DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TIAM1 and sif

DIOPT Version :10

Sequence 1:NP_003244.2 Gene:TIAM1 / 7074 HGNCID:11805 Length:1591 Species:Homo sapiens
Sequence 2:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster


Alignment Length:1710 Identity:525/1710 - (30%)
Similarity:779/1710 - (45%) Gaps:384/1710 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    15 GEKHASLGRKHTSRSLRLSHKTRR-------TRHASS-----GKVIHRNSEVSTRSSSTPSIPQS 67
            |..|.|:|   |..|......||.       ||.|.|     ..||:.|:...|:|:...::..|
  Fly   333 GGLHQSVG---TCTSSSKGTGTRNKDFGDDMTRDAHSHDMHQHNVINNNTRRKTKSTEDMNVDTS 394

Human    68 LAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTDSSVTPSVDSSIVLTAASVQSMPDTEES 132
            ..:..|:|      :....||  |...:||.|..:|              ..|.:.|::......
  Fly   395 TLKRMLKP------MPSTESP--VTSPEMGRRRYNY--------------YNANAAQTLGHPPHM 437

Human   133 RLYGDDATYLAEGGRRQHSYTSN--GPTFMETASFKKKRSKSADIWR------------------ 177
            ..:|........||...|...:|  |....:::.|...|| |.:|.|                  
  Fly   438 HQHGMAMGMGGGGGGGHHIMNNNTMGRASSQSSRFSGSRS-SHEIGRGYPPRNLYLELERERSCI 501

Human   178 -----EDSLEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETRAS--PRQLSTCQRANSLGDL 235
                 .|::.|.    :|.:.|:.....|::::   :::.|.:..:.  |:|.....:.:|....
  Fly   502 EGSPPSDNVMFD----NQCYATTPSSSNGNSDQ---DQSYGQQQSSGQHPQQQQGPPQRSSRHQH 559

Human   236 YAQKNSGVTAN-GGPGSK----FAGYCRN-------------------LVSDIPNL--------A 268
            :.|:...||.. |.|.|:    :..:.||                   |...:.||        :
  Fly   560 HHQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQSMENLEFAESLPGS 624

Human   269 NHKMP-----PAAAEET---PP-------------------YSNYNTL----------------- 289
            |.:.|     |.|...|   ||                   ||:.|.|                 
  Fly   625 NQRSPYPLRRPNAKSSTLPLPPHRPLSTIRDKERDRDRDGYYSDRNELIRERERERDRGYLSDHN 689

Human   290 ----PCRKSHCLSEGATNPQISHSN----------SMQGRRAKTTQDVNAG-------------E 327
                ..|.:.|:.|.|......||:          |..|....|.|...:|             :
  Fly   690 SSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQ 754

Human   328 GSEFADSGIEGATTDTDLLSRRSNATNSSYSPTTGRAFVGSDSGSSS--TGDAARQGVYEN---- 386
            .|...|||.:.|..|:  |.:|:.             |:..||..|.  :...:|.|:.:.    
  Fly   755 DSSLNDSGYKSARADS--LEQRAE-------------FIRQDSLRSEYLSDRESRYGIVQQASIE 804

Human   387 -------FRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQ-----GTVRKAGA 439
                   :....|:|..:..||..|.|...|.:|  .::||.::....|||.     |.|||||.
  Fly   805 STDSRMCYLTSSEISDDDRMSLTTAVSDEDDGES--VMASPYKAKATGTAASSFNCTGAVRKAGF 867

Human   440 LAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSIVQA 504
            |:||.:|:.||: ::|.|.:|.||.|||.|||.||.||..|.|.|....:.|||.:.|:.:|:|.
  Fly   868 LSVKKWLLRKKH-QIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQP 931

Human   505 VPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACATAVARHHHKEDTLRLLKSEIKK 569
            :|||||:|::||||.:.|||:|||...|.|||||:.:||||||.|.|||..|..||.||:.||.:
  Fly   932 IPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFR 996

Human   570 LEQKIDMDEKMKKMGEMQLSSVTDSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELP 634
            ||:.|:.|.|:|.|.|:|.|.|||.:.:..|..||..||:|||:...:.||.|||:||||.||||
  Fly   997 LEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELP 1061

Human   635 NPKRLLAFASRPTKVAMGRLGIFSVSSFHALVAART---------GETGVRRRTQAMSRSASKRR 690
            |||.||...|||||..:.:||:|:||||||.:.||:         |....:||...:|||.|   
  Fly  1062 NPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNS--- 1123

