DRSC/TRiP Functional Genomics Resources

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Protein Alignment TIAM1 and GEFmeso

DIOPT Version :10

Sequence 1:NP_003244.2 Gene:TIAM1 / 7074 HGNCID:11805 Length:1591 Species:Homo sapiens
Sequence 2:NP_788403.2 Gene:GEFmeso / 37134 FlyBaseID:FBgn0050115 Length:1549 Species:Drosophila melanogaster


Alignment Length:818 Identity:186/818 - (22%)
Similarity:304/818 - (37%) Gaps:196/818 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   838 ICPKVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEINNR- 901
            :|.:....:.|      .||..|.           |....::...||....|....|::|..|: 
  Fly   348 VCSEPLSPVDI------VDTINFD-----------LVAQHMERLTLADPGDLDPRAELIEAVNKT 395

Human   902 -------------AADALNSSMLKDFLSQPSLGLLVRT--------YPELEEGVELLES---PPH 942
                         .|..:.||.|..:....|||....|        .|..|:..||.|:   ...
  Fly   396 LVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAE 460

Human   943 RVDGPADLGE------SPLAFLTSNP--GHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKST 999
            .:|...|:..      |.||.|.:.|  ..|:||...||:..:.:...|..:.:|        ..
  Fly   461 SLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATS--------YL 517

Human  1000 EQVAAFCRSLHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLME 1064
            ..|.:...|.:|:  .||...|..|.               |.|...|::::||::|:||..:::
  Fly   518 ASVESLAESENEL--GDQHHPPAMSV---------------LEKTCLEIVDSERSFVEDLGQVIK 565

Human  1065 RYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLG 1129
            .||:..::...|..|||.:||.|:.|:.||....|:.|.:..|   |..::.:            
  Fly   566 GYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGR---DPGRIAR------------ 615

Human  1130 GSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRIL 1194
             .|:...|.|.:|:.:|.|:.:...:|.|....|...:.|.:.....||...|.|||:||:||||
  Fly   616 -CFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRIL 679

Human  1195 KYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEV 1259
            ||.|||..|....|.:.....|:     .|.:||.:|:::::..            ||....||:
  Fly   680 KYHLLLDSLRKHCDVKEVVEAHV-----IMRQVAHNIDQVKRKQ------------EQQSRVKEL 727

Human  1260 ADLSMGDLLLHTTVIWLNPPAS-LGKWKKEPELAAFVFKTAVVLVY----------KDGSKQKKK 1313
            :.:..|         ||.|..: ||:.::|..|.....|..:||::          :||..|.|.
  Fly   728 SGILDG---------WLGPELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKT 783

Human  1314 LVGSHRLSIYE--DWDPFRF--------RHMIP------------TEALQVRALASADAEANAVC 1356
            .:..:.|.:.|  ..:|..|        ||.|.            |:.::...|...|....|..
  Fly   784 YISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKE 848

Human  1357 EIVHVKSESEGRPER-----VFHLCCSSPESRKDFLKAVHSILRD--KHRRQLLKTESLPSSQQY 1414
            .:..:.:|.:..|:|     ..|   |...|...:|:..::..|.  :.|....|.:::.:|..:
  Fly   849 LVYQLGNEEDRTPDRSTWKWSLH---SGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSF 910

Human  1415 VPFGGKRLCALKGARPAMSRAVSAPSKSLGRR--------RRRLARNRFTIDSDAVSASSPEKES 1471
            ..|..    :|:....::|:|  .|||.|.|.        ::..|..|:.....||      ||.
  Fly   911 DSFNE----SLEQEEESISQA--KPSKPLARNNSLDDTALQKLAAAMRYRKRDAAV------KEE 963

Human  1472 QQPPGGGDTDRWVEEQFDLAQYEEQDDIKETDILSDDDEFCESVKGAS---VDRDLQERLQATSI 1533
            .:.|        |:|.....|..:||:..|.......|:...|.|..|   ..:.|:||    |.
  Fly   964 TKTP--------VKEPCKCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKER----SK 1016

Human  1534 SQRERGRKTLDSHASRMAQLKKQAALSGINGGLESASE 1571
            |....|..:||..|.|..:..:.:|.| :.|.....||
  Fly  1017 SVPRIGGFSLDEEAEREREQDEDSAAS-LRGSKPDLSE 1053

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TIAM1NP_003244.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..379
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 393..422
PH1_Tiam1_2 432..558 CDD:269937
Tiam_CC_Ex 572..669 CDD:408184
Ubl1_cv_Nsp3_N-like 766..832 CDD:475130
PDZ 858..>901 CDD:214570 7/42 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..1034 21/105 (20%)
RhoGEF 1044..1233 CDD:214619 56/188 (30%)
PH2_Tiam1_2 1235..1406 CDD:269957 40/210 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1456..1482 5/25 (20%)
GEFmesoNP_788403.2 RhoGEF 548..712 CDD:459876 55/184 (30%)
PH_PLEKHG1_G2_G3 694..839 CDD:270063 33/170 (19%)
Blue background indicates that the domain is not in the aligned region.

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