                            |
  Fly   625 SRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNK 689

Human   932 SRVLETDPAF----AREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLA 992
            .|:.|....|    :.:......|....||..|...|.||::|::.:.:||||||||||:..:.:
  Fly   690 KRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRS 754

Human   993 SKIADFGLSRG---EEVYVKK-TMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTP 1053
            .|||||||||.   |.||.|. ..|:||::|:|:|||.:.|||::||||||||||:||.:|||.|
  Fly   755 IKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMP 819

Human  1054 YCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEA 1113
            |..::.::|.:.|.||:||::|..|..|::.||..||...|..||.|:.:..:||.|:.|
  Fly   820 YPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILA 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TIE1	NP_005415.1	ig	129..210	CDD:278476
		EGF_CA	227..256	CDD:238011
		EGF_2	315..344	CDD:285248	6/28 (21%)
		ig	356..441	CDD:278476	15/84 (18%)
		fn3	452..536	CDD:278470	18/103 (17%)
		fn3	548..632	CDD:278470	10/84 (12%)
		FN3	644..736	CDD:238020	14/92 (15%)
		PTKc_Tie1	836..1132	CDD:270671	116/412 (28%)
		TyrKc	839..1107	CDD:197581	112/401 (28%)
tor	NP_476762.1	FN3	199..261	CDD:214495	13/97 (13%)
		STYKc	475..873	CDD:214568	112/401 (28%)
		PTKc	479..873	CDD:270623	112/397 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100