DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TIE1 and tie1

DIOPT Version :9

Sequence 1:	NP_005415.1	Gene:	TIE1 / 7075	HGNCID:	11809	Length:	1138	Species:	Homo sapiens
Sequence 2:	XP_002931650.3	Gene:	tie1 / 100496664	XenbaseID:	XB-GENE-922217	Length:	1127	Species:	Xenopus tropicalis

Alignment Length:	1140	Identity:	699/1140 - (61%)
Similarity:	853/1140 - (74%)	Gaps:	16/1140 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MVWRVP-PFLLPILFLASHVGAAVDLTLLA-NLRLTDPQRFFLTCVSGEAGAGRGSDAWGPPLLL 63
            ||.|:. ||:.....|:....|.:|:||:: .:||.|   |.|.||:||      .|..|..|.:
Frog     1 MVLRLSLPFVFFFSLLSVKTEAVLDVTLVSLGIRLQD---FALQCVTGE------RDMNGTDLQI 56

Human    64 EKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLL 128
            .:|:.||||......:.| .|:::|..:|| ..|:||||..|.|...|.:|.::||:|:|.|.|:
Frog    57 RRDNSIVRTTHKTHFKTA-IGANEVRAQGF-LISELVGVLICAGKGPAEQTEILYVYNNPNAELI 119

Human   129 PDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIY 193
            |.|||.||:......|.|::.:.:..|::||.||:.|.|....|..|....|.|..|:...:|||
Frog   120 PVKVTVTVSVNSDVTLEAKISRHELADILWKYNGTMFRTTYKGEVTDKTAQLNLQAVKVSQAGIY 184

Human   194 SATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQA 258
            ||.::.||||.:||||||||.|...:|||.|.|:|..||:||:|||..|||:|.|||.|||||:|
Frog   185 SAGFMGASPLSNAFFRLIVRACPDNKWGPSCQKDCLECLNGGICHDSSGECICAPGFMGTRCEKA 249

Human   259 CREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQN 323
            ||||.||::|||.|.|..||:||||||||||||||||||.||.||..|..|.:||:|.|||||:|
Frog   250 CREGNFGRNCQETCKGEQGCKGLTFCLPDPYGCSCGSGWTGSHCQIPCPNGKYGANCALQCQCKN 314

Human   324 GGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELR 388
            ||:|:|||||||||||||.||||||.||||:.:.:.:|.||.:...:.|||:|||.|:|.|||||
Frog   315 GGSCNRFSGCVCPSGWHGQHCEKSDWIPQIIELPNAVEVNLNSSAVLTCAASGNPQPIRESIELR 379

Human   389 KPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAP 453
            :|||:||.::||:::.|::|.||.|..|.|.|:|.|||||||:||||||:|:|:|||||:|:..|
Frog   380 RPDGSVLAASKAVLDRERSTCEFAVQSLTLTDNGLWECRVSTTGGQDSRKFQVHVKVPPLPIEPP 444

Human   454 RLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVR 518
            .||.::|:||.:|||.:|||||||.:::|||:|:|:...|..|||...||:.|..|:|.|.|.:|
Frog   445 LLLDRRSQQLTLSPLHNFSGDGPIISIKLHYKPKDNDSPWKNIVVKQKENIILQKLKPVTSYLIR 509

Human   519 VQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLR 583
            .||||||.||||..||..:|.|||.||.::|.::|..||..:.|.:||:||..  |::|:||||:
Frog   510 AQLSRPGPGGEGPLGPLAVMETDCQEPTVKPVIKGHAVEDRNTLYISWNLPST--PVIGNGFLLQ 572

Human   584 LWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPR 648
            ::.......|:||::|....:..:.||.....|.|.|.:|||..|||.|.|..|.:...||..|:
Frog   573 IYHPENHLIRQENITSMYVLSRKVYGLHANKEYTLKVLIYHCRNLGPPSDPFVVTIHSKGPSPPK 637

Human   649 HLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTR 713
            .|.|:.:|...|:|:|..|:...|.|.||.||.:..|..|:|.|.|.:...:|..||.||||||.
Frog   638 DLRAEPISRDSIKLSWLPPDDPNGGIIKYTVESRPVGIPGEPQWADTENQNQTWHIISGLNASTF 702

