Protein Alignment TIAM1 and tiam-1

DIOPT Version :10

• Sequence 1: NP_003244.2
• Gene: TIAM1 / 7074
• HGNCID: 11805
• Length: 1591
• Species: Homo sapiens
• Sequence 2: NP_491367.3
• Gene: tiam-1 / 259373
• WormBaseID: WBGene00015704
• Length: 889
• Species: Caenorhabditis elegans
• Alignment Length: 941
• Identity: 184/941 - (19%)
• Similarity: 350/941 - (37%)
• Gaps: 207/941 - (21%)

Human   508 HPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACATAVARHHHKEDTLRLLKSEIKKLEQ 572
            |...|| |....:.|....|.|.|..:....|:...:..|..:.:|.......|:...|...::
 Worm    83 HKVSDF-FVYLKTEGRTIGFNTLSSRDTSLLISQATNTTAFNMFQHSFSVSVSRIATFEGDSIQ- 145

Human   573 KIDMDEKMKKMGEMQLSSVTDSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPK 637
              ..||      :.:.|:|:.:.     |:.:|    |.:...:::....|:..|.:.....:
 Worm   146 --PCDE------QPETSNVSLNP-----LNMVF----NYKGSPVEIDLLECFACSSEAENCVD-- 191

Human   638 RLLAFASRPTKV---AMGRLGIFSVSSFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGL 699
              :|.|:...:|   |...|.:....:..:|:.|||....|  ....::|...|.:.:..:|  |
 Worm   192 --IAHANNIFRVIVSAHAHLFLIQALNVSSLLLARTTSNLV--AINYLARQNDKIQQKLIAL--L 250

Human   700 DTT-SKKKQGRPSINQVFGEGTEAVKKSLEGIFDDIVPDGKREKEVVLPNV----HQHNPDCDIW 759
            :|: |.:...:..|.|:.......|.:.|..:           ::..||.:    |..:|..|..
 Worm   251 ETSESSENASKEDIRQMLLLKNVVVTQRLNSL-----------QQRALPGIELIQHDISPQIDQK 304

Human   760 VHEYF-TPSWFCLPNNQPALTVVRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQ 823
            :.|.. .||.|....|..:..:.|   ...:|.::......:..::.|.::...|:|:.    |.
 Worm   305 LLEKCRLPSLFLYHFNMNSFRIWR---KPMETRDMNTMGSSMASTSQYHQIPIQIQNQN----PL 362

Human   824 PEEDIYELLYKEIEICPKVTQSIH------IEKSDTAADTY--------------GFSLSSVEED 868
            |.:          :|.|:..|..|      .....|...|.              |.||:...|.
 Worm   363 PSQ----------QIQPQQQQQYHPPDHVTTHNGTTTFHTTNPTKPRLCEGSLAPGCSLAEASEQ 417

Human   869 GIRRLYVNSVKETGLASKKGLKAGDEILEINNRAADALNSSMLKDFLSQPSLGLLVRT-YPELEE 932
                      ::..:|.:|...||               .|..:|:..:.:.|.|..| |...::
 Worm   418 ----------RKREMAEQKKELAG---------------PSSAEDYFVRKTNGRLGLTIYAHNDD 457

Human   933 GVELLESPPHRVDGPADLGESPLAFLTSNPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSK 997
            ||...|     |.|.......             |::.|.|......|.......:||
 Worm   458 GVIRAE-----VRGVTSFAPR-------------CAQVGDSVVAVDSELISSVRNASD------- 497

Human   998 STEQVAAFCRSLH--EMNP-SDQSPSPQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDL 1059
             .|::....:.:|  ...| :.::||..|:|     .:.:.:...||...:.|||.||:.||.||
 Worm   498 -VEKLLRIGKVIHLRRKTPLTPRAPSQLDAT-----NVNKKTGCAKLAMALQELLVTEKKYVSDL 556

Human  1060 NCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLE-KVDQFKK 1123
            ..:         .|.||...::..:......:.:.|..|:.::|:.   :.|:.:.: .|.|.:.
 Worm   557 REM---------NEVFLCMRQVRDIMNAAIRLYKMQTSFVDSIEEA---IGDMSRQDISVAQIRD 609

Human  1124 VLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIK 1188
            .:..:...|:.....||:|:.:.|.:..:... :|.|.:...|  |:|.|..::...:.||.:||
 Worm   610 SVMRVCAVFINKCSDFKIYAEYAAGYHLLQHE-IKNKKELLSK--LEAVNSTREQHCSWESRMIK 671

Human  1189 PIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVF-------D 1246
            |:|||::|||||:.:......::.|...::.|::.|...|.::||||::||::....       :
 Worm   672 PVQRIVQYPLLLKNIADALPKDARERVQVEAALQKMQTSAEYVNEMQRLHEDYAQYMETVRKANE 736

Human  1247 QLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQK 1311
            .::||::      ..|...:||:...:.|.:.||.        ....|||.:.::|:.....|:.
 Worm   737 PMLAEKS------LRLDTRELLVFAHIKWRDAPAE--------HYVVFVFHSLILLLPSYARKEI 787

Human  1312 K----KLVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERV 1372
            |    :::..:.:.|.|          :|.:||.::...:|....|.        ..|...|..|
 Worm   788 KMKWTRVLPINEVDINE----------MPNDALNLKLYHAAFEGPNG--------QLSHSNPNTV 834

Human  1373 FHL-CCSSPESR---KDFLKAVHSILRDKHR 1399
            ::: ||.|...:   |:..||.....|:.||
 Worm   835 YNIECCQSQLKQHLIKNIKKARTLFSRESHR 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TIAM1	NP_003244.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..379
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..422
		PH1_Tiam1_2	432..558	CDD:269937	11/49 (22%)
		Tiam_CC_Ex	572..669	CDD:408184	15/99 (15%)
		Ubl1_cv_Nsp3_N-like	766..832	CDD:475130	11/65 (17%)
		PDZ	858..>901	CDD:214570	8/56 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..1034		15/97 (15%)
		RhoGEF	1044..1233	CDD:214619	46/189 (24%)
		PH2_Tiam1_2	1235..1406	CDD:269957	36/180 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1456..1482
tiam-1	NP_491367.3	PDZ_canonical	440..511	CDD:483948	17/96 (18%)
		RhoGEF	541..715	CDD:238091	46/188 (24%)