Protein Alignment TIAM1 and tiam1

DIOPT Version :10

• Sequence 1: NP_003244.2
• Gene: TIAM1 / 7074
• HGNCID: 11805
• Length: 1591
• Species: Homo sapiens
• Sequence 2: XP_002938487.1
• Gene: tiam1 / 734013
• XenbaseID: XB-GENE-1006478
• Length: 1590
• Species: Xenopus tropicalis
• Alignment Length: 1606
• Identity: 1244/1606 - (77%)
• Similarity: 1383/1606 - (86%)
• Gaps: 31/1606 - (1%)

Human     1 MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHK-TRRTRHASSGKVIHRNSEVSTRSSSTPSI 64
            |||||||:||...||::|.:|||||||||||:|:| :||||||||||.:|||||||.||||||||
 Frog     1 MGNAESQNVEQALYGKEHGTLGRKHTSRSLRISNKNSRRTRHASSGKPVHRNSEVSNRSSSTPSI 65

Human    65 PQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSY-TDSSVTPSVDSSIVLTAASVQSMPD 128
            ||||||||:||:|||..|:||.|..|   |||||||||| ||||||||::||.||||||:|||.|
 Frog    66 PQSLAENGMEPYSQDANLDDFDSRDW---VDMGLRPVSYHTDSSVTPSLNSSTVLTAASMQSMQD 127

Human   129 TEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETASFKKKRSKSADIWREDSLEFSLSDLSQEHL 193
            .|||||||:|.:|..:|..|...||:|||..::.|||||||||||||||||||||||||||||||
 Frog   128 CEESRLYGEDHSYFQDGNGRSQIYTTNGPNLLDAASFKKKRSKSADIWREDSLEFSLSDLSQEHL 192

Human   194 TSNEEILGSAEEKDCEEARGMETRASPRQLSTCQRANSLGDLYAQKNSGVTANGGPGSKFAGYCR 258
            ||.||||.|.|||||||....|. .:..:|::.||||||.|||.|.|...:.||.|.|||..|||
 Frog   193 TSTEEILCSTEEKDCEETIIAEA-GNNAKLNSSQRANSLTDLYPQINPHASVNGAPRSKFMVYCR 256

Human   259 NLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEGATNPQISHSNSMQGRRAKTTQDV 323
            ||||..|...|:||.|.:||||||||||:||||||||||||||.|.::||:|||.||||||||||
 Frog   257 NLVSHSPESENYKMDPTSAEETPPYSNYSTLPCRKSHCLSEGAANLKLSHTNSMHGRRAKTTQDV 321

Human   324 N-AGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPTTGRAFVGSDSGSSSTGDAARQGVYENF 387
            | .||||||.|||||.||||||::|||||.|.||||||..|.|:|||||||||||..||||||||
 Frog   322 NTGGEGSEFTDSGIEAATTDTDIISRRSNITTSSYSPTASRVFIGSDSGSSSTGDVLRQGVYENF 386

Human   388 RRELEMSTTNSESLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQGTVRKAGALAVKNFLVHKKNK 452
            |||||||..:.|:||||.||.||||||||||||||||||||||||||||||||||||||||||||
 Frog   387 RRELEMSRASRENLEEASSALSDEQSSGTLSSPGQSDILLTAAQGTVRKAGALAVKNFLVHKKNK 451

Human   453 KVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCL 517
            |||.|||||||.||||||||||||||:|||||||:||||||||||||||||||||||||||||||
 Frog   452 KVEPATRRKWKQYWVSLKGCTLFFYETDGRSGIDNNSIPKHAVWVENSIVQAVPEHPKKDFVFCL 516

Human   518 SNSLGDAFLFQTTSQTELENWITAIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKK 582
            |||||||||||||||||||||||||||||||.|||.||||||::|||||||||||||||||||||
 Frog   517 SNSLGDAFLFQTTSQTELENWITAIHSACATTVARQHHKEDTVKLLKSEIKKLEQKIDMDEKMKK 581

Human   583 MGEMQLSSVTDSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPT 647
            |||||:|||||:||||||||||||||||||||||||||:||||:|||||||||||||||||||||
 Frog   582 MGEMQISSVTDAKKKKTILDQIFVWEQNLEQFQMDLFRYRCYLSSLQGGELPNPKRLLAFASRPT 646

Human   648 KVAMGRLGIFSVSSFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPSI 712
            |||||||||||||||||||||||||:||||||||||||||||||||||||||||:|||||||.|:
 Frog   647 KVAMGRLGIFSVSSFHALVAARTGESGVRRRTQAMSRSASKRRSRFSSLWGLDTSSKKKQGRTSV 711

Human   713 NQVFGEGTEAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDIWVHEYFTPSWFCLPNNQPA 777
            .|||.:|:|:||||||||||:.:.:.|:||||.|..||.||||.|||||:|.||||.||||:||.
 Frog   712 TQVFSDGSESVKKSLEGIFDETMSEEKKEKEVALSTVHPHNPDTDIWVHDYLTPSWVCLPNDQPV 776

Human   778 LTVVRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQPEEDIYELLYKEIEICPKV 842
            |.|:.|.|.|:|.||:||||||||::::|||||||::|:.|:|:|:|||:|||||||||||||||
 Frog   777 LIVIHPDDMAKDALEIICKTHQLDYTSYYLRLKFLMDNQTQIYIPKPEEEIYELLYKEIEICPKV 841

