DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TIAM1 and tiam1b

DIOPT Version :10

Sequence 1:NP_003244.2 Gene:TIAM1 / 7074 HGNCID:11805 Length:1591 Species:Homo sapiens
Sequence 2:XP_009290217.1 Gene:tiam1b / 100330358 ZFINID:ZDB-GENE-120221-1 Length:1562 Species:Danio rerio


Alignment Length:1638 Identity:1014/1638 - (61%)
Similarity:1192/1638 - (72%) Gaps:142/1638 - (8%)


- Green bases have known domain annotations that are detailed below.


Human     1 MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHK-TRRTRHASSGKVIHRNSEVSTRSSSTPSI 64
            ||||||....|.:||:....|.|||.|||||||.| |..||...|||..|||||.||||||||||
Zfish     1 MGNAESHSGGHGYYGDGQRQLSRKHMSRSLRLSSKQTYCTRRTPSGKPEHRNSETSTRSSSTPSI 65

Human    65 PQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTDSSV-TPSVDSSIVLTAASVQSMPD 128
            |||||::|||||:....|.||.||||||||.|.|||:|:.:... :|:|             .|.
Zfish    66 PQSLADHGLEPFNDSDLLPDFSSPIWVDRVAMNLRPMSFHNQPPHSPAV-------------KPP 117

Human   129 TEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETA--SFKKKRSKSADIWREDSLEFSLSDLSQE 191
            .|.:::              ||   :..||..:.:  .||||||||||:|||||||.||||||||
Zfish   118 EENAQV--------------QH---TRSPTTRDASQDGFKKKRSKSADMWREDSLEVSLSDLSQE 165

Human   192 HLTSNEEILGSAEEKDCEEARGMETRASPRQLSTCQRANSLGDLYAQKNS-GVTA---NGGPGSK 252
            |:||.||:   |:..|...|:              .|||||.:||..|.| |..|   .||.|.:
Zfish   166 HMTSTEEM---ADTPDTHSAQ--------------DRANSLDELYGTKPSHGRYARWHKGGAGDE 213

Human   253 FAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEGATNPQISHSNSMQGRRA 317
                             .||..:..|:........|||||:|||||||.||.|    ..||||||
Zfish   214 -----------------EKMMMSPCEDDGAAYGAFTLPCRRSHCLSEGPTNQQ----GVMQGRRA 257

Human   318 KTTQDVNAGEGSEFADSGIEGAT-TDTDLLSRRS------NATNSSYSPTTGRAFVGSDSGSSST 375
            :|.|||.|.:||::.||||:|.| .|::|...:|      :.:.|:||...|.||.|||||||| 
Zfish   258 QTIQDVTAADGSDYEDSGIDGVTVADSELSQHQSRRYKTMSVSFSAYSTPAGGAFTGSDSGSSS- 321

Human   376 GDAA-----RQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSP--GQSDILL--TAAQ 431
            |.||     .||||||||:|||.|...:|:.|:...|.||||||.||||.  ..:|.||  :|.|
Zfish   322 GAAATNTDNTQGVYENFRQELEQSVCPAEAPEDRSCAFSDEQSSVTLSSAYHTHTDPLLSVSAVQ 386

Human   432 GTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVW 496
            |||||||.||||||||||||||||.|.|||||.||||||||||||||:||||||||||:||||||
Zfish   387 GTVRKAGRLAVKNFLVHKKNKKVELAPRRKWKSYWVSLKGCTLFFYETDGRSGIDHNSVPKHAVW 451

Human   497 VENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACATAVARHHHKEDTLR 561
            .||||||||||||||||||||||||||:|||||.||||||||||.||||||.||||.||:|||:|
Zfish   452 AENSIVQAVPEHPKKDFVFCLSNSLGDSFLFQTCSQTELENWITGIHSACAAAVARQHHREDTVR 516

Human   562 LLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLA 626
            ||::||:||||||||||||||||:||||:|||:||:||||:|||:||||||||.||||||||||:
Zfish   517 LLRAEIRKLEQKIDMDEKMKKMGDMQLSAVTDAKKRKTILEQIFLWEQNLEQFHMDLFRFRCYLS 581

Human   627 SLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVSSFHALVAARTGETGVRRRTQAMSRSASKRRS 691
            ||||||||||||||||||||||:||||||||||||||||||||| |:||||||||||||.|||:|
Zfish   582 SLQGGELPNPKRLLAFASRPTKLAMGRLGIFSVSSFHALVAART-ESGVRRRTQAMSRSTSKRKS 645

Human   692 RFSSLWGLDTTSKKK-QGRPSINQVFGEGTEAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPD 755
            ||||||||||.||:| :|.|||:|||.||.:.||..|||:|:....:..::.:..:..:.:.|.|
Zfish   646 RFSSLWGLDTHSKRKSKGHPSIDQVFAEGDDPVKSPLEGMFEGSSSETMKDTKTPVKGLPRPNTD 710

Human   756 CDIWVHEYFTPSWFCLPNNQPALTVVRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLY 820
            .|||..::.||||..|||:||.|.:::||::|.|.||.|||.||||.:.||:||||||||::|.|
Zfish   711 HDIWSRDHLTPSWVLLPNDQPVLAIIQPGESALDMLETICKAHQLDATKHYVRLKFLIENQVQFY 775

Human   821 VPQPEEDIYELLYKEIEICPKVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLAS 885
            :|:||||||:|||||||:|.|:.:.|..::.::....||||:|.|||||:::||:..|:..|||.
Zfish   776 IPKPEEDIYDLLYKEIELCCKIRKVIQFDRDESCMIGYGFSISVVEEDGVQQLYITDVRAGGLAF 840

Human   886 KKGLKAGDEILEINNRAADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADL 950
            .|||.||||||::|.:.:..|..:.:|...:|.||.|.|.|.|.:|.. :|...||.|.|...:|
Zfish   841 AKGLNAGDEILQLNGKDSRTLTFADMKVAFAQVSLSLTVNTLPPVERR-QLCYLPPRRSDAVDNL 904

Human   951 -----GESPLAFLTSNPGHSLCSEQGSSAETAPEETEGPDLESSDET----DHSSKSTEQVAAFC 1006
                 .:|....|....|..:             ||.|..|:...|.    |...||||||||||
Zfish   905 YTDIFSQSQEEILDDGVGLIV-------------ETSGDSLDDDSELFAEFDDYGKSTEQVAAFC 956

Human  1007 RSLHEMNPS-----DQSPSPQDST-GPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMER 1065
            |||||||||     ..|..|:.|: .|..||.||||||||||||||||:|||||||||||||:.|
Zfish   957 RSLHEMNPSSSESVSSSSVPESSSLPPSTATPRQLSDADKLRKVICELVETERTYVKDLNCLIGR 1021

Human  1066 YLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGG 1130
            ||.|||||:||||||||||||||.||:|||||||||||||.||||||||||:|::|||:||||||
Zfish  1022 YLTPLQKESFLTQDELDVLFGNLPEMLEFQVEFLKTLEDGTRLVPDLEKLERVEEFKKILFSLGG 1086

Human  1131 SFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILK 1195
            ||||||||||:|||||||||||||||||||||.|||||||.:||||||||||||||||||||:||
Zfish  1087 SFLYYADRFKIYSAFCASHTKVPKVLVKAKTDAAFKAFLDERNPKQQHSSTLESYLIKPIQRVLK 1151

Human  1196 YPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVA 1260
            ||||||||.:|||.:|||||||:||:|.||.||||||||||||||||||||.||:||||||||||
Zfish  1152 YPLLLRELHSLTDPDSEEHYHLNVAMKAMNTVASHINEMQKIHEEFGAVFDLLISEQTGEKKEVA 1216

Human  1261 DLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIY-E 1324
            ||||||||||::|.|:||.:||||.||||:||.||||||||.|.||.||||||:.||||.|:. |
Zfish  1217 DLSMGDLLLHSSVTWINPSSSLGKCKKEPQLATFVFKTAVVFVCKDYSKQKKKMGGSHRASVSGE 1281

Human  1325 DWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKA 1389
            :.|||||||||||:|||||.|::.|.|:.|||||||:||||||||||||.||||||||:|||||.
Zfish  1282 EKDPFRFRHMIPTDALQVRTLSNTDGESAAVCEIVHIKSESEGRPERVFQLCCSSPESKKDFLKT 1346

Human  1390 VHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGRRRRRLARNR 1454
            ||||||||.|||||||||||.||||||||||||||||||||||:|||||||::||  ||:|.|||
Zfish  1347 VHSILRDKQRRQLLKTESLPLSQQYVPFGGKRLCALKGARPAMNRAVSAPSRTLG--RRKLVRNR 1409

Human  1455 FTIDSDAVSASSPEKES------QQPPG--GGDTDRWVEEQFDLAQYEEQD-DIKETDILSDDDE 1510
            ||||:|.|..:.|:.:|      ||..|  .|||||||||||||.:||||: |:|||||||||::
Zfish  1410 FTIDTDIVFDTEPDSDSPDSQHAQQTIGVPAGDTDRWVEEQFDLQRYEEQEQDVKETDILSDDED 1474

Human  1511 FCESVKGASVDRDLQ------ERLQATSISQRERGRKTLDSHASRMAQLKKQAALSGINGGLESA 1569
            ||.|....|.:..|.      :..:....::.|..||...|..::::.:.||.|:|..:...::.
Zfish  1475 FCPSAMSPSTEPLLSTLSLEGDTAEEEEEAEEEDSRKDCKSQHAKLSDVGKQCAMSVASVDEQAT 1539

Human  1570 SEEVIWVRREDFA 1582
            |::|:||||:..|
Zfish  1540 SDDVVWVRRDSGA 1552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TIAM1NP_003244.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78 52/77 (68%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..379 43/87 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 393..422 14/30 (47%)
PH1_Tiam1_2 432..558 CDD:269937 112/125 (90%)
Tiam_CC_Ex 572..669 CDD:408184 87/96 (91%)
Ubl1_cv_Nsp3_N-like 766..832 CDD:475130 41/65 (63%)
PDZ 858..>901 CDD:214570 26/42 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..1034 39/109 (36%)
RhoGEF 1044..1233 CDD:214619 163/188 (87%)
PH2_Tiam1_2 1235..1406 CDD:269957 136/171 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1456..1482 13/33 (39%)
tiam1bXP_009290217.1 PH1_Tiam1_2 387..513 CDD:269937 112/125 (90%)
Tiam_CC_Ex 527..624 CDD:408184 87/96 (91%)
RBD 721..794 CDD:460485 48/72 (67%)
PDZ 797..884 CDD:214570 35/86 (41%)
RhoGEF 1000..1189 CDD:214619 163/188 (87%)
PH2_Tiam1_2 1191..1363 CDD:269957 136/171 (80%)

Return to query results.
Submit another query.