Human   714 YLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESR-AAEEGLDQQLILAVVGSVSATCLTIL 777
            |.||:||:.:..|:||.:|:.:.....:.::.|..||: ....|...|||||::||||.||.||:
Frog   703 YQFRVRANSKVPGEWSLSVQSTAHSLEIGSQPPSMESKNPRPSGSSHQLILAIIGSVSITCFTII 767

Human   778 AALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFE 842
            .|||.|.||:::..||||.||||||||||||||||||||||:|||:.|.||.||||||||||.||
Frog   768 LALLALFCIKKNFFHRRRMFTYQSGSGEETILQFSSGTLTLSRRPRPQTEPFSYPVLEWEDIKFE 832

Human   843 DLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGAC 907
            |:||||||||||:|||||||.|||||||||||:||||||||||||||||||||||||||||||||
Frog   833 DVIGEGNFGQVIKAMIKKDGQKMNAAIKMLKEFASENDHRDFAGELEVLCKLGHHPNIINLLGAC 897

Human   908 KNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSE 972
            :|||||||||||||||||||||||||||||||.||:||||||||:|:|||:||||.|.|||||||
Frog   898 ENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPVFAKEHGTASTLTSQQLLQFASDVAKGMQYLSE 962

Human   973 KQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVW 1037
            |||||||||||||||||||.:||||||||||||||||||||||||||||||||||||||||||||
Frog   963 KQFIHRDLAARNVLVGENLVTKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVW 1027

Human  1038 SFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQ 1102
            |||||||||||||||||||||||||||.||||||||:||||||||||||||||||||||||||:|
Frog  1028 SFGVLLWEIVSLGGTPYCGMTCAELYENLPQGYRMEKPRNCDDEVYELMRQCWRDRPYERPPFSQ 1092

Human  1103 IALQLGRMLEARKAYVNMSLFENFTYAGIDATAEE 1137
            |::||.|||:||||||||:||||||||||||||||
Frog  1093 ISIQLTRMLDARKAYVNMALFENFTYAGIDATAEE 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TIE1	NP_005415.1	ig	129..210	CDD:278476	32/80 (40%)
		EGF_CA	227..256	CDD:238011	18/28 (64%)
		EGF_2	315..344	CDD:285248	23/28 (82%)
		ig	356..441	CDD:278476	46/84 (55%)
		fn3	452..536	CDD:278470	45/83 (54%)
		fn3	548..632	CDD:278470	30/83 (36%)
		FN3	644..736	CDD:238020	38/91 (42%)
		PTKc_Tie1	836..1132	CDD:270671	272/295 (92%)
		TyrKc	839..1107	CDD:197581	247/267 (93%)
tie1	XP_002931650.3	IG_like	124..203	CDD:214653	31/78 (40%)
		EGF_CA	<222..247	CDD:238011	17/24 (71%)
		EGF_CA	306..336	CDD:238011	24/29 (83%)
		Ig	341..432	CDD:416386	50/90 (56%)
		Ig strand A	341..345	CDD:409353	3/3 (100%)
		Ig strand A'	351..355	CDD:409353	1/3 (33%)
		Ig strand B	358..367	CDD:409353	3/8 (38%)
		Ig strand C	375..380	CDD:409353	4/4 (100%)
		Ig strand C'	384..386	CDD:409353	0/1 (0%)
		Ig strand D	390..394	CDD:409353	2/3 (67%)
		Ig strand E	397..405	CDD:409353	3/7 (43%)
		Ig strand F	413..421	CDD:409353	6/7 (86%)
		Ig strand G	424..432	CDD:409353	6/7 (86%)
		fn3	448..511	CDD:394996	30/62 (48%)
		FN3	633..724	CDD:238020	38/90 (42%)
		PTKc_Tie1	826..1122	CDD:270671	272/295 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	518	1.000	Domainoid score	I3455
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3957
Inparanoid	1	1.050	1412	1.000	Inparanoid score	I1593
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43836
OrthoDB	1	1.010	-	-		D22921at32523
OrthoFinder	1	1.000	-	-		FOG0006344
OrthoInspector	1	1.000	-	-		oto149677
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11087
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080