DRSC/TRiP Functional Genomics Resources

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Protein Alignment TIAM1 and RtGEF

DIOPT Version :10

Sequence 1:NP_003244.2 Gene:TIAM1 / 7074 HGNCID:11805 Length:1591 Species:Homo sapiens
Sequence 2:NP_001097184.2 Gene:RtGEF / 35306 FlyBaseID:FBgn0015803 Length:1310 Species:Drosophila melanogaster


Alignment Length:659 Identity:143/659 - (21%)
Similarity:237/659 - (35%) Gaps:219/659 - (33%)


- Green bases have known domain annotations that are detailed below.


Human  1023 DSTG--------------PQLATMRQLSDADKLRKVIC-ELLETERTYVKDLNCLMERYLKPLQK 1072
            |.||              |...|:|...:..:.|.|:. :||::||.:|.:|..|:|.:|:|:|:
  Fly    46 DKTGWFPSNYVNECKVQLPLTETIRPPEEIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQ 110

Human  1073 ETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYAD 1137
            ...|:|||...|..|.       ||.::|.||   |:..:|:...         .:|..||..|.
  Fly   111 TQILSQDEYAQLMCNF-------VEIVRTHED---LLIQIEECND---------RVGKLFLTSAP 156

Human  1138 RF-KLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLR 1201
            .. |::.|:||:|.|...:|.|.|.:  .:.:::.|.........|.:.|.||.:|:.||..:|:
  Fly   157 LMKKVHQAYCAAHPKAIVILDKYKDE--LEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQ 219

Human  1202 ELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFG------AVFDQLIA--EQTGEKKE 1258
            ||        |.|                   |:..|.:.|      ||:..:.|  ..|..:||
  Fly   220 EL--------ERH-------------------MESSHPDRGDTQRSVAVYKDIAATCSATRRQKE 257

Human  1259 V--------------ADLS-MGDLLL---------HTTVIWLNPPASLGKWKKEPELAAFVFK-- 1297
            :              .:|| :||::.         |....::..|.:|........::||:::  
  Fly   258 LELQVLTGPVRGWQGQELSTLGDIIHMGSVAVGADHRDRYFVLFPQTLLFLSVSQRMSAFIYEGK 322

Human  1298 ---TAVVLVYKDGSKQKKKLVGSHRLSIYEDWDPFRFRHMIPTEAL-QVRALASADAEANAVCEI 1358
               |.:::               :||   ||.|..:....|.:..: ::.|:.....|||...|:
  Fly   323 LPLTGIIV---------------NRL---EDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVEL 369

Human  1359 VHVKS-------------------------------ESEGRPERVFHLCC--SSPESRKDFLKAV 1390
            ::..:                               :|.|...| |.||.  |||..        
  Fly   370 LNANNPSLPMGIKRQLSNLSNSSLGHLNAAHLSQHLDSRGYCTR-FSLCAYYSSPPC-------- 425

Human  1391 HSILRDKHRRQL---LKTESLPSSQQYVPFGG--KRLCALKGARPAMSRAVSAPS-------KSL 1443
                   |.|.|   |...:.|::..|.....  .||....|.|.|:.:.:..|.       |.:
  Fly   426 -------HVRPLRVTLPPSNYPATAPYANLSAHFARLVKGGGLRSAIVKMLLYPQARQSIDLKRI 483

Human  1444 GRRRRRLARNRFTIDSDAVSASSPEKESQQPPGGGDTDRWVEEQFDL-AQYEEQDDIKETDIL-- 1505
            ..|:||..:         .||...:..:.|..|..:.:|  ::..:| ...|..||..|.|.|  
  Fly   484 ALRKRRCHK---------ASAKLKDLNTNQDSGQSELER--QDAIELPTDSESYDDDFEDDFLHS 537

Human  1506 --SD------------DDEFCESVKGASVDRDLQERLQATSISQRERGRKTLDS----HASRMAQ 1552
              ||            :|..|.|. |..||.....|...:||:..:     |||    ....:.:
  Fly   538 CDSDPFEYVQFYQNKRNDSMCNST-GTFVDHGTGARRHCSSINLIK-----LDSADTDEVLALNE 596

Human  1553 LKKQAALSG 1561
            |||::.:.|
  Fly   597 LKKESLVIG 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TIAM1NP_003244.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..379
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 393..422
PH1_Tiam1_2 432..558 CDD:269937
Tiam_CC_Ex 572..669 CDD:408184
Ubl1_cv_Nsp3_N-like 766..832 CDD:475130
PDZ 858..>901 CDD:214570
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..1034 5/24 (21%)
RhoGEF 1044..1233 CDD:214619 51/190 (27%)
PH2_Tiam1_2 1235..1406 CDD:269957 42/244 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1456..1482 4/25 (16%)
RtGEFNP_001097184.2 SH3_PIX 6..58 CDD:212810 3/11 (27%)
RhoGEF 79..249 CDD:238091 58/217 (27%)
PH_Cool_Pix 281..376 CDD:269932 17/112 (15%)
Blue background indicates that the domain is not in the aligned region.

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