Protein Alignment TIE1 and NimA

DIOPT Version :9

• Sequence 1: NP_005415.1
• Gene: TIE1 / 7075
• HGNCID: 11809
• Length: 1138
• Species: Homo sapiens
• Sequence 2: NP_001285918.1
• Gene: NimA / 318930
• FlyBaseID: FBgn0261514
• Length: 565
• Species: Drosophila melanogaster
• Alignment Length: 549
• Identity: 123/549 - (22%)
• Similarity: 173/549 - (31%)
• Gaps: 170/549 - (30%)

Human   176 GRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAG------RWGPG--CTKECPGCL 232
            |:.||.|..|.|..||..|...:..:          |:...||      ..|||  |.:|.|...
  Fly     8 GKLLLLLAMVLPLGSGQNSTLKINTN----------VKDIEAGVVALPSIQGPGNICIREEPYVE 62

Human   233 HGGV-------------CHDHDGECVC----------PPGFTGTRCEQACREGRFGQ------SC 268
            |..|             |.:....|..          ......||..:.|.:|..|.      :|
  Fly    63 HVQVPEMQPVRVRTSSWCMEIPPRCATFKTEMREVMRVQKLNKTRTVRFCCQGYEGNLSDSQATC 127

Human   269 QEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSG- 332
            :..|.|  ||...:..:||.  |||..|:.|..|.:.|....:|.||:..||||||..||..||
  Fly   128 KPICRG--GCGRGSCVMPDI--CSCEEGYIGKHCTQRCDHDRWGLDCKNLCQCQNGAACDNKSGL 188

Human   333 CVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLS 397
            |.|.:||.|..||..  .||         .....|.|..|.....|...:....:::.....|..
  Fly   189 CHCIAGWTGQFCELP--CPQ---------GTYGIMCRKACDCDEKPCNPQTGACIQQDQPLQLNV 242

Human   398 TKAIVEPEKTTAEFE--VPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLT-KQ 459
            :..|||...:|.|..  :||                              |..|:..|.::. ||
  Fly   243 SHVIVETVNSTLEKMGIIPR------------------------------PTTPVPLPEVIVIKQ 277

Human   460 SRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLR---------PKTGY 515
                            |.|.....:.|:        |:|..|.:..|.||.         |:..:
  Fly   278 ----------------PTSNENAQHSPK--------IIVHQSSSDLLENLHTAAAAGVPTPEVIH 318

Human   516 SVRVQLSRPGE------GGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGP 574
            .:...::.|.|      |||.  ......|.|             |..|.....||..|.|:...
  Fly   319 VITNGITSPQEHLAGFVGGEA--NSSQTATAD-------------HQSGLVVTLVSIMLLLLVAI 368

Human   575 LVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTLLG-------PAS 632
            .||..::.|.:       ..:|.:...|...:.|  .|...   :|.|....:||       |..
  Fly   369 AVGSLYVYRRY-------HHKNAAVYNANGTVTT--LPANP---EVVLTEAAVLGKNFHEPLPEP 421

Human   633 PPAHVLLPPSGPPAPRHLHAQALSDSEIQ 661
            |.|..:.|.|....| .|:....::|.|:
  Fly   422 PVAFAVTPQSNEAQP-ELYDSPSNNSSIK 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TIE1	NP_005415.1	ig	129..210	CDD:278476	9/33 (27%)
		EGF_CA	227..256	CDD:238011	8/51 (16%)
		EGF_2	315..344	CDD:285248	16/29 (55%)
		ig	356..441	CDD:278476	12/86 (14%)
		fn3	452..536	CDD:278470	18/99 (18%)
		fn3	548..632	CDD:278470	18/90 (20%)
		FN3	644..736	CDD:238020	4/18 (22%)
		PTKc_Tie1	836..1132	CDD:270671
		TyrKc	839..1107	CDD:197581
NimA	NP_001285918.1	EMI	52..116	CDD:284877	10/63 (16%)
		EGF_2	170..200	CDD:285248	16/29 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000