DRSC/TRiP Functional Genomics Resources

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Protein Alignment TIAM1 and scd1

DIOPT Version :10

Sequence 1:NP_003244.2 Gene:TIAM1 / 7074 HGNCID:11805 Length:1591 Species:Homo sapiens
Sequence 2:NP_594221.1 Gene:scd1 / 2542337 PomBaseID:SPAC16E8.09 Length:872 Species:Schizosaccharomyces pombe


Alignment Length:601 Identity:147/601 - (24%)
Similarity:251/601 - (41%) Gaps:117/601 - (19%)


- Green bases have known domain annotations that are detailed below.


Human  1015 SDQSPSPQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQD 1079
            |..:|||.........|:..|..:.  |:|..||.|||..|::||..| ..|:..||::..|:||
pombe   205 SSSTPSPSTDDNVPTGTLNSLIASG--RRVTAELYETELKYIQDLEYL-SNYMVILQQKQILSQD 266

Human  1080 ELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSA 1144
            .:..:|.||.|:::||..||..||..:.|..:.::             ||..|:...:.|.:|..
pombe   267 TILSIFTNLNEILDFQRRFLVGLEMNLSLPVEEQR-------------LGALFIALEEGFSVYQV 318

Human  1145 FCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLE-SY-----LIKPIQRILKYPLLLREL 1203
            ||.:.....::::            |.||...:.::.|| ||     ||||||||.||||||.:|
pombe   319 FCTNFPNAQQLII------------DNQNQLLKVANLLEPSYELPALLIKPIQRICKYPLLLNQL 371

Human  1204 FALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAV--FDQLIAEQTGEKKEVADLSMGD 1266
            ...|.:..:....|...:..:.:||:.:||.::|||...|:  .:|.:.:..|...:.    .|.
pombe   372 LKGTPSGYQYEEELKQGMACVVRVANQVNETRRIHENRNAIIELEQRVIDWKGYSLQY----FGQ 432

Human  1267 LLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIYEDWDPFRF 1331
            ||:...|       ::.|...|.|...::|: .::|..|:.|..|::   :..:|:.:.      
pombe   433 LLVWDVV-------NVCKADIEREYHVYLFE-KILLCCKEMSTLKRQ---ARSISMNKK------ 480

Human  1332 RHMIPTEALQVRALASADAEANAVCEIVHVKSES-----EGRPE-RVFHLCCSSPESRKDFLKAV 1390
            ...:.:..|:.|.|.|   ....|....|:.|.:     .|.|: ..|.|...:.||.|.::..:
pombe   481 TKRLDSLQLKGRILTS---NITTVVPNHHMGSYAIQIFWRGDPQHESFILKLRNEESHKLWMSVL 542

Human  1391 HSIL-RDKH--RRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGRRRRRLAR 1452
            :.:| :::|  .:.:....|.|                  |.|..:|:.|..||........|.|
pombe   543 NRLLWKNEHGSPKDIRSAASTP------------------ANPVYNRSSSQTSKGYNSSDYDLLR 589

Human  1453 NRFTIDSDA---VSASSPEKESQQPPGGGDTDRWVEEQFDLAQYEEQDDIKETDILSDDDEFCES 1514
            .. ::|.:.   .|.|||..:|.  |....|.:      |.......|: :.:|.:..:.|  ||
pombe   590 TH-SLDENVNSPTSISSPSSKSS--PFTKTTSK------DTKSATTTDE-RPSDFIRLNSE--ES 642

Human  1515 VKGASVDRDLQERLQATSISQRERGRKTLDSHASRMAQL---------KKQAALSGINGGLESAS 1570
            | |.|..|..|  ..:|.:|.......::.|..||::|:         .:|:.::.:..|.:..|
pombe   643 V-GTSSLRTSQ--TTSTIVSNDSSSTASIPSQISRISQVNSLLNDYNYNRQSHITRVYSGTDDGS 704

Human  1571 EEVIWVRREDFAPSRK 1586
            ...|:   ||.:.|.|
pombe   705 SVSIF---EDTSSSTK 717

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TIAM1NP_003244.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..379
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 393..422
PH1_Tiam1_2 432..558 CDD:269937
Tiam_CC_Ex 572..669 CDD:408184
Ubl1_cv_Nsp3_N-like 766..832 CDD:475130
PDZ 858..>901 CDD:214570
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..1034 5/18 (28%)
RhoGEF 1044..1233 CDD:214619 60/194 (31%)
PH2_Tiam1_2 1235..1406 CDD:269957 35/181 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1456..1482 8/28 (29%)
scd1NP_594221.1 CDC24 105..194 CDD:399412
RhoGEF 230..400 CDD:238091 61/195 (31%)
PH_Scd1 404..546 CDD:270066 33/165 (20%)
PB1 775..870 CDD:395447
Blue background indicates that the domain is not in the aligned region.

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