DRSC/TRiP Functional Genomics Resources

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Protein Alignment TIAM1 and CG15611

DIOPT Version :10

Sequence 1:NP_003244.2 Gene:TIAM1 / 7074 HGNCID:11805 Length:1591 Species:Homo sapiens
Sequence 2:NP_611189.2 Gene:CG15611 / 36930 FlyBaseID:FBgn0034194 Length:508 Species:Drosophila melanogaster


Alignment Length:558 Identity:120/558 - (21%)
Similarity:216/558 - (38%) Gaps:156/558 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   899 NNRAADALNSSMLKD---FLSQPSLGLLVRTYP--------ELEEGVELLESPPHRVDGPADL-- 950
            |.::.|.::.:..|:   ..||.....:..|.|        :||:.:.||:|     |....|  
  Fly    42 NGKSIDVVDKAPAKECPLLESQSPSSPIATTLPKSQASSNGKLEKQISLLDS-----DSGISLSS 101

Human   951 ---------GESPLAFLTSNPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKSTEQVAAFC 1006
                     ..|| .:...|..||..|      .|...||.|.:....::|              
  Fly   102 INTCSTTAANSSP-TYRAPNGFHSFPS------HTLSFETLGDEYHEDEDT-------------- 145

Human  1007 RSLHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERY--LKP 1069
            .||..:.|.||:               ::..:.|:..:|.||::||..||.:|...|..|  ||.
  Fly   146 LSLENLFPCDQT---------------EIYASKKISFIIDELIQTEVNYVNNLKKGMLNYGQLKD 195

Human  1070 LQ--KETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSF 1132
            ::  .|....:.:..:|.||:.|::|...:         .::|.:.:.::         .|.|.|
  Fly   196 VEDLPEALSGETKQKMLLGNIKEILELHEK---------EILPLMLRNQR---------DLKGLF 242

Human  1133 LYYADRFKLYSAFC-ASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKY 1196
            ..:|..|:..|.:| .|.|...|..::.:.|.  :.:|.....:.:....::|:|::||||:.:|
  Fly   243 DEFAAHFEKNSFYCYVSFTMGKKSSMQLRQDN--RLWLQTYQTQIKDKLGIDSFLVQPIQRLTRY 305

Human  1197 PLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVAD 1261
            ||||::..:       |.|...::.|.:      :..:.|:........|  :..|..|...:.:
  Fly   306 PLLLQQFIS-------EFYKSGISCKPV------LTAVCKLETRMRRALD--VVNQAEEIPNIEE 355

Human  1262 LSMGDLLLHTTVIWLNPPASLGKWKKEPELAA-------------FVFKTAVVLVYKDGSKQKKK 1313
            |:..|:|            .||.:::..|..|             |:|...:|..    ..:||:
  Fly   356 LNELDVL------------QLGNFRRATEFDAQHFPTRKKYRSKVFLFDRCLVCT----EVRKKR 404

Human  1314 LVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSE----SEGRPERVFH 1374
            |  ::|.  :.:|:     |:    .|| |.|.|..:.||.:..:: ||.|    |.|.....:.
  Fly   405 L--AYRQ--HYNWE-----HV----ELQ-RPLDSVSSNANKIINLL-VKQEEGGSSVGSKREEYS 454

Human  1375 LCCSSPESRKDFLKAVHSIL---RDKHRRQLLKTESLP 1409
            ...:.....|.:|:|.|.|:   |::|.|:  .|.|||
  Fly   455 FMAAEASVVKQWLQATHKIIEIARNEHARR--NTFSLP 490

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TIAM1NP_003244.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..379
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 393..422
PH1_Tiam1_2 432..558 CDD:269937
Tiam_CC_Ex 572..669 CDD:408184
Ubl1_cv_Nsp3_N-like 766..832 CDD:475130
PDZ 858..>901 CDD:214570 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..1034 19/105 (18%)
RhoGEF 1044..1233 CDD:214619 45/193 (23%)
PH2_Tiam1_2 1235..1406 CDD:269957 40/190 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1456..1482
CG15611NP_611189.2 RhoGEF 167..313 CDD:470622 42/165 (25%)
Blue background indicates that the domain is not in the aligned region.

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