Human   691 SRFSSLWGLDTTSKKKQGRPSINQVFGEGTEAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPD 755
                   |....|.:...|....:.|.                                      
  Fly  1124 -------GSSRRSMQMNSRDEPEKTFK-------------------------------------- 1143

Human   756 CDIWVHEYFTPSWFCLPNNQPALTVVRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLY 820
                         ..:|:|..:...:|...:..:.|...|....|:...|::|:|...:.:...|
  Fly  1144 -------------VAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNY 1195

Human   821 -VPQPEEDIYELLYKE--IEICPKVTQSIHIEKSDTAADTYGFSLSSVEEDGIRR-----LYVNS 877
             ||...:.|...|:..  :|:|.|:...:.:::: |....:|||:.:...:...|     .||:.
  Fly  1196 FVPHRNDLIENYLHNHEFVEVCMKILYQVELQRT-TLEQMWGFSVEAELIENAERQDELCCYVSR 1259

Human   878 VKETGLASKKGLKAGDEILEINNRAADALNSSMLKDFL-SQPSLGLLVRTY----PEL------- 930
            |::..:|...|:..||||:.||......|:...|:..| .:.||.:::|:.    |:|       
  Fly  1260 VEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVT 1324

Human   931 EEGVELLESPPHRVDGPADLGESPLAFLTSNPGHSLCSEQGSSAET-APEETEGP---------- 984
            ::.::.|..||...|.|....|.....:...||.:     |:|.:. :||....|          
  Fly  1325 DDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWN-----GTSKDLYSPEAESSPATSFVDPAAM 1384

Human   985 -----------------------DLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTG 1026
                                   ...||.|.::..|:.||      ...:.:|:....|...:|.
  Fly  1385 AAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQ------ETRKSSPTGSVTSSVSTTA 1443

Human  1027 PQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEM 1091
              |...|||:||:|||||:.||::|||||||.||.|:|.||:|:::||||:..|::.||||:.|:
  Fly  1444 --LTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEI 1506

Human  1092 VEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVL 1156
            |.||.:||:.||:.:.|.||..|.|...||:.|||::|.:||||.:.|||||:|||||:|..|||
  Fly  1507 VTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVL 1571

Human  1157 VKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAI 1221
            ...:.:.|.:.||.|:||||||||||||||||||||||||||||:::..|||..::||.||..|:
  Fly  1572 HPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEAL 1636

Human  1222 KTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWK 1286
            |.|.|||.||||||:||||:||:||.|..:.....|:..|||.||||.:..|.|||....|||.|
  Fly  1637 KGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIK 1701

Human  1287 KEPELAA--FVFKTAVVLVYKDGSKQKKKLVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASAD 1349
            |..||.|  ||||:|||.:.|:..:|||||:|....:...:.:..|::.:||...:||||.::.|
  Fly  1702 KGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKD 1766

Human  1350 AEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQY 1414
            .:::.:.|::|::|:.:.|.|:|:.|..|:.:.|..|||.:..|:|:..|..     |:|...  
  Fly  1767 MDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNM-----SIPMKN-- 1824

Human  1415 VPFGGKRLCALKG---------ARPAMSRAVSAP---------SKSLGRRRRRLARNRFT---ID 1458
              |||.. .::.|         ..|..|:.:..|         |.:||:.:::....|.:   ||
  Fly  1825 --FGGSS-GSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNID 1886

Human  1459 SDAVSASSPEKESQQPPGGG 1478
            .|.:|.|  ::....||..|
  Fly  1887 YDNLSGS--QEADDLPPSVG 1904

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TIAM1NP_003244.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78 20/74 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..379 21/105 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 393..422 9/28 (32%)
PH1_Tiam1_2 432..558 CDD:269937 69/125 (55%)
Tiam_CC_Ex 572..669 CDD:408184 51/96 (53%)
Ubl1_cv_Nsp3_N-like 766..832 CDD:475130 13/66 (20%)
PDZ 858..>901 CDD:214570 15/47 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..1034 22/128 (17%)
RhoGEF 1044..1233 CDD:214619 110/188 (59%)
PH2_Tiam1_2 1235..1406 CDD:269957 67/172 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1456..1482 8/26 (31%)
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 69/125 (55%)
Tiam_CC_Ex 999..1096 CDD:408184 51/96 (53%)
RBD 1141..1207 CDD:128731 14/116 (12%)
PDZ 1220..1299 CDD:214570 19/79 (24%)
RhoGEF 1456..1647 CDD:238091 112/190 (59%)
PH2_Tiam1_2 1650..1823 CDD:269957 69/177 (39%)
PHA03307 2227..>2510 CDD:223039
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.