Human   843 TQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEINNRAADALN 907
            |:.|.:||...|::::||:||||||||...||||:|||:|||.|||||.|||::|||.:.|..||
 Frog   842 TKHIQLEKGGGASESFGFALSSVEEDGRHHLYVNNVKESGLAYKKGLKVGDEVMEINAKPARELN 906

Human   908 SSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADLGESPLAFLTSNPGHSLCSEQGS 972
            ||:||:.|.:.||.|.|||.|  :.|...||:.|.|.|  .|..:   ..|.||..   |||..|
 Frog   907 SSVLKNILCKSSLYLTVRTCP--DAGDCPLEALPRRSD--TDCND---FLLLSNRD---CSETDS 961

Human   973 SAETAPEETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTGPQLATMRQLSD 1037
            .:||||||.| ..|::.:|.|..:||||||||..||.||||..|...||.:..||.|||||||:|
 Frog   962 CSETAPEEIE-VQLDAPEEADSINKSTEQVAALRRSPHEMNSPDSCLSPSEFAGPALATMRQLTD 1025

Human  1038 ADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTL 1102
            ||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||
 Frog  1026 ADKLRKVICELLETERTYVKDLNCLMERYLKPLQKEPFLTQDELDVLFGNLTEMVEFQVEFLKTL 1090

Human  1103 EDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKA 1167
            ||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||:.|||
 Frog  1091 EDGVRLVPDLEKLEKVEQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDSNFKA 1155

Human  1168 FLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHIN 1232
            |||||||||||||||||||||||||||||||||:||::|||||||||||||||||||||||||||
 Frog  1156 FLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLKELYSLTDAESEEHYHLDVAIKTMNKVASHIN 1220

Human  1233 EMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFK 1297
            ||||||||:||||||||:||:||.||||||||||||||.||.|||||||||||||:||||.||||
 Frog  1221 EMQKIHEEYGAVFDQLISEQSGEVKEVADLSMGDLLLHNTVTWLNPPASLGKWKKDPELATFVFK 1285

Human  1298 TAVVLVYKDGSKQKKKLVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVK 1362
            |||||||||.|||||||.||||.|::||.|||||||||||||||||.:.::|||.|:||||||||
 Frog  1286 TAVVLVYKDSSKQKKKLGGSHRASMFEDRDPFRFRHMIPTEALQVRTMTTSDAETNSVCEIVHVK 1350

Human  1363 SESEGRPERVFHLCCSSPESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKG 1427
            |||||||||.||||||:|..:|:||:|||||||||||||||||||||:|||||||||||||||||
 Frog  1351 SESEGRPERAFHLCCSNPGRKKEFLRAVHSILRDKHRRQLLKTESLPNSQQYVPFGGKRLCALKG 1415

Human  1428 ARPAMSRAVSAPSKSLGRRRRRLARNRFTIDSDAVSASSPEKESQQ-----PP----GGGDTDRW 1483
            |||.|:|||||||:||. |||||.|||||||||::.::.|||:|.|     ||    ..||||||
 Frog  1416 ARPTMNRAVSAPSRSLA-RRRRLVRNRFTIDSDSIFSNDPEKDSDQETEPSPPQQSSNSGDTDRW 1479

Human  1484 VEEQFDLAQYEEQDDIKETDILSDDDEFCESVKGASVDRDLQERLQATSISQRERGRK---TLDS 1545
            |||||||||||||||:|||||||.|||:|||:||.|:::||.|:|:|||:|....|.|   |:::
 Frog  1480 VEEQFDLAQYEEQDDVKETDILSSDDEYCESIKGGSMEKDLSEQLEATSLSSNPMGTKVQNTMNT 1544

Human  1546 HASRMAQLKKQAALSGINGGLESASEEVIWVRREDFAPSRKLNTEI 1591
            |||||||||||.|.||:||.:||.::|||||:||||.|.|||||||
 Frog  1545 HASRMAQLKKQTAFSGMNGSIESNTDEVIWVKREDFVPVRKLNTEI 1590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TIAM1	NP_003244.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78		60/77 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..379		63/81 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..422		21/28 (75%)
		PH1_Tiam1_2	432..558	CDD:269937	119/125 (95%)
		Tiam_CC_Ex	572..669	CDD:408184	92/96 (96%)
		Ubl1_cv_Nsp3_N-like	766..832	CDD:475130	42/65 (65%)
		PDZ	858..>901	CDD:214570	31/42 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..1034		44/94 (47%)
		RhoGEF	1044..1233	CDD:214619	181/188 (96%)
		PH2_Tiam1_2	1235..1406	CDD:269957	142/170 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1456..1482		15/34 (44%)
tiam1	XP_002938487.1	PH1_Tiam1_2	431..557	CDD:269937	119/125 (95%)
		Tiam_CC_Ex	571..668	CDD:408184	92/96 (96%)
		RBD	765..838	CDD:460485	49/72 (68%)
		PDZ	841..924	CDD:214570	48/82 (59%)
		RhoGEF	1032..1221	CDD:214619	181/188 (96%)
		PH2_Tiam1_2	1223..1394	CDD:269957	142/170 (84%)