Protein Alignment TIAM1 and Pura

DIOPT Version :10

• Sequence 1: NP_003244.2
• Gene: TIAM1 / 7074
• HGNCID: 11805
• Length: 1591
• Species: Homo sapiens
• Sequence 2: NP_996016.2
• Gene: Pura / 2768948
• FlyBaseID: FBgn0035802
• Length: 1904
• Species: Drosophila melanogaster
• Alignment Length: 1585
• Identity: 312/1585 - (19%)
• Similarity: 533/1585 - (33%)
• Gaps: 490/1585 - (30%)

Human   153 TSNGPTFMETASFK--------------KKRSKSAD---------IWR----EDSL--------- 181
            ||||...::.:..:              |..|..:|         :||    |:|:
  Fly   400 TSNGALVLQLSDAEIAHALRPSELYLCIKLESTESDADCKPRLYAVWRSSRKEESVQSHCIDHEN 464

Human   182 --EFSLSDLSQEHLTSNEEILGSAEEKDCEE------------ARGMETRASPRQLSTCQRANSL 232
              |..||.|..|..|:...::.|    ||.|            .|.:| |.|..:|......:..
  Fly   465 PGELPLSVLQLEMSTAAAALMAS----DCGELPQLLQNLLVSVERSIE-RVSLNELQMPMHHDRG 524

Human   233 GD-LYAQKNSGVTAN--GGPGSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKS 294
            .| |....|:|...|  |.|      .|....||:  :..:|:             :|      |
  Fly   525 EDSLDEANNNGCNNNLLGSP------KCALRRSDL--ITKNKL-------------FN------S 562

Human   295 HCLSEGATNPQISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGATTDTDLLSRRSN-----ATN 354
            ..:....||.|.|.:::..|.  ....|.::...|..:.|..|...|.......|||     |:.
  Fly   563 RYMLRRLTNRQDSMNSTSSGN--SNVSDRSSSSSSSSSSSAGEELLTSHSEAKMRSNSVGNEASG 625

Human   355 SSYSPT-----TGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQ-- 412
            :|.||.     .|.:|...||...:: |:...|.:.:      :.|..:|.|..:..|...|:
  Fly   626 ASTSPALPLYCLGNSFPHIDSDEEAS-DSIGPGKHHS------LETCETELLPSSSIAELPEKLL 683

Human   413 SSGTLSSPG----QSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCT 473
            :|| :..||    |.|.|:|.....|..||.            ...|.||...:.........|.
  Fly   684 TSG-VYLPGTRTLQGDPLVTVDAACVASAGI------------NCYEMATLLLYYSTIPERSSCP 735

Human   474 LFFYESDGRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQT----- 533
            .....:.|.:.    :|..|....:....|...:..|:                |...||
  Fly   736 FTTPATPGTTA----TINGHKSTEQQQQQQQQQQQQKQ----------------QPAQQTFTILI 780

Human   534 --ELENWITAIHSACATAVARHHHKEDTLRLLKSEIKKLE-----------QKIDMDEKMKKMGE 585
              |....:..|...|           .:||||..:|...|           |..:..::.|...:
  Fly   781 AIEKSQHLCVIDLIC-----------QSLRLLAKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQ 834

Human   586 MQLSSVTDSKK----------KKTILDQIFV---------------------------------W 607
            .|.::.:|..:          |...:||:..                                 |
  Fly   835 QQQNNNSDHPEPSSPSPVDLVKFISVDQVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHDATKW 899

Human   608 EQ---NLEQFQMD-----------LFRFRCYLASLQGGELPNPKRL------LAFASRPTKV-AM 651
            .:   .||.||..           |...|.  |.|||  ||..::|      |:.|...::: ::
  Fly   900 REFFAQLEAFQRQCSTAGGRLVSALSEIRA--ADLQG--LPTRRQLYGQHRALSRALMDSQLHSL 960

Human   652 GRLGIFSVSSFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPSINQVF 716
            .::|...::....|..|.|...|..|.|.....|:|.....|.:   :|...|.::    :..:|
  Fly   961 RKMGAGQLARLQDLARAITSAPGSPRMTSQPQSSSSSSSGAFLN---VDAACKLRK----VTLLF 1018

Human   717 GEGTEAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTVV 781
            .|...|.:: ||.:.:.     :||:...|........:    :.|  ..||.
  Fly  1019 NEVDRAAQR-LEQLTEQ-----RRERLRQLTRQRALEDE----ISE--VTSWM------------ 1059

Human   782 RPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQPE-EDIYELLYKEIEICPKVTQS 845
              |....:.|:...:.|.              :|:.||...:.| |..|.:..|
  Fly  1060 --GSDGAENLQKFSQLHW--------------DNESQLRTQEQEFEKYYFIAMK----------- 1097

