DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TIAL1 and PUB1

DIOPT Version :9

Sequence 1:	NP_001029097.1	Gene:	TIAL1 / 7073	HGNCID:	11804	Length:	392	Species:	Homo sapiens
Sequence 2:	NP_014382.1	Gene:	PUB1 / 855716	SGDID:	S000004961	Length:	453	Species:	Saccharomyces cerevisiae

Alignment Length:	385	Identity:	110/385 - (28%)
Similarity:	172/385 - (44%)	Gaps:	95/385 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     9 RTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYCFVEFY 73
            |.||||||.:.:||.::.|.|...||..:.|::.:: :::.||               |.|||::
Yeast    75 RVLYVGNLDKAITEDILKQYFQVGGPIANIKIMIDK-NNKNVN---------------YAFVEYH 123

Human    74 EHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFG 138
            :..||..||..:||::|....||:|||.  .||:..:.:.|::|||||:..:..|.:::||..|.
Yeast   124 QSHDANIALQTLNGKQIENNIVKINWAF--QSQQSSSDDTFNLFVGDLNVNVDDETLRNAFKDFP 186

Human   139 KISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRK---------- 193
            ......|:.||.||.|:|||||||.::.||:||:..|.||.|.||.:|.|||.::
Yeast   187 SYLSGHVMWDMQTGSSRGYGFVSFTSQDDAQNAMDSMQGQDLNGRPLRINWAAKRDNNNNNNYQQ 251

Human   194 -----------------------------------------PPA-----------PKSTQENNTK 206
                                                     ||:           |...|...::
Yeast   252 RRNYGNNNRGGFRQYNSNNNNNMNMGMNMNMNMNMNNSRGMPPSSMGMPIGAMPLPSQGQPQQSQ 316

Human   207 QL---------RFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFV 262
            .:         ..:.::..:.|:..|.|.|.|....|:..:...|..||.|::.:.:||||..|:
Yeast   317 TIGLPPQVNPQAVDHIIRSAPPRVTTAYIGNIPHFATEADLIPLFQNFGFILDFKHYPEKGCCFI 381

Human   263 RFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQ 322
            ::.|||.||..||::.....:|..::..||||    ..||......|.||  .:..|.||
Yeast   382 KYDTHEQAAVCIVALANFPFQGRNLRTGWGKE----RSNFMPQQQQQGGQ--PLIMNDQQ 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TIAL1	NP_001029097.1	RRM1_TIAR	10..107	CDD:410028	32/96 (33%)
		RRM2_TIAR	113..192	CDD:410029	37/78 (47%)
		RRM3_TIAR	222..294	CDD:241064	24/71 (34%)
PUB1	NP_014382.1	RRM1_PUB1	77..150	CDD:410026	29/88 (33%)
		RRM2_PUB1	161..240	CDD:410031	37/78 (47%)
		RRM3_PUB1	341..414	CDD:410033	26/76 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I2664
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000924
OrthoInspector	1	1.000	-	-		otm52813
orthoMCL	1	0.900	-	-		OOG6_103013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1842
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.800