DRSC/TRiP Functional Genomics Resources

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Protein Alignment TIAM1 and CDC24

DIOPT Version :10

Sequence 1:NP_003244.2 Gene:TIAM1 / 7074 HGNCID:11805 Length:1591 Species:Homo sapiens
Sequence 2:NP_009359.1 Gene:CDC24 / 851190 SGDID:S000000039 Length:854 Species:Saccharomyces cerevisiae


Alignment Length:821 Identity:164/821 - (19%)
Similarity:288/821 - (35%) Gaps:230/821 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   822 PQPEED----IYELLYKEIEICPKVTQSIHI--EKSDTAADTYGFSLSSVEEDGIRRLYVNSVKE 880
            |..|:|    |...:.|.:|:.|::...:.:  :.|:..::.....||.                
Yeast    36 PVTEQDSLFHICANIRKRLEVLPQLKPFLQLAYQSSEVLSERQSLLLSQ---------------- 84

Human   881 TGLASKKGLKAGDEILEIN--NR----AADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLES 939
                     |...|:|:.|  ||    .|..|.||.:....|..|:           ||:....|
Yeast    85 ---------KQHQELLKSNGANRDSSDLAPTLRSSSISTATSLMSM-----------EGISYTNS 129

Human   940 PPHRVDGPAD------LGESPLAFLTSNPGHSLCS--EQGSSA----ETAPEETEGPDLESSD-- 990
            .|.......|      :|..|:. :..:|...|..  :||:..    .:...:.:.|.:.|.|  
Yeast   130 NPSATPNMEDTLLTFSMGILPIT-MDCDPVTQLSQLFQQGAPLCILFNSVKPQFKLPVIASDDLK 193

Human   991 --------------------------ETDHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTGPQL 1029
                                      .:|..:.||.|:......:..:..|..:..|..|...|:
Yeast   194 VCKKSIYDFILGCKKHFAFNDEELFTISDVFANSTSQLVKVLEVVETLMNSSPTIFPSKSKTQQI 258

Human  1030 AT-----MRQLSDADKLR----KVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLF 1085
            ..     ..|...:.|..    |:|.|.:.|||.||.||. ::::|.:.|.....:|.:||.:||
Yeast   259 MNAENQHRHQPQQSSKKHNEYVKIIKEFVATERKYVHDLE-ILDKYRQQLLDSNLITSEELYMLF 322

Human  1086 GNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFC---- 1146
            .||.:.::||..||.:||....:.|..::             :|..|::....||||..:.    
Yeast   323 PNLGDAIDFQRRFLISLEINALVEPSKQR-------------IGALFMHSKHFFKLYEPWSIGQN 374

Human  1147 ASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAES 1211
            |:...:...|.|.:.|.:.:..:   |.|.:    |:|:|.||:||:.:||||::||.| ..::.
Yeast   375 AAIEFLSSTLHKMRVDESQRFII---NNKLE----LQSFLYKPVQRLCRYPLLVKELLA-ESSDD 431

Human  1212 EEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEK---KEVADLSMGDLLLHTTV 1273
            .....|:.|:.....:|..|||.|:..|.     .|::.:..|..   |.......|:||....|
Yeast   432 NNTKELEAALDISKNIARSINENQRRTEN-----HQVVKKLYGRVVNWKGYRISKFGELLYFDKV 491

Human  1274 IWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQ-------KKKLVGSHRLSIYEDWD---- 1327
            ......:|.   :.|.|...::|:..::|..:..:|:       |||...|..:|.....|    
Yeast   492 FISTTNSSS---EPEREFEVYLFEKIIILFSEVVTKKSASSLILKKKSSTSASISASNITDNNGS 553

Human  1328 ---PFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSES------EGRPERVFHLCCSSP--- 1380
               .:..||...:.:..:. |:|:.|.|     |:|..:.|      ......:|.|..:.|   
Yeast   554 PHHSYHKRHSNSSSSNNIH-LSSSSAAA-----IIHSSTNSSDNNSNNSSSSSLFKLSANEPKLD 612

Human  1381 -------------------------ESRKD---FL-----------------KAVHSILRDKHRR 1400
                                     ||.|:   ||                 :.:|.:..::.:.
Yeast   613 LRGRIMIMNLNQIIPQNNRSLNITWESIKEQGNFLLKFKNEETRDNWSSCLQQLIHDLKNEQFKA 677

Human  1401 QLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGRRRRRLARNRFTIDSDA-VSA 1464
            :...:.|..||                  .|.|.::.:|:.::......  .:|.|.||.| .|:
Yeast   678 RHHSSTSTTSS------------------TAKSSSMMSPTTTMNTPNHH--NSRQTHDSMASFSS 722

Human  1465 SSPEKESQQPPGGGDTDRWVEEQFDLAQYEEQDDIKETDIL 1505
            |..::.|...|....|....|.:........::.|.|:.||
Yeast   723 SHMKRVSDVLPKRRTTSSSFESEIKSISENFKNSIPESSIL 763

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TIAM1NP_003244.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..379
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 393..422
PH1_Tiam1_2 432..558 CDD:269937
Tiam_CC_Ex 572..669 CDD:408184
Ubl1_cv_Nsp3_N-like 766..832 CDD:475130 4/13 (31%)
PDZ 858..>901 CDD:214570 6/44 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..1034 20/139 (14%)
RhoGEF 1044..1233 CDD:214619 55/192 (29%)
PH2_Tiam1_2 1235..1406 CDD:269957 39/241 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1456..1482 9/26 (35%)
CDC24NP_009359.1 CDC24 156..242 CDD:399412 11/85 (13%)
RhoGEF 282..453 CDD:214619 55/192 (29%)
PH_Scd1 455..667 CDD:270066 38/225 (17%)
PB1 779..853 CDD:214770
Blue background indicates that the domain is not in the aligned region.

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