Human   846 IHIEKS-DTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEI------NNRAA 903
             |:.|. |..|.....|:.|...:.::.......::..||.::...|| .:|.:      .|.|.
  Fly  1098 -HLAKGRDLHAAALKVSVLSESANNLKSALDQFAQKLELAHERYDAAG-RLLHLLTQHQRENAAR 1160

Human   904 DALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADLGESPLAFLTSN------- 961
            :.|  ..|.:.|...|  ||.:.:|.:.:...|    |.....||......:::..|:
  Fly  1161 EEL--QRLAEQLGATS--LLEKHWPVMRKTHTL----PVASSTPAAAAGKRVSYRCSSASRSSFE 1217

Human   962 --PGHSLCS--EQGSSAE-----TAPEETEGPDLESSDETDHSSKSTE-------------QVAA 1004
              |..|.||  .:..:.|     ...||.:..|.:..|..:..||..:             ::|.
  Fly  1218 GGPSSSNCSCWRESRNLEDMDQMEEEEEEQDHDCDGGDGEEQQSKIADSGLGVCDNCERNPKLAR 1282

Human  1005 F--CRSLHEMN------------PS----DQSPSPQDS--------TGPQLATMRQLSDAD-KLR 1042
            .  |:||:|.:            ||    |...||.::        :..:|..:.:||..| |::
  Fly  1283 ICSCQSLNEKSHDELLEDECFDRPSKRYMDIMHSPMEANAHLQCHGSSLELPKLEELSCLDPKIQ 1347

Human  1043 K----VICELLETERTYVKDLNCLMERYLKPLQKETF--LTQDELDVLFGNLTEMVEF-QVEFLK 1100
            |    ::.|::.|||.||:.|..::|.|:..|.:|..  ..:.:.:|:|||:.::.|| ...||.
  Fly  1348 KTLLLIMREMIGTERDYVRSLYYVIENYIDELLREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLG 1412

Human  1101 TLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAF 1165
            .||                ::::....:|.:||....:|.||:.:..:         |.|:||..
  Fly  1413 ELE----------------RYERNPLKVGAAFLEMESKFYLYALYNKN---------KPKSDTLL 1452

Human  1166 KAFLDA-QNPKQ---QHSSTLESYLIKPIQRILKYPLLLRELF-ALTDAESEEHYHLDVAIKTMN 1225
            ..:..: ..|||   |....|.|||:||:||:.||.|||::|. |....|.          ..:.
  Fly  1453 SEYGSSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEG----------AALQ 1507

Human  1226 KVASHINEMQKIHE------EFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTT-VIWLNPPASLG 1283
            ::|:.:.|:|:..|      ..|   :.|:|..:....:|.....|.||.... ::|      .|
  Fly  1508 EIAADVEELQRAEEMVKFQLRHG---NDLLAMDSLRDCDVNVKEQGRLLRQNEFLVW------QG 1563

Human  1284 KWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASA 1348
            :..|:.....|:|:..|:.     ||       :.|...:::.|.:.:::.|.|..:   .|.:.
  Fly  1564 RGGKKTLRQVFLFEELVLF-----SK-------ARRFPDHKNLDIYIYKNSIKTSDI---GLTAH 1613

Human  1349 DAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKAVHSILRDKHRR----QLLKTESL- 1408
            ..::....||...|.    :|:..:.|.|.|.:.:..:.:.:..:|..:.:|    :|.:..|:
  Fly  1614 TGDSATKFEIWFRKR----KPDDTWMLQCMSEDIKNAWTEEISKLLWKQAKRNREVRLAEMSSMG 1674

Human  1409 ----------PSSQQY----VPFGGKRLCALKGARPAMSRAVSAPSKSLGRR------RRRLARN 1453
                      ||:.|.    :|.      |.....|.:..  |.|.|...||      ...|:..
  Fly  1675 IGSKPCLDIRPSNNQISDRSIPL------AQLNKTPKLRH--SEPGKGSMRRPNSLISESSLSSG 1731

Human  1454 RFTIDSDAVSASSPEKESQQPPGGG 1478
            ..|....::|..|   .|....|||
  Fly  1732 TSTTSGSSISGGS---SSGHNDGGG 1753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TIAM1	NP_003244.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..379		22/90 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..422		9/34 (26%)
		PH1_Tiam1_2	432..558	CDD:269937	18/132 (14%)
		Tiam_CC_Ex	572..669	CDD:408184	25/160 (16%)
		Ubl1_cv_Nsp3_N-like	766..832	CDD:475130	11/66 (17%)
		PDZ	858..>901	CDD:214570	7/48 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..1034		26/149 (17%)
		RhoGEF	1044..1233	CDD:214619	52/196 (27%)
		PH2_Tiam1_2	1235..1406	CDD:269957	32/181 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1456..1482		7/23 (30%)
Pura	NP_996016.2	COG4913	<1020..>1167	CDD:443941	34/201 (17%)
		RhoGEF	1353..1524	CDD:459876	55/205 (27%)
		PH_puratrophin-1	1524..1663	CDD:270062	29/166 (17%)