Protein Alignment TIAL1 and Rox8

DIOPT Version :10

• Sequence 1: NP_001029097.1
• Gene: TIAL1 / 7073
• HGNCID: 11804
• Length: 392
• Species: Homo sapiens
• Sequence 2: NP_732944.2
• Gene: Rox8 / 42848
• FlyBaseID: FBgn0005649
• Length: 470
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 185/494 - (37%)
• Similarity: 238/494 - (48%)
• Gaps: 130/494 - (26%)

Human     4 DDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYC 68
            |:.||:|||||||...|:|.|::.|||.:||.||||:|.|                  ..||||.
  Fly     2 DESQPKTLYVGNLDSSVSEDLLIALFSTMGPVKSCKIIRE------------------PGNDPYA 48

Human    69 FVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQ-KKDTSNHFHVFVGDLSPEITTEDIKS 132
            |:|:..::.|..||.|||.|..|.||:||||||:|.:| |.|.|:|.|:|||||||||.||.::.
  Fly    49 FIEYSNYQAATTALTAMNKRLFLEKEIKVNWATSPGNQPKTDISSHHHIFVGDLSPEIETETLRE 113

Human   133 AFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAP 197
            ||||||:||:.|:|:|..|.|||||.||||..|.:|||||..|.|||:|.|.|||||:|||.|.|
  Fly   114 AFAPFGEISNCRIVRDPHTMKSKGYAFVSFVKKAEAENAIQAMNGQWIGSRSIRTNWSTRKLPPP 178

Human   198 KSTQE------------------NNTKQLRFEDVVNQSSPKNCTVYCGGIASG-LTDQLMRQTFS 243
            :...:                  ..:::..||:|.|||||.|.||||||.... ::|.||.:.|.
  Fly   179 REPSKGGGQGGGMGGGPGNGSGVKGSQRHTFEEVYNQSSPTNTTVYCGGFPPNVISDDLMHKHFV 243

Human   244 PFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKES------------- 295
            .||.|.::|||.:||:||::|.|.|:|||||...:.:.:.|::|||:||||:
  Fly   244 QFGPIQDVRVFKDKGFSFIKFVTKEAAAHAIEHTHNSEVHGNLVKCFWGKENGGDNSANNLNAAA 308

Human   296 -------------------------PDMTKNFQQV------------------------DYSQWG 311
                                     |......||:                        .|.|.|
  Fly   309 AAAAASANVAAVAAANAAVAAGAGMPGQMMTQQQIAAATGAAIPGQMMTPQQIAAQYPYAYQQMG 373

Human   312 QW--SQVYGNPQQYGQYMANGWQVPPYGVYGQPWN-QQGFGVDQSPSAAWMGGFGAQPPQ--GQA 371
            .|  ...|...|...|||..|     |..|..|.: ||..||.....:|  .|:...||.  ...
  Fly   374 YWYPPATYPTTQMQTQYMQQG-----YYPYAYPTSAQQAGGVPCIQFSA--AGYRMVPPNVAWGV 431

Human   372 PPPVIP------------------PPNQAGYGMASYQTQ 392
            |..|:|                  |.......|..||||
  Fly   432 PGTVVPGVTAAAASAAAAANGSLAPQMMYSAAMPQYQTQ 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TIAL1	NP_001029097.1	RRM1_TIAR	10..107	CDD:410028	45/97 (46%)
		RRM2_TIAR	113..192	CDD:410029	51/78 (65%)
		RRM3_TIAR	222..294	CDD:241064	34/72 (47%)
Rox8	NP_732944.2	RRM1_TIA1_like	9..80	CDD:409788	39/88 (44%)
		RRM2_TIA1_like	96..170	CDD:409789	48/73 (66%)
		RRM_SF	221..292	CDD:473069	32/70 